Search results for "RED"

Antitumor Cell-Complex Vaccines Employing Genetically Modified Tumor Cells and Fibroblasts

2014

The present study evaluates the immune response mediated by vaccination with cell complexes composed of irradiated B16 tumor cells and mouse fibroblasts genetically modified to produce GM-CSF. The animals were vaccinated with free B16 cells or cell complexes. We employed two gene plasmid constructions: one high producer (pMok) and a low producer (p2F). Tumor transplant was performed by injection of B16 tumor cells. Plasma levels of total IgG and its subtypes were measured by ELISA. Tumor volumes were measured and survival curves were obtained. The study resulted in a cell complex vaccine able to stimulate the immune system to produce specific anti-tumor membrane proteins (TMP) IgG. In the g…

Wiener-Granger Causality in Network Physiology with Applications to Cardiovascular Control and Neuroscience

2016

Since the operative definition given by C. W. J. Granger of an idea expressed by N. Wiener, the Wiener–Granger causality (WGC) has been one of the most relevant concepts exploited by modern time series analysis. Indeed, in networks formed by multiple components, working according to the notion of segregation and interacting with each other according to the principle of integration, inferring causality has opened a window on the effective connectivity of the network and has linked experimental evidences to functions and mechanisms. This tutorial reviews predictability improvement, information-based and frequency domain methods for inferring WGC among physiological processes from multivariate…

Theoretical and experimental study of two discrete coupled Nagumo chains

2001

We analyze front wave (kink and antikink) propagation and pattern formation in a system composed of two coupled discrete Nagumo chains using analytical and numerical methods. In the case of homogeneous interaction among the chains, we show the possibility of the effective control on wave propagation. In addition, physical experiments on electrical chains confirm all theoretical behaviors.

Signal dimension estimation in BSS models with serial dependence

2022

Many modern multivariate time series datasets contain a large amount of noise, and the first step of the data analysis is to separate the noise channels from the signals of interest. A crucial part of this dimension reduction is determining the number of signals. In this paper we approach this problem by considering a noisy latent variable time series model which comprises many popular blind source separation models. We propose a general framework for the estimation of the signal dimension that is based on testing for sub-sphericity and give examples of different tests suitable for time series settings. In the inference we rely on bootstrap null distributions. Several simulation studies are…

Evidence of energy and nutrient transfer from invasive pink salmon (Oncorhynchus gorbuscha) spawners to juvenile Atlantic salmon (Salmo salar) and br…

2021

Recent large influxes of non‐native Pacific pink salmon (Oncorhynchus gorbuscha) to North European rivers have raised concern over their potential negative impacts on native salmonids and recipient ecosystems. The eggs and carcasses of semelparous pink salmon may provide a significant nutrient and energy subsidy to native biota, but this phenomenon has not been widely documented outside the species' native distribution. We analysed the stomach contents and stable isotope values (δ15N and δ13C) in muscle and liver tissues of juvenile Atlantic salmon (Salmo salar) and brown trout (Salmo trutta) to determine whether these native salmonids utilise marine‐derived nutrients and energy provided by…

Norēķinu karšu tirgus analīze Latvijā

2017

Bakalaura darba “Norēķinu karšu tirgus analīze Latvijā” mērķis ir izpētīt kredītkaršu un debetkaršu piedāvājumu Latvijā, izmantojot Latvijas lielāko komercbanku piedāvājumus, kuras šobrīd dominē norēķinu karšu tirgū, un analizēt iedzīvotāju norēķinu karšu izvēli dažādos iedzīvotāju segmentos un apmierinātību ar maksājumu kartēm. Mērķa sasniegšanai izvirzītie uzdevumi ir saistīti gan ar pieejamās literatūras izpēti un analīzi, gan arī ar aptaujā iegūto rezultātu analīzi. Šī tēma tika izvēlēta, jo mūsdienu sabiedrībā norēķinu kartes ir neatņemama ikdienas sastāvdaļa. Maksājumu karšu attīstība pasaulē pēdējo gadu laikā ir bijusi strauja gan karšu skaita pieaugumā, gan piedāvāto iespēju daudzve…

Glosa do wyroku Sądu Najwyższego z dnia 11 kwietnia 2017 r., II KK 35/17

2017

Novecošanas pieredzes un vientulības saistība ar psiholoģisko labklājību

2022

Pētījuma mērķis bija noskaidrot novecošanas pieredzes, vientulības un psiholoģiskās labklājības saistību. Izlasi veidoja 314 respondenti, no tiem 174 sievietes. Izmantotas: Novecošanas pieredzes aptauja (Awareness of Age-Related Change questionnaire short form (AARC-SF), adaptējusi Stūre, 2022, šī pētījuma ietvaros), Psiholoģiskās labklājības skala (Scales of Psychological Well-Being, adaptējusi Voitkāne, Miezīte, 2003 (Raščevska et al., 2003)), De Žongas – Ģīrvildes vientulības aptauja (JGLS, adaptējusi Krūmale, 2012). Rezultāti liecina, ka pastāv saistība starp vientulību un psiholoģisko labklājību, starp novecošanas pieredzes ieguvumiem un zaudējumiem un vientulību, starp novecošanas pie…

Explaining Causes Behind SQL Query Formulation Errors

2020

This Full Research Paper presents the most prominent query formulation errors in Structured Query Language (SQL), and maps these errors to their cognitive explanations. Understanding query formulation errors is a key to teaching SQL. more effectively. However, studies on what kind of errors novices struggle with are relatively scarce when compared to, for example, programming languages. Although committing errors is a crucial part in learning, some errors are relatively easy to fix, and their commonness is not necessarily an indication of their difficulty. Other errors, however, halt the learning process, and are never fixed by the query writer. Using a previously established error taxonomy…

Ar neatliekamās medicīniskās palīdzības brigādēm stacionārā nogādāto pacientu apmierinātība ar veselības aprūpi pirms stacionāra un stacionāra etapā

2017

Autore: Dace Dzene, stud.apl.nr. dd15034 Darba vadītājs: Dr.med. Igors Ivanovs Ar neatliekamās medicīniskās palīdzības brigādēm stacionārā nogādāto pacientu apmierinātība ar veselības aprūpi pirms stacionāra un stacionāra etapā. Maģistra darbs, Latvijas universitāte, Rīga, 2017. Darbs sastāv no teorētiskās un empīriskās daļas, 6 nodaļām, 66 lapām, 29 attēliem, 10 tabulām, 2 pielikumiem. Pētījuma mērķis ir noskaidrot pacientu apmierinātību ar saņemto veselības aprūpes kvalitāti pirms stacionāra un stacionāra etapā. Maģistra darbā tiek izvirzīts pētījuma jautājums, ka pacienti nav apmierināti ar saņemto veselības aprūpes kvalitāti pirms stacionāra un stacionāra etapā. Pētījuma bāze ir daudzpr…