Search results for "REGIONS"

Salivary Testosterone and Cortisol as Biomarkers for the Diagnosis of Sarcopenia and Sarcopenic Obesity in Community-Dwelling Older Adults

2021

Nowadays, the appearance of sarcopenia (S) or sarcopenic obesity (SO) is related to aging. According to the criteria of the European Working Group on Sarcopenia in Older People (EWGSOP), the feasibility of using salivary cortisol and testosterone levels was analyzed as diagnostic biomarkers of S or SO. One hundred and ninety non-institutionalized people aged &ge

Changes in health, functional performance and activity predict changes in self-rated health: a 10-year follow-up study in older people.

2001

Abstract The purpose was to examine changes in self-rated health (SRH) in older people and associations between these changes and various self-reported and objectively measured indicators of health status, functional performance and activity at three time-points 5 years apart. Further, our aim was to examine whether SRH takes the form of a continuum. The study group comprised all the baseline 75-year-old inhabitants of the City of Jyvaskyla, Finland (N=382). Four groups were formed according to change/stability in SRH: ‘good–good’, ‘good–bad’, ‘bad–good’ and ‘bad–bad’. Cross-tabulation and one-way analysis of variance (ANOVA) was used to examine the cross-sectional differences, and GLM Repe…

2020

No previous study has explored the structure of self-rated health (SRH), a measure holding strong predictive value for future health events, in the oldest old or in individuals with dementia. The aim was to construct a structural equation model of SRH for oldest old in general and for oldest old with dementia, and to explore direct and indirect associations between health-related factors and SRH. Cross-sectional data from the Vitality 90+, a population-based study in the city of Tampere, Finland, was used. Data were gathered by a mailed questionnaire in 2014. Altogether 1299 nonagenarians, of which 408 had self-reported dementia or cognitive decline, were included. Structural equation model…

A high dietary glycemic index increases total mortality in a Mediterranean population at high cardiovascular risk

2014

© 2014 Castro-Quezada et al. Objective: Different types of carbohydrates have diverse glycemic response, thus glycemic index (GI) and glycemic load (GL) are used to assess this variation. The impact of dietary GI and GL in all-cause mortality is unknown. The objective of this study was to estimate the association between dietary GI and GL and risk of all-cause mortality in the PREDIMED study. Material and Methods: The PREDIMED study is a randomized nutritional intervention trial for primary cardiovascular prevention based on community-dwelling men and women at high risk of cardiovascular disease. Dietary information was collected at baseline and yearly using a validated 137-item food freque…

Great Recession and club convergence in Europe: A cross‐country, cross‐region panel analysis (2000–2015)

2020

The paper aims at investigating the impact of the Great Recession on per capita GDP convergence process across European regions and countries. Using the time-varying factor model developed by Phillips and Sul for the period 2000–2015 and two different merging procedures to identify clubs, we provide evidence of the diverging impact of the Great Recession “between” the higher and the lower convergence clubs at both regional and country levels as well as of the strengthening of the convergence process “within” most clubs. In addition, we add further evidence to the common belief of a “multi-speed” Europe by contrasting Eastern European countries' and regions' behavior vis-à-vis original Europ…

Spatial autocorrelation and the selection of simultaneous autoregressive models

2007

Aim Spatial autocorrelation is a frequent phenomenon in ecological data and can affect estimates of model coefficients and inference from statistical models. Here, we test the performance of three different simultaneous autoregressive (SAR) model types (spatial error = SAR err , lagged = SAR lag and mixed = SAR mix ) and common ordinary least squares (OLS) regression when accounting for spatial autocorrelation in species distribution data using four artificial data sets with known (but different) spatial autocorrelation structures. Methods We evaluate the performance of SAR models by examining spatial patterns in model residuals (with correlograms and residual maps), by comparing model para…

Differential expression of the invertase-encoding SUC genes in Saccharomyces cerevisiae

1992

Invertase (INV) is encoded in Saccharomyces cerevisiae by a family of genes, comprising SUC1-SUC5 and SUC7. Production of INV is highly variable, dependent on the strain and SUC gene present in the cell. The differences in INV production derive from the structure of the genes or are dependent on the genetic background of the strain. Centromeric plasmids (based on YCp50) carrying one of the SUC genes (except SUC7) were introduced into a strain (SEY2101) lacking SUC genes. The INV produced by the transformants was dependent on the individual SUC genes, and correlated with INV mRNA levels. Plasmids in which SUC2 had been placed under control of promoters from the other SUC genes, were used to …

España inacabada. Organización territorial del Estado, autonomía política y reconocimiento de la diversidad nacional

2021

S’han complert més de tres dècades de vigència de la Constitució de 1978 i, per tant, ja es disposa de prou perspectiva per analitzar el grau d’eficàcia d’un model d’Estat, per alguns, gairebé federal i, per a uns altres, senzillament molt descentralitzat. D’altra banda, a Espanya segueix plenament obert el debat sobre Espanya. Sigui quina sigui l’opinió, la veritat és que el nostre antic problema consumeix una gran part de les energies col·lectives, condiciona àmpliament l’agenda política, genera notables tensions socials i projecta ombres d’incertesa respecte al futur. En aquest treball, s’hi presenta un balanç de les dues qüestions. Després d’oferir un resum breu del procés de construcci…

Demystifying the Possibilities of ICT4D in the Mountain Regions of Nepal

2011

Author's version of a chapter in the book: Proceedings of the 44th Hawaii International Conference on System Sciences. Also available from the publisher at: http://dx.doi.org/10.1109/HICSS.2011.142 Despite the substantial investments in ICT4D projects in developing countries, the benefits are yet to be realised by the majority of remote communities. Inaccessibility to ICT has widened educational, healthcare, information, and communication gaps between urban and remote communities. This paper focuses on an interpretive case study in Nepal to widen our understanding of how locally-initiated ICT4D projects may help to narrow these gaps. The study utilises the Assets Pentagon Model to identify …

Widespread transcriptional gene inactivation initiated by a repair intermediate of 8-oxoguanine.

2016

DNA damage can significantly modulate expression of the affected genes either by direct structural interference with transcription components or as a collateral outcome of cellular repair attempts. Thus, DNA glycosylases of the base excision repair (BER) pathway have been implicated in negative transcriptional response to several spontaneously generated DNA base modifications, including a common oxidative DNA base modification 8-oxoguanine (8-oxoG). Here, we report that single 8-oxoG situated in the non-transcribed DNA strand of a reporter gene has a pronounced negative effect on transcription, driven by promoters of various strength and with different structural properties, including viral…