Search results for "READING"

Temporal Profile of Gene Induction After Venous Ischemia and Effects of Spreading Depression

2004

Occlusion of two adjacent cortical veins is followed by a widespread reduction of rCBF and the occurrence of small infarcts, which become larger if spreading depression (SD) occurs. The infarct matures over time with TUNEL-positive cells seen in the penumbra up to 4 days after vein occlusion. Caspase inhibition with zVAD.fmk reduces infarct size. Here, the time course of gene expression in the penumbra is compared to that induced by SD alone.

Critical Appraisal of Scientific Articles

2009

Despite the increasing number of scientific publications, many physicians find themselves with less and less time to read what others have written. Selection, reading, and critical appraisal of publications is, however, necessary to stay up to date in one’s field. This is also demanded by the precepts of evidence-based medicine (1, 2). Besides the medical content of a publication, its interpretation and evaluation also require understanding of the statistical methodology. Sadly, not even in science are all terms always used correctly. The word "significance," for example, has been overused because significant (or positive) results are easier to get published (3, 4). The aim of this article …

Could audiovisual training be used to improve cognition in extremely low birth weight children?

2011

Aim: To study whether a dyslexia remediation programme, Audilex, improves cognition in extremely low birth (ELBW) children. Methods: Six-year-old ELBW children were allocated to a 5-week training with Audilex or playing control computer games. Before and after intervention, auditory event-related brain potentials (ERP) to sound changes were recorded and reading related skills assessed. Primary outcome was the mismatch negativity (MMN) component of ERP. Secondary outcomes were Audilex Test (ability to perform the Audilex games), the reading skills after the intervention and 2 years later. Of eligible children, 39 (54%) consented and 22 (30%) completed the protocol. Results: The MMN responses…

Neuroplasticity in the Adjustment to Blindness

1999

Loss of vision due to injury to the eyes results in deafferentation of very large areas of the human cortex and poses striking demands on other sensory systems to adjust to blindness in a society that heavily relies on vision. Blind subjects need to extract crucial spatial information from touch and hearing. To accomplish this, plastic trans-modal changes appear to take place by which a larger area of the sensorimotor cortex is devoted to the representation of the reading finger in Braille readers, and parts of the former visual cortex are recruited for the processing of tactile and auditory information.

Mapping symbols to sounds: electrophysiological correlates of the impaired reading process in dyslexia

2012

Dyslexic and control first-grade school children were compared in a Symbol-to-Sound matching test based on a non-linguistic audiovisual training which is known to have a remediating effect on dyslexia. Visual symbol patterns had to be matched with predicted sound patterns. Sounds incongruent with the corresponding visual symbol (thus not matching the prediction) elicited the N2b and P3a event-related potential (ERP) components relative to congruent sounds in control children. Their ERPs resembled the ERP effects previously reported for healthy adults with this paradigm. In dyslexic children, N2b onset latency was delayed and its amplitude significantly reduced over left hemisphere whereas P…

Visual Impairment Is Associated With Depressive Symptoms—Results From the Nationwide German DEGS1 Study

2018

Introduction: Visual impairment is associated with a variety of co-morbidities including physical and mental health in industrial countries. Our aim is to examine associations between self-reported impairment and depressive symptoms in the German population. Methods: The point prevalence of self-reported visual impairment in Germany was computed using data from the German Health Interview and Examination Survey for adults from 2008 to 2011 (N=7.783, 50.5% female, age range 18-79 years). Visual impairment was surveyed by two questions, one for seeing faces at a distance of 4 meters and one for reading newspapers. Depressive symptoms were evaluated with the PHQ-9 questionnaire and two-week pr…

Patient-centered web-based information on oral lichen planus : quality and readability

2019

Background To assess the readability and quality of web-based information available for patients about oral lichen planus (OLP). Material and Methods Three major search engines (Google, Bing and Yahoo!) were used to identify websites of particular interest to the study using the search term ‘oral lichen planus’. The first 100 sites of each search engine were considered for the study. The quality of the contents was evaluated using the DISCERN instrument. The Flesch-Kinkaid Reading Grade Level (FKRGL) and the Flesh Reading Ease Score (FRES) were used to assess readability. The presence of the Health on the Net (HON) seal was also evaluated. Results Following the application of the study’s ex…

Neural Responses to Musical Rhythm in Chinese Children With Reading Difficulties

2020

The perception of the musical rhythm has been suggested as one of the predicting factors for reading abilities. Several studies have demonstrated that children with reading difficulties (RD) show reduced neural sensitivity in musical rhythm perception. Despite this prior evidence, the association between music and reading in Chinese is still controversial. In the present study, we sought to answer the question of whether the musical rhythm perception of Chinese children with RD is intact or not, providing further clues on how reading and music might be interlinked across languages. Oddball paradigm was adapted for testing the difference of musical rhythm perception, including predictable an…

2021

School-age reading skills are associated with and predicted by preschool-age cognitive risk factors for dyslexia, such as deficits in phonological awareness, rapid automatized naming, letter knowledge, and verbal short-term memory. In addition, evidence exists that problems in morphological information processing could be considered a risk factor for dyslexia. In the present study, 27 children at pre-school age and the same 27 children at first grade age performed a morphological awareness task while their brain responses were measured with magnetoencephalography. Our aim was to examine how derivational morphology in Finnish language, and concomitant accuracy and reaction times are associat…

Misunderstandings about developmental dyslexia: a historical overview

2020

Developmental dyslexia is a reading disorder unrelated to intellectual disability, inadequate teaching systems or poor motivation for schooling. The first attempts to understand such difficulty of learning to read, connected the problem to a primary ‘visual defect’. Since then, several models have been developed. In the last decades, autopsy and histopathological studies on the brain of developmental dyslexics provided neuroanatomical evidence of structural and morphological differences between the normal and dyslexic brains. Furthermore, neuroimaging studies allowed to understand the neural systems of reading and dyslexia. According to more recent studies, developmental dyslexia appears as…