Search results for "RCA"
showing 10 items of 3171 documents
What are the Cancer Risks in BRCA Carriers Apart from Those Regarding the Breast and the Ovary?
2012
Germline mutations in the tumor suppressor genes BRCA1 and BRCA2 predispose to familial breast and/or ovarian cancer. The lifetime risk of members of families with genetic predisposition depends on the mutations of susceptibility genes. BRCA1 mutations seem to confer the highest risk of developing neoplastic diseases. Apart from breast and ovarian cancer mutations in BRCA, related pathways are supposed to confer a smaller risk for additional cancers (colon, melanoma, pancreas, lymphoma, prostate, liver). All these tumors have an inherited component not necessarily associated with genetic susceptibility to BRCA genes. To date he main focus of this review has been argued still with difficulty…
Hereditary ovarian cancer.
2008
Apoptosis is a form of cell death that permits the removal of damaged, senescent or unwanted cells in multicellular organisms, without damage to the cellular microenvironment. Defective apoptosis represents a major causative factor in the development and progression of cancer. The majority of chemotherapeutic agents, as well as radiation, utilize the apoptotic pathway to induce cancer cell death. Resistance to standard chemotherapeutic strategies also seems to be due to alterations in the apoptotic pathway of cancer cells. Recent knowledge on apoptosis has provided the basis for novel targeted therapies that exploit apoptosis to treat cancer. These new target include those acting in the ext…
From adjuvant to preventive breast cancer treatment: bridging the gap over troubled waters
2006
Recently, chemoprevention trials have demonstrated the efficacy of preventive medical treatment (PMT) in reducing breast cancer (BC) detection rates in at-risk affected and unaffected women selected according to clinical and/or familial risk criteria, particularly with the use of tamoxifen (TAM). Major concerns limiting the routine use of TAM are the questionable benefit/risk ratio and poor patient compliance, which justify the studies undertaken to determine the efficacy of aromatase inhibitors (AIs) with respect to TAM. Issues such as therapy duration, impact on survival, incidence of side-effects and which subsets benefit most from treatment, still remain unsolved. Therefore, only ER+ BC…
Detection of local tourism systems by threshold accepting
2015
Despite the importance of tourism as a leading industry in the development of a country’s economy, there is a lack of criteria and methodologies for the detection, promotion, and governance of local tourism systems. We propose a quantitative approach for the detection of local tourism systems the size of which is optimal with respect to geographical, economic, and demographical criteria: we formulate the problem as an optimisation problem and we solve it by a metaheuristic approach; then we compare the obtained results with standard clustering approaches and with an exact optimisation solver. Results show that our approach requires low computational times to provide results that are better …
Arbitrios frente a la crisis y oposición municipal : El Consejo General de Valencia ante la coyuntura financiera de 1610-1612
2004
A su ya crónico déficit financiero la Ciudad de Valencia sumó desde 1610 los efectos derivados de las acuñaciones clandestinas de “menuts” falsos por los moriscos, las dificultades de abastecimiento de cereal y la falta de numerario, factores que la condujeron a una profunda agudización de la crisis. Para afrontarla, la junta de expertos nombrada al efecto propuso, entre otros arbitrios, la aplicación de nuevas sisas. Esta medida, impuesta finalmente por Felipe III, provocó una fuerte oposición en el Consejo General, algunos de cuyos miembros –en un evidente intento de impedir la imposición de los gravámenes exigidos por el rey se esforzaron en elaborar memoriales que ofrecían soluciones di…
Clustering local tourism systems by threshold acceptance
2015
Despite the importance of tourism as a leading industry in the development of a country’s economy, there is a lack of criteria and methodologies for the detection, promotion and governance of local tourism systems. We propose a quantitative approach for the detection of local tourism systems that are optimal with respect to geographical, economic, and demographical criteria. To this end, we formulate the issue as an optimization problem, and we solve it by means of Threshold Acceptance, a meta-heuristic algorithm which does not require us to predefine the number of clusters and also does not require all geographic areas to belong to a cluster.
Optimal Integration of Hybrid Supercapacitor and IPT System for a Free-Catenary Tramway
2019
The aim of the paper is the study of an optimal integration of a supercapacitor-based storage system and inductive power transfer system for the free-catenary operation of a tramway. Starting from the definition of the topology of inductive power transfer system, we propose and analyze a design procedure for the pads of the inductive power system. In the second part of the paper, an optimal integration strategy for the correct size of on-board supercapacitors and the power of the inductive energy transfer are proposed. The results obtained by means of numerical simulations are discussed. © 2018 IEEE.
Dual orexin receptor blocker suvorexant attenuates hypercapnic ventilatory augmentation in mice
2022
Suvorexant (Belsomra(R)), a dual orexin receptor antagonist widely used in the treatment of insomnia, inhibits the arousal system in the brain. However, the drug’s ventilatory effects have not been fully explored. This study aims to investigate the expression of orexin receptors in respiratory neurons and the effects of suvorexant on ventilation. Immunohistology of brainstem orexin receptor OX2R expression was performed in adult mice (n = 4) in (1) rostral ventral respiratory group (rVRG) neurons projecting to the phrenic nucleus (PhN) retrogradely labeled by Fluoro-Gold (FG) tracer, (2) neurons immunoreactive for paired like homeobox 2b (Phox2b) in the parafacial respiratory group/retrotra…
La salute organizzativa nei contesti sanitari: Un’esperienza di ricerca-intervento.
2011
ABSTRACT - From a psychosocial perspective that is intended to produce both understanding and change, especially involv-ing social actors in the construction of shared meanings, this paper illustrates the results of the first stage of an action research process focused on organizational health. The study has been carried out within an Italian hospital combining both quantitative and qualitative methods. Specifically, the data were gathered through the administration of Multidimensional Organizational Health Questionnaire (n=782) and focus group interviews whose transcripts were analyzed with the software T-Lab. The analysis of collected data has allowed us to trace the organizational health…