Search results for "RBV"
showing 10 items of 14 documents
Ombitasvir, paritaprevir, and ritonavir, with or without dasabuvir, plus ribavirin for patients with hepatitis C virus genotype 1 or 4 infection with…
2017
Summary Background We ran a compassionate use nationwide programme (ABACUS) to provide access to ombitasvir, paritaprevir, and ritonavir, with dasabuvir, plus ribavirin for hepatitis C virus (HCV) genotype 1 infection and ombitasvir, paritaprevir, and ritonavir, plus ribavirin for HCV genotype 4 infection in patients with cirrhosis at high risk of decompensation while approval of these regimens was pending in Italy. Methods In this prospective observational study, we collected data from a compassionate use nationwide programme from March 17, 2014, to May 28, 2015. Patients with HCV genotype 1 infection and cirrhosis at high risk of decompensation were given coformulated ombitasvir (25 mg), …
Windows darbvirsmas lietotņu automatizācijas rīki
2021
Automatizētā programmatūras testēšana pēdējo 10 gadu laikā ir piedzīvojusi ļoti strauju attīstību, izplatību un izpelnijusies plašu atzinību. Tagad gandrīz katra kompānija, kas izstrādā lietotnes, automatizē vismaz daļu no saviem pastāvīgi atkārtojamajiem testiem. Līdz ar to ir strauji pieaugusi arī pieejamo automatizētās testēšanas rīku izvēle. Kā rezultātā, rodas jautājums: kurš no visiem šobrīd pieejamajiem rīkiem tirgū ir visatbilstošākais konkrētā lietotāja vai kompānijas vajadzībām. Autors savā bakalaura darbā apraksta un praktiski pielieto vairāk kā 10 gan maksas, gan bezmaksas automatizētās testēšanas rīkus un izvērtē tos pēc vairāk kā 20 dažādiem kritērijiem, kas palīdz daudz objek…
Risk of disease decompensation and HCC in patients with HCV cirrhosis non responders to PEG IFN plus RBV
2012
The determinants affecting the internationalisation of the Italian SMEs producing sparkling wines: An empirical study on the RBV of the firms
2014
In the last few years, wine industry has been characterised by profound changes that have determined an intensification of competition on a global scale. The aim of this study is to identify the firms’ internal factors that most influence the export intensity and the ability to fit into the international market of the Italian wineries producing sparkling wines through a resource-based view (RBV) approach. Results of our study supporting the findings of previous empirical researches presented in this paper. In particular, the main factors affecting export intensity are: innovation degree and intensity of investment in advertising and promotion, among firms’ characteristics, and abroad experi…
Learning, knowledge and dynamic capabilities: theoretical implications for competitiveness and innovation in the 21st century
2013
The aim of this paper is to support dynamic capabilities as a strategic tool for company management. We will begin by illustrating the evolution that can be discerned in the process of developing competitive advantage as a result of the organisation s internal analysis. In a first stage, interest was centred on understanding the nature of the firm s assets, and knowing which conditions would make it possible to turn them into lasting and sustainable sources of competitive advantage. During a second phase, interest was shifted towards the dynamic processes of generation, development and accumulation of assets. In this sense, dynamic capabilities are those which allow managers to activate and…
Changing aetiological factors of hepatocellular carcinoma and their potential impact on the effectiveness of surveillance
2011
BACKGROUND: The aetiological factors of hepatocellular carcinoma may vary over time. AIMS: The study assessed the potential impact of the aetiological factors on the effectiveness of surveillance in real-world patients. METHODS: Multicentre, cross-sectional study enrolling consecutive hepatocellular carcinoma cases during a six month period. RESULTS: 1733 cases (1311 prevalent and 422 incident) were recruited (mean age 68.6 years; 46.1% cases over 70 years; 73.9% males; 95.3% with cirrhosis); 63.0% were hepatitis C virus positive and 23.7% were virus negative. Amongst incident HCCs, 34.5% were single ≤3cm and 54.4% met the Milan criteria; 61.6% were diagnosed during surveillance; virus nega…
Cost effectiveness of boceprevir or telaprevir for previously treated patients with genotype 1 chronic hepatitis C.
2013
Background & Aims Randomised controlled trials (RCTs) show that triple therapy (TT) with peginterferon alfa, ribavirin, and boceprevir (BOC) or telaprevir (TVR) is more effective than peginterferon-ribavirin dual therapy (DT) in the treatment of genotype 1 (G1) chronic hepatitis C (CHC) patients with previous relapse (RR), partial response (PAR), and null-response (NR). We assess the cost-effectiveness of TT compared to no therapy in the treatment of patients previously treated with G1 CHC. Methods The available published literature provided the data source. The target population was made up of previously treated Caucasian patients with G1 CHC and these were evaluated over a lifetime horizo…
SUCCESSFUL ORGANISATIONAL MODELS IN THE GREEK WINE INDUSTRY
2018
The objective of this paper is dual. The first is to identify the key factors that characterize the most successful organizational models of firms operating in the Greek wine industry. The second is to verify if the adoption of third party certifications influences the firms performance. In particular, paying attention on the internal resources of firms, the Resource based view approach is proposed as theoretical framework. Through a cluster analysis has been possible gather the wineries observed on the basis of a similar organisational model, while a non parametric test has been used in order to verify the influence of voluntary certifications on firm performance. Findings show that the mo…
PEG-INTERFERON PLUS RIBAVIRIN IN COMPENSATED HCV CIRRHOSIS WITH PORTAL HYPERTENSION: THE ROLE OF RAPID AND EARLY VIROLOGICAL RESPONSE IN PREDICTING T…
2009
Sustainable European fishery and the Friend of the Sea scheme: tools to achieve sustainable development in the fishery sector
2015
This paper investigates the role of the Friend of the Sea (FOS) scheme as a market tool for sustainable competitive advantage. To capture this effect, we apply a theoretical framework based on the stakeholder theory (SHT) and the natural-resource-based view (NRBV) to two case studies each in Italy and Spain. Our model allows us to explain the main factors determining an effective and competitive sustainable business model in the fishery sector. The results confirm the relevant influence of market forces in acquiring FOS certification and the role of the same as a counterpart to state authority.