Search results for "RED"
showing 10 items of 23890 documents
Tietokoneavusteinen mallinnus rakenteisten asiakirjastandardien kehittämisessä
1998
Translation of HTT mRNA with expanded CAG repeats is regulated by the MID1-PP2A protein complex.
2012
Expansion of CAG repeats is a common feature of various neurodegenerative disorders, including Huntington's disease. Here we show that expanded CAG repeats bind to a translation regulatory protein complex containing MID1, protein phosphatase 2A and 40S ribosomal S6 kinase. Binding of the MID1-protein phosphatase 2A protein complex increases with CAG repeat size and stimulates translation of the CAG repeat expansion containing messenger RNA in a MID1-, protein phosphatase 2A- and mammalian target of rapamycin-dependent manner. Our data indicate that pathological CAG repeat expansions upregulate protein translation leading to an overproduction of aberrant protein and suggest that the MID1-com…
Model, software and database for line-mixing effects in the ν3 and ν4 bands of CH4 and tests using laboratory and planetary measurements-I: N2(and ai…
2006
International audience; Absorption spectra of the infrared ν3 and ν4 bands of CH4 perturbed by N2 over large ranges of pressure and temperature have been measured in the laboratory. A theoretical approach accounting for line mixing is proposed to (successfully) model these experiments. It is similar to that of Pieroni et al. [J Chem Phys 1999;110:7717–32] and is based on state-to-state rotational cross-sections calculated with a semi-classical approach and a few empirical parameters. The latter, which enable switching from the state space to the line space, are deduced from a fit of a single room temperature spectrum of the ν3 band at 50 atm. The comparisons between numerous measured and ca…
Isolation and Culture of Oligodendrocytes
2019
Primary cultures of brain-derived rodent cells are widely used to study molecular and cellular mechanisms in neurobiology. In this chapter, we describe methods of purifying and culturing oligodendroglial cells from mouse perinatal brains. In addition, we describe methods of coculturing the purified oligodendrocytes with neurons. When prepared and cultured according to these protocols, many essential aspects of the biology of oligodendrocytes, such as their proliferation, differentiation, and myelination, can be studied in culture.
Amplicon-based high-throughput pooled sequencing identifies mutations in CYP7B1 and SPG7 in sporadic spastic paraplegia patients
2011
Hereditary spastic paraplegia (HSP) is a neurodegenerative disorder defined clinically by progressive lower limb spasticity and weakness. HSP is a genetically highly heterogeneous condition with at least 46 gene loci identified so far, involving X-linked, autosomal recessive (AR) and autosomal dominant inheritance. For correct diagnosis, molecular testing is essential because clinical parameters by themselves are not reliable to differentiate HSP forms. The purpose of this study was to establish amplicon-based high-throughput genotyping for AR-HSP. A sample of 187 index cases with apparently sporadic or recessive spastic paraplegia were analyzed by applying an array-based amplification stra…
Mechanisms of population declines in boreal forest grouse
2007
Gilbert Ludwig tutki väitöskirjassaan, miksi kanalinnut ovat vähentyneet talousmetsissä. Suomen metsäkanalintukannat ovat vähentyneet merkittävästi viimeisen 40 vuoden ajan. Pesiin ja poikasiin kohdistuvaa saalistusta on pidetty tärkeimpänä syynä kanalintukantojen laskuun. Hakkuiden ja nuorten metsien osuuden lisääntymisen on katsottu lisänneen myyräkantoja ja niitä syöviä petoja, kuten kettuja, lisäten näin myös kanalintujen pesiin ja poikasiin kohdistuvaa saalistusta. Vuosikymmenten aikana laskenut poikastuotto on keskeisessä roolissa kanalintukantojen laskussa. - Ainakaan teerellä vuotuinen aikuiskuolleisuus ei ole lainkaan lisääntynyt. Hengissäsäilyminen on päinvastoin jopa parantunut, …
Automašīnas gaismas ietekme uz redzes asumu miopijas gadījumā mezopiskos gaismas apstākļos
2018
Maģistra darbs rakstīts latviešu valodā uz 28 lapām, satur 18 attēlus un 84 atsauces uz literatūras avotiem. Darba mērķis: izpētīt, kā mainās redzes asums fotopiskos apstākļos salīdzinot ar mezopiskiem apstākļiem un apstākļos, kad uz dalībnieku tiek izstarota automašīnas luktura gaisma. Metode: uzdevumā redzes asums tika noteikts FrACT programmā uz datora ekrāna. Tests sastāv no baltiem Landolta gredzena optotipiem uz melna fona. Redzes asums tika salīdzināts fotopiskos, mezopiskos un no automašīnas luktura izstarotā ksenona un halogēnās spuldzes apgaismojuma apstākļos. Secinājumi: Mezopiskos apstākļos redzes asums ir zemāks nekā fotopiskos apstākļos. Halogēnas gaismas ietekme uz redzes asu…
Postnatal predator exposure reduces fear and anxiety behaviors in adult mice
2010
Poster; Predator cues are very efficient to induce fear in rodents but most studies use adult subjects and not pups. Nevertheless, a perinatal stress can have a significant effect on behavior and on physiology at adulthood. An early stress (foot shock, restraint, mother separation) is able to modulate behaviors later and the aim of this study was to examine if the synthetic predator odor 2,3,5-trimethylthiazoline (TMT) presented to neonates modifies fear and anxiety-related behaviors in adult female mice.
Development of economic MeV-ion microbeam technology at Chiang Mai University
2017
Developing high technologies but in economic manners is necessary and also feasible for developing countries. At Chiang Mai University, Thailand, we have developed MeV-ion microbeam technology based on a 1.7-MV Tandetron tandem accelerator with our limited resources in a cost-effective manner. Instead of using expensive and technically complex electrostatic or magnetic quadrupole focusing lens systems, we have developed cheap MeV-ion microbeams using programmed L-shaped blade aperture and capillary techniques for MeV ion beam lithography or writing and mapping. The programmed L-shaped blade micro-aperture system consists of a pair of L-shaped movable aperture pieces which are controlled by …
Chemical composition and microencapsulation suitability of sumac (Rhus coriaria L.) fruit extract
2021
Sumac (Rhus coriaria L.), a spice obtained by grinding whole sumac berries, is a complex natural product with a plethora of biological activities that can be favorably explored in nutraceutical and pharmaceutical fields. Sicilian sumac is herein chemically investigated by means of a combined NMR/HR MS-based profiling. A hydroalcoholic extract was prepared and its complexity unraveled following fractionation in an alcoholic and an aqueous fraction. The 1H-NMR spectrum of this latter fraction was dominated by the signals of gallic acid and its derivatives, whereas HR MS and HR MS/MS analyses highlighted the diversity in malic acid derivatives. Gallotannins and galloyl flavonol glycosides with…