Search results for "REGENERATION"
showing 10 items of 889 documents
Mild Aerobic Exercise Training Hardly Affects the Diaphragm ofmdxMice
2017
In the mdx mice model of Duchenne Muscular Dystrophy (DMD), mild endurance exercise training positively affected limb skeletal muscles, whereas few and controversial data exist on the effects of training on the diaphragm. The diaphragm was examined in mdx (C57BL/10ScSn-Dmdmdx) and wild-type (WT, C57BL/10ScSc) mice under sedentary conditions (mdx-SD, WT-SD) and during mild exercise training (mdx-EX, WT-EX). At baseline, and after 30 and 45 days (training: 5 d/wk for 6 weeks), diaphragm muscle morphology and Cx39 protein were assessed. In addition, tissue levels of the chaperonins Hsp60 and Hsp70 and the p65 subunit of nuclear factor-kB (NF-kB) were measured in diaphragm, gastrocnemius, and q…
Lack of Dystrophin Affects Bronchial Epithelium inmdxMice
2016
Mild exercise training may positively affect the course of Duchenne Muscular Dystrophy (DMD). Training causes mild bronchial epithelial injury in both humans and mice, but no study assessed the effects of exercise in mdx mice, a well known model of DMD. The airway epithelium was examined in mdx (C57BL/10ScSn-Dmdmdx) mice, and in wild type (WT, C57BL/10ScSc) mice either under sedentary conditions (mdx-SD, WT-SD) or during mild exercise training (mdx-EX, WT-EX). At baseline, and after 30 and 45 days of training (5 d/wk for 6 weeks), epithelial morphology and markers of regeneration, apoptosis, and cellular stress were assessed. The number of goblet cells in bronchial epithelium was much lower…
Angiogenesis control in spine regeneration
2012
Abstract: The intervertebral disc (IVD) has a complex vascularisation pattern. While the nucleus pulposus is avascular, the annulus fibrosus as well as the endplates are vascularised. IVD degeneration is often accompanied, on the one hand, by blood vessel ingrowth into the nucleus pulposus and, on the other hand, by diminished vascularisation of the endplates. Tissue engineering of IVD, therefore, has to address the differences in the vascularisation of IVD compartments. This chapter summarises current knowledge about the mechanisms of angiogenesis and its physiological and pathological role in IVD biology. Different strategies to control angiogenesis are discussed in the chapter with examp…
Repair of osteochondral defects in articular weightbearing areas in the rabbit's knee. The use of autologous osteochondral and meniscal grafts.
1987
Repair of osteochondral defects in articular weightbearing areas presents its own particular problems because of the low potential of hyaline cartilage for regeneration. Our first group of experiments on the knee of the rabbit confirms that the new regenerated cartilage comes from bone marrow which degenerates before developing into true hyaline cartilage. The second group of experiments shows that autologous grafts from the non-weightbearing articular area suitable for the repair of defects in weightbearing areas. In an third group, autologous meniscal fibrocartilage was used as a graft for the repair of osteochondral defects.
I fattori di rischio per la biodiversità forestale in Sicilia: il caso studio del cerro di Gussone
2011
Il cerro di Gussone (Quercus Gussonei (Borzì) Brullo) è una specie endemica della Sicilia esclusiva della catena dei Nebrodi e del bosco della Ficuzza. Il presente studio ha esaminato la rinnovazione di questa pianta, nella Riserva Naturale Orientata “Bosco della Ficuzza, Rocca Busambra, Bosco del Cappelliere, Gorgo del Drago”. Si tratta di una formazione boschiva monoplana che mostra chiari segni di deperimento. Per isolare i fattori che influenzano la rinnovazione e la crescita delle giovani piantine è stato eseguito un piano di trattamenti. Il risultato dello studio ha confermato che la rinnovazione si afferma in parte e, soprattutto, le giovani piantine non si accrescono a causa della p…
The lizard cerebral cortex as a model to study neuronal regeneration
2002
The medial cerebral cortex of lizards, an area homologous to the hippocampal fascia dentata, shows delayed postnatal neurogenesis, i.e., cells in the medial cortex ependyma proliferate and give rise to immature neurons, which migrate to the cell layer. There, recruited neurons differentiate and give rise to zinc containing axons directed to the rest of cortical areas, thus resulting in a continuous growth of the medial cortex and its zinc-enriched axonal projection. This happens along the lizard life span, even in adult lizards, thus allowing one of their most important characteristics: neuronal regeneration. Experiments in our laboratory have shown that chemical lesion of the medial cortex…
Recent progress in metal-organic frameworks (MOFs) for CO2 capture at different pressures
2022
Global climate change ensued by the rise in atmospheric CO2 levels is one of the greatest challenges our planet is facing today. This worldwide distress demands technologies that can contribute to our society toward “negative carbon emissions”. Carbon capture and storage (CCS) technologies are in in important role for capturing CO2 from existing emission sources, such as industrial and energy production point sources, before new more prominent modifications to the energy infrastructure can be implemented. Recently, alongside point source capture, direct air capture (DAC) processes have emerged as highly sought-after technologies that are able to capture CO2 from the ambient air. Alongside t…
A Continuous Pore Size Gradient PLLA Scaffold For Osteochondral Regeneration
2016
Osteochondral (OC) scaffold-based regenerative approaches in the joint are challenging since the scaffold must provide mechanical strength while also mimicking the local cartilage and bone microenvironments. Thermally Induced Phase Separation (TIPS) can produce scaffolds with a wide range of pore size morphologies/distributions. Here, we produced by TIPS a poly-L-lactide (PLL A) scaffold with a continuous pore size gradient along the sample thickness, from ~70μm diameter on one side to ~200 μm diameter on the opposite surface.
Nuove strategie per il bene collettivo: crowdfunding civico al Parco Uditore di Palermo
2015
Il tema del crowdfunding civico riguarda la partecipazione pubblica alla gestione del territorio. In particolare, la possibilità di attuare meccanismi di finanziamento autonomi e autogestiti per la realizzazione di opere pubbliche (seppure di limitata entità) costringe gli amministratori e i tecnici a confrontarsi con l’avvenuta conquista, da parte della cittadinanza, di una parte del potere decisionale. Quanto è opportuno che gli esiti della consultazione pubblica abbiano un canale di finanziamento specifico? Quali garanzie del processo partecipativo sono necessarie perché le richieste dei cittadini siano coerenti con le linee generali della pianificazione locale e sovralocale, e si possan…
Rimettere in valore gli spazi pubblici del territorio agrigentino
2015
The contemporary city poses a question about regeneration which increasingly finds its answer within the open spaces, where values and potential are recognized not only in ecological and environmental terms but also in terms of agricultural production. However these areas may have consequences on global sustainability and local urban-welfare, provoking identification processes with the places and regenerating the local identities as the only guarantee of survival in a harmonic territory. The research hypothesis is that the coastal areas and peri-urban spaces could contribute substantially to society and sustainable urban development as well as having an impact on social, physical, environme…