Search results for "REGIONS"
showing 10 items of 1521 documents
Workshop on ICES reference points (WKREF2)
2022
The ICES Workshop on ICES reference points (WKREF2) was tasked review the WKREF1 report and based on the outcome develop updated guidelines for the ICES reference points system and recommendations for ACOM consideration. The WKREF1 report has suggested 5 key recommendations to simplify and harmonise the ICES reference points framework representing a major change to the current guidelines. At WKREF2, we detailed discussions and four key concerns were raised about the proposed approach. The first related to the simplification of rules to define Blim. Around two thirds of category 1 stocks would end up as WKREF1 “Blim Type 2” where Blim would be set as a fraction of B0. The Allee effect or “de…
Expression of the Anti-amyloidogenic Secretase ADAM10 Is Suppressed by Its 5′-Untranslated Region*
2010
Proteolytic processing of the amyloid precursor protein by alpha-secretase prevents formation of the amyloid beta-peptide (Abeta), which is the main constituent of amyloid plaques in brains of Alzheimer disease (AD) patients. alpha-Secretase activity is decreased in AD, and overexpression of the alpha-secretase ADAM10 (a disintegrin and metalloprotease 10) in an AD animal model prevents amyloid pathology. ADAM10 has a 444-nucleotide-long, very GC-rich 5'-untranslated region (5'-UTR) with two upstream open reading frames. Because similar properties of 5'-UTRs are found in transcripts of many genes, which are regulated by translational control mechanisms, we asked whether ADAM10 expression is…
Dupuytren contracture in diabetic hand
2011
Dupuytren's disease (DD) is a fibroproliferative disorder of unknown origin causing palmar nodules and flexion contracture of the digits. About 5% of individuals with DD are diabetic, with an increased prevalence that is proportional to the duration of the diabetes. The association with diabetes mellitus is well recorded, with a reported prevalence of between 3% and 32%. This review considers the evidence behind the association between DD and diabetes mellitus, considering the pathogenesis, clinical manifestations and therapies that can be found in the literature.
The competitive development of flowers and ornamentals firms through the use of web-marketing strategies: a survey in the convergence objective regio…
2011
The growth of ICT, and in particular the integrated use of internet within firm marketing strategies, has brought about deep changes at both sector and firm level. Firm processes have been drastically modified in their communication and promotional aspects. In particular, firmcustomer relationships are changing and therefore internet represents a preferential means, not only for transferring the firm image in the global communication, but above all in order to build a dialogue and a continuous interaction which contribute to consumers’ fidelization. This empirical research proposal is to be considered in the framework of “Business to Consumer” relationships and is addressed to the flowers a…
Response of an arctic predator guild to collapsing lemming cycles
2012
6 pages; International audience; Alpine and arctic lemming populations appear to be highly sensitive to climate change, and when faced with warmer and shorter winters, their well-known high-amplitude population cycles may collapse. Being keystone species in tundra ecosystems, changed lemming dynamics may convey significant knock-on effects on trophically linked species. Here, we analyse long-term (1988-2010), community-wide monitoring data from two sites in high-arctic Greenland and document how a collapse in collared lemming cyclicity affects the population dynamics of the predator guild. Dramatic changes were observed in two highly specialized lemming predators: snowy owl and stoat. Follo…
Monitoring of persistent organic pollutants in the polar regions: knowledge gaps & gluts through evidence mapping
2017
Persistent organic pollutants (POPs) are widespread compounds that accumulating in polar regions canalise through trophic webs. Although several dozens of studies have been carried out in the last decades, the information is generally scattered across a large number of literature sources. This does not allow an efficient synthesis and constraints our understanding on how address future monitoring plans and environmental conservation strategies on the Polar Regions with respect to POPs. Thus, here, we present the outcome of a systematic map (SM) to scope, screen and chart evidences from literature dealing with POPs in Polar regions. The SMs strive to produce rigorous guidelines and have rece…
Trophic transfer of polychlorinated biphenyls (PCB) in a boreal lake ecosystem: Testing of bioaccumulation models
2013
Understanding the fate of persistent organic chemicals in the environment is fundamental information for the successful protection of ecosystems and humans. A common dilemma in risk assessment is that monitoring data reveals contaminant concentrations in wildlife, while the source concentrations, route of uptake and acceptable source concentrations remain unsolved. To overcome this problem, different models have been developed in order to obtain more precise risk estimates for the food webs. However, there is still an urgent need for studies combining modelled and measured data in order to verify the functionality of the models. Studies utilising field-collected data covering entire food we…
Free radical-mediated systemic immunity in plants.
2014
SPE IPM; Systemic acquired resistance (SAR) is a form of defense that protects plants against a broad-spectrum of secondary infections by related or unrelated pathogens. SAR related research has witnessed considerable progress in recent years and a number of chemical signals and proteins contributing to SAR have been identified. All of these diverse constituents share their requirement for the phytohormone salicylic acid, an essential downstream component of the SAR pathway. However, recent work demonstrating the essential parallel functioning of nitric oxide (NO)-derived and reactive oxygen species (ROS)-derived signaling together with SA provides important new insights in the overlapping …
Large Eddy Simulations of Rough Turbulent Channel Flows Bounded by Irregular Roughness: Advances Toward a Universal Roughness Correlation
2020
The downward shift of the mean velocity profile in the logarithmic region, known as roughness function, $$\Delta U^+$$ , is the major macroscopic effect of roughness in wall bounded flows. This speed decrease, which is strictly linked to the friction Reynolds number and the geometrical properties which define the roughness pattern such as roughness height, density, shape parameters, has been deeply investigated in the past decades. Among the geometrical parameters, the effective slope (ES) seems to be suitable to estimate the roughness function at fixed friction Reynolds number, Re $$_{\tau }$$ . In the present work, the effects of several geometrical parameters on the roughness function, i…
Comparison of the structure of the plasma-facing surface and tritium accumulation in beryllium tiles from JET ILW campaigns 2011-2012 and 2013-2014
2019
In this study, beryllium tiles from Joint European Torus (JET) vacuum vessel wall were analysed and compared regarding their position in the vacuum vessel and differences in the exploitation conditions during two campaigns of ITER-Like-Wall (ILW) in 2011-2012 (ILW1) and 2013-2014 (ILW2) Tritium content in beryllium samples were assessed. Two methods were used to measure tritium content in the samples - dissolution under controlled conditions and tritium thermal desorption. Prior to desorption and dissolution experiments, scanning electron microscopy and energy dispersive x-ray spectroscopy were used to study structure and chemical composition of plasma-facing-surfaces of the beryllium sampl…