Search results for "RBP4"

showing 4 items of 4 documents

Maternal Inheritance of a Recessive RBP4 Defect in Canine Congenital Eye Disease

2018

SUMMARY Maternally skewed transmission of traits has been associated with genomic imprinting and oocyte-derived mRNA. We report canine congenital eye malformations, caused by an amino acid deletion (K12del) near the N terminus of retinol-binding protein (RBP4). The disease is only expressed when both dam and offspring are deletion homozygotes. RBP carries vitamin A (retinol) from hepatic stores to peripheral tissues, including the placenta and developing eye, where it is required to synthesize retinoic acid. Gestational vitamin A deficiency is a known risk factor for ocular birth defects. The K12del mutation disrupts RBP folding in vivo, decreasing its secretion from hepatocytes to serum. T…

0301 basic medicineMaleNon-Mendelian inheritanceProtein Foldingcongenital eye defectEye Diseasesgenetic structuresNATIVE DISULFIDE BONDSMedical PhysiologyRetinoic acidReproductive health and childbirth413 Veterinary scienceMicrophthalmiavitamin Achemistry.chemical_compoundPlasmaA-vitamiini2.1 Biological and endogenous factorsMicrophthalmosPrealbuminCRYSTAL-STRUCTUREAetiologyBase Pairinglcsh:QH301-705.5Sequence DeletionPediatricwhole genome sequencingVITAMIN-A-DEFICIENCYANOPHTHALMIAPenetrancePedigreemedicine.anatomical_structurePhenotypeFemalemedicine.medical_specialtyGenotypeENDOPLASMIC-RETICULUMGenes RecessiveMETABOLISMBiologyGeneral Biochemistry Genetics and Molecular BiologyArticle03 medical and health sciencesDogscanine geneticsInternal medicinePlacentaRETINOL-BINDING-PROTEINGeneticsmedicineAnimalsHumansRecessiveMALFORMATIONSBIOCHEMICAL BASISAmino Acid SequenceAlleleEye Disease and Disorders of VisionNutritiongenome-wide association study030102 biochemistry & molecular biologywestern blottingMUTATIONSta1184RBP4maternal inheritancemedicine.diseaseRetinol-Binding ProteinsRetinol binding proteinnuclear magnetic resonance030104 developmental biologyEndocrinologychemistryGeneslcsh:Biology (General)microphthalmiaGenetic LociHela Cells1182 Biochemistry cell and molecular biologyCongenital Structural Anomalies3111 BiomedicineBiochemistry and Cell BiologyDigestive DiseasesGenomic imprintingRetinol-Binding Proteins PlasmaHeLa Cells
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Levels of serum retinol-binding protein 4 before and after non-surgical periodontal treatment in lean and obese subjects: An interventional study

2018

AimWe aimed to evaluate serum RBP4 levels before and after periodontal therapy in lean and obese subjects with chronic periodontitis (CP) in order to determine its possible association with periodontitis. Materials and MethodsThis is an interventional study for which a total of 112 lean and 119 obese subjects were recruited. Patients with CP were evaluated before and after three months of non-surgical periodontal treatment. Periodontal, anthropometric, biochemical parameters and serum levels of TNF-, IL-6, hs-CRP and RBP4 were assessed. ResultsSerum RBP4 levels were associated with an increased probability of periodontitis (OR=1.60; 95% CI: 1.02-2.50), showing patients with CP to have highe…

AdultMalenon-surgical periodontal treatment0301 basic medicineobesityPeriodontal treatmentmedicine.medical_specialtySerum retinolGastroenterologyBody Mass IndexYoung Adult03 medical and health sciences0302 clinical medicineThinnessInternal medicinemedicineHumansObesityperiodontitisPeriodontitisAnalysis of Variancebusiness.industryRBP4030206 dentistryMiddle AgedAnthropometrymedicine.diseaseChronic periodontitisObesity030104 developmental biologyChronic PeriodontitisPeriodonticsFemaleObese subjectsPeriodontal IndexbusinessRetinol-Binding Proteins Plasmaperiodontal diseasesJournal of Clinical Periodontology
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The new murine hepatic 3A cell line responds to stress stimuli by activating an efficient Unfolded Protein Response (UPR)

2012

In the present study we have investigated the properties of a novel cell line (3A cells) obtained from the liver of 14.5. days post coitum (dpc) wild-type mouse embryo. 3A cells morphology was characterized by fluorescent localization of F-actin and β-catenin. The expression of specific genes and proteins essential to liver function in these cells was comparable or even more efficient then in the differentiated hepatocytic cell line MMH-D6. 3A cells also showed the capability to excrete molecules in extracellular spaces resembling functional bile canaliculi, glycogen storage activity and the ability to control retinol-binding protein 4 secretion in response to retinol deprivation. Their re…

Hepatocytes; ER stress; RBP4BiologyToxicologyCellular modelCell LineMicechemistry.chemical_compoundStress PhysiologicalExtracellularAnimalsHepatocyteSecretionActinbeta CateninAnimalReverse Transcriptase Polymerase Chain ReactionRBP4Gene Expression ProfilingTunicamycinDays post coitumCellular model; ER stress; Hepatocytes; RBP4; Actins; Animals; Cell Line; Fluorescein; Gene Expression Profiling; Glycogen; Liver; Retinol-Binding Proteins Plasma; Reverse Transcriptase Polymerase Chain Reaction; Stress Physiological; Tunicamycin; Unfolded Protein Response; beta Catenin; Mice; ToxicologyGeneral MedicineTunicamycinMolecular biologyActinsLiverchemistryCell cultureUnfolded Protein ResponseUnfolded protein responseER streFluoresceinLiver functionCellular modelRetinol-Binding Proteins PlasmaGlycogenToxicology in Vitro
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Reply

2008

RBP4 STEATOSIS HCV
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