Search results for "RED"
showing 10 items of 23890 documents
Harnessing dendritic cells in cancer.
2011
Dendritic cells (DCs) are central to the initiation of tumor-specific immune responses. However, the tumor microenvironment generates immunosuppressive cells and soluble mediators that compromise DC functions and limit the success of DC-based therapies. Progress in understanding DC metabolism in cancer is uncovering novel therapeutic targets that could restore DC capacity to prime T cells and trigger effective anticancer responses. Accumulating evidence also indicates that conventional chemo- and radiotherapy protocols can cause DC activation, enhance antigen cross-presentation, selectively eliminate immunosuppressive cells and revert the immunosuppression state caused by cancer, suggesting…
Descriptive study on subjective experience of genetic testing with respect to relationship, family planning and psychosocial wellbeing among women wi…
2021
AbstractBackgroundDue to increased risk of endometrial and ovarian cancer, women belonging to known Lynch Syndrome (LS) families are recommended to undergo germline testing. Current practice in Finland is to offer counselling to women with pathogenic variant and advocate risk-reducing surgery (RRS) after completion of childbirth. The present study aimed to clarify the impacts of positive germline testing on family planning and reproductive decisions of these women, which are relatively unknown.MethodsSeventy-nine carriers of germline MMR gene pathogenic variant (path_MMR)were identified from the Finnish LS Registry as having genetic testing performed before the age of 45 years and not havin…
Characterization of the Adjuvant Effect of IL-12 and Efficacy of IL-12 Inhibitors in Type II Collagen-Induced Arthritis
1996
A destructive joint disease can be induced in susceptible DBA/1 mice by immunization with type II collagen emulsified with oil and either killed Mycobacterium tuberculosis or IL-12 as adjuvant. Cellular and humoral anti-collagen immune mechanisms appear to be involved in the pathogenesis of arthritis. We have characterized the adjuvant effect or IL-12 in more detail and addressed the question whether mycobacteria might act via the induction of endogenous IL-12. Injections of IL-12 into collagen-immunized DBA/1 mice promoted the development of IFN-gamma-producing CD4+ T cells and strongly upregulated the production of complement-fixing IgG2a and IgG2b antibodies resulting in severe arthritis…
C5a complement and cytokine signaling mediate the pronociceptive effects of complex regional pain syndrome patient IgM in fracture mice.
2020
It has been proposed that complex regional pain syndrome (CRPS) is a posttraumatic autoimmune disease. Previously, we observed that B cells contribute to CRPS-like changes in a mouse tibia fracture model, and that early (12 months duration) CRPS patient IgM antibodies have pronociceptive effects in the skin and spinal cord of muMT fracture mice lacking B cells. The current study evaluated the pronociceptive effects of intraplantar or intrathecal injections of early CRPS IgM (5 µg) in muMT fracture mice. Skin and lumbar spinal cord were collected for immunohistochemistry and polymerase chain reaction analyses. Wild-type mice exhibited postfracture increases in complement component C5a and it…
Perfluoroalkylated amphiphilic MUC1 glycopeptide antigens as tools for cancer immunotherapy.
2010
The synthesis of perfluoroalkylated glycopeptide antigens and their specific binding to anti-MUC1 mouse antibodies is reported.
Efficacy of Computer-Aided Static Navigation Technique on the Accuracy of Endodontic Microsurgery. A Systematic Review and Meta-Analysis
2021
The aim of this systematic review and meta-analysis was to analyze the efficacy of the computer-aided static navigation technique on the accuracy of root apex location in endodontic microsurgery. Material and Methods: A systematic literature review and meta-analysis, based on Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations, of clinical studies that evaluated the apex location rate of the computer-aided static navigation techniques applied to endodontic microsurgery. A total of four databases were consulted in the literature search: Pubmed-Medline, Scopus, Cochrane, and Web of Science. After eliminating duplicated articles and applying the inclusio…
Ķīnas sociālais kredīts kā sabiedrības kontroles instruments
2022
Bakalaura darba “Ķīnas sociālais kredīts kā sabiedrības kontroles instrumets” mērķis ir noteikt, kādus naratīvus saistībā ar sociālo kredītu sistēmu veido vadošie Ķīnas un Āzijas ziņu portāli angļu valodā un noskaidort, vai šajos medijos tie ir atšķirīgi, atsevišķi, analizējot autoritārā, atkarīgā un demokrātiskā, neatkarīgā medja iekļautos naratīvus. Kā papildus mērķis ir izvirzīts notiekt, kādā veidā Ķīna, izmantojot medijus, ir spējīga kontrolēt sabiedrību, tajā notiekošos procesus, pilnībā radot jaunu dzīves vidi. Darba teorētiskajā daļā aprakstīta Ķīnas sociālā kredīta būtība, naratīva teorija un naratoloģijas pielietojums, aprakstīts, kā masu mediji spēj būt sociālās kontroles instrum…
Stability of Thermoelastic Layered Composite in Axial Movement
2018
Znaczenie roślinnych i syntetycznych składników aktywnych we wspomaganiu procesu depigmentacji skóry
2021
Melanogenesis is a process catalyzed by tyrosinase enzyme leading to synthesis of two types of pigment in the skin: black-brown eumelanin and red-yellow pheomelanin. Pheomelanin is synthesized in the second stage of melanosome maturation, while eumelanin-synthesizing melanosomes are inactive. The black-brown pigment is produced in the third stage of melanosome development. The last, fourth stage of melanosome maturation is characterized by low tyrosinase activity, which reflects the low pigment production in the skin. The process of skin pigment production (melanogenesis) is mainly regulated by solar radiation, hormones and other endo- and exogenous factors. Over- stimulated melanogenesis l…
Prevalencia, búsqueda y registro clínico asistencial de pacientes con síndrome de Peutz Jeghers en Valencia
2022
El síndrome de Peutz Jeghers es una enfermedad rara de herencia autosómica dominante causada por una mutación germinal del gen STK11/LKB1, que codifica para una proteína serina/treonina/kinasa. Consiste en poliposis hamartomatosa intestinal y extraintestinal, predisposición al cáncer e hiperpigmentación mucocutánea. Se asocia a complicaciones como dolor abdominal, sangrados gastrointestinales, anemia, prolapso y ulceración de los pólipos, obstrucción e invaginación intestinal. No existe ningún tratamiento específico, solamente la adecuada instauración de protocolos. Se incluyeron pacientes que habían acudido a 10 hospitales de la provincia de Valencia, utilizando el Conjunto Mínimo de Base …