Search results for "RCI"
showing 10 items of 16009 documents
Delivery of shNupr1 plasmid by solid lipid nanoparticles reduces the expression of Nupr1 gene in hepatocellular carcinoma cells
2015
Cationic solid lipid nanoparticles complexed with genetic material for liver tumor treatment
2015
Concept Gene therapy is a growing field of medicine with great potential for the treatment of several diseases and it is based on the delivery of nucleic acids (DNA, RNA, etc.,) to specific cells. To achieve their therapeutic effects, the nucleic acids need to cross several biological barriers and be protected from the degradation by nucleases, present in biological fluids and intracellular compartments, to successfully gain access to their intracellular targets. To overcome these hurdles, it is necessary to deliver the genetic material with biocompatible carriers able to facilitate its translocation across the cell membranes and protect it from being degraded while circulating in the blood…
Light and Divine Wisdom: An Alternative Interpretation of the Iconography of the Fuller Brooch
2022
La spilla di Fuller viene considerata una rappresentazione, in ambito inglese, dei cinque sensi. Si ritiene che il personaggio centrale, che rappresenta la vista, presenti anche uno o più significati figurativi, legati a idee e concetti che erano correnti nel contesto culturale di re Alfredo. Questi significati figurativi dovevano presumibilmente essere enfatizzati e chiariti dai due oggetti che questa figura regge. Finora, tuttavia, questi oggetti non sono stati interpretati in modo soddisfacente, anche se la maggior parte degli studiosi ritiene che essi possano rappresentare delle piante o cornucopie. Il presente studio esplora l'ipotesi che questi oggetti siano in realtà delle torce, att…
Large-scale genotyping identifies 41 new loci associated with breast cancer risk
2013
Journal article Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We report here a meta-analysis of 9 genome-wide association studies, including 10,052 breast cancer cases and 12,575 controls of European ancestry, from which we selected 29,807 SNPs for further genotyping. These SNPs were genotyped in 45,290 cases and 41,880 controls of European ancestry from 41 studies in the Breast Cancer Association Consortium (BCAC). The SNPs were genotyped as part of a collaborative genotyping experiment involving four consortia (Collaborat…
Le società in house nel quadro della nozione europea e nazionale di impresa di gruppo
2020
L’articolo si propone di ricostruire in chiave sistematica il concetto di “società in house” nell’ambito del quadro della nozione europea e nazionale di impresa di gruppo. Ricondurre la relazione in house ad un rapporto di gruppo tra due o più imprese dovrebbe comportare, in prima battuta, l’applicazione della cd. single economic entity doctrine e delle sue ricadute in ambito concorrenziale, fra le quali acquista particolare rilievo la potenziale imputazione delle sanzioni antitrust all’ente pubblico capogruppo per le infrazioni compiute dalle società eterodirette. Nell’ordinamento giuridico nazionale, inoltre, la sostanziale convergenza tra il tipo di controllo alla base dell’in house prov…
“Congratulations, you’re on TV!”: Middle-space performances of live tweeters during the FIFA World Cup
2018
Social television has transformed the traditional role of the television viewers by providing ‘ordinary people’ access to the public stage. This article describes how public access to television affected the dialogues of Finnish tweeters on Twitter during the massive media event of the FIFA World Cup. Through the lens of digital conversation analysis, the study shows how the media publicity of tweets changed the direction of the interaction between tweeters and transformed their roles vis-à-vis the television show, making one of them into a ‘media flasher’ and the others viewers of his or her performance. The publicity was constructed as important through noticings, congratulations, and com…
Developments in the biomechanics and equipment of Olympic cross-country skiers
2018
Source at: http://doi.org/10.3389/fphys.2018.00976 Here, our aim was to describe the major changes in cross-country (XC) skiing in recent decades, as well as potential future developments. XC skiing has been an Olympic event since the very first Winter Games in Chamonix, France, in 1924. Over the past decades, considerable developments in skiing techniques and improvements in equipment and track preparation have increased skiing speed. In contrast to the numerous investigations on the physiological determinants of successful performance, key biomechanical factors have been less explored. Today’s XC skier must master a wide range of speeds, terrains, and race distances and formats (e.g., dis…
Skin Immunomodulation during Regeneration: Emerging New Targets
2021
Adipose-Derived Stem Cells (ADSC) are present within the hypodermis and are also expected to play a pivotal role in wound healing, immunomodulation, and rejuvenation activities. They orchestrate, through their exosome, the mechanisms associated to cell differentiation, proliferation, and cell migration by upregulating genes implicated in different functions including skin barrier, immunomodulation, cell proliferation, and epidermal regeneration. ADSCs directly interact with their microenvironment and specifically the immune cells, including macrophages and T and B cells, resulting in differential inflammatory and anti-inflammatory mechanisms impacting, in return, ADSCs microenvironment and …
Aristóteles entre doxografía y biografía: sobre Diógenes Laercio V 31
2019
Se pretende llamar la atención sobre un par de frases que aparecen justo hacia la mitad de la controvertida doxografía de Aristóteles que se puede leer en las Vidas y doctrinas de los filósofos más ilustres de Diógenes Laercio V 31, y que desde luego no corresponden a ningún sistema doxográfico conocido. Como sucede no pocas veces en la obra laerciana, la misma apreciación sobre si el filósofo debe o no enamorarse y contraer matrimonio se repite idéntica en otras doxografías completamente distintas: la cirenaica (DL II 91), la estoica (DL VII 129) y la epicúrea (DL X 118). Cabe plantearse, pues, el origen de este interés, en varias doxografías, por la vida sentimental, podríamos decir, de l…
Social closeness,salivary hormones and physical exercise
2015
Introduction: Saliva collection and analysis is quickly becoming a useful and non-invasive tool for the evaluation of sport biomarkers. The aim of this study is to create a multidisciplinary assessment model, which can help to provide psychological and physiological responses, related to sport performances, social closeness and performance anxiety management in team sports. Materials and methods: We enrolled in our research 26 female volleyball players aged 13 ± 1 years old of three different teams (T1: 12 players; T2: 9 players; T3: 5 players). Saliva collection was carried out before and after the match for every team. Then we analyzed cortisol and progesterone concentrations through Elis…