Search results for "RELATION"
showing 10 items of 10542 documents
Two-pronged strategy
2004
Publikacijoje analizuojamas Latvijos požiūris į lietuvių ir lenkų santykius 1920 m. įvykių metu. 1920 m. rugsėjį latvių politikai turėjo ketinimų pagerinti Baltijos regiono šalių santykius su Sovietų Rusija, tačiau generolo L. Želigovskio kariniai veiksmai Vilniaus krašte palaidojo bet kokias viltis. Latvijos vyriausybė lietuviams ir lenkams siūlė susitikti deryboms Rygoje, bet lenkai atsisakė. Buvo spėjama, kad L Želigovskis palaiko ryšius su Varšuva. Latviai labai norėjo išvengti bet kokio konflikto su lenkais ir įvairiomis priemonėmis bei būdais to siekė. Atkreipiamas dėmesys, kad latviai neleido savo spaudoje paskelbti Lietuvos diplomatų pareiškimų, kuriuose buvo nepalankus požiūris į l…
Lithuanian armed forces in Ilūkstė region in 1919–1920
2006
Dalį Ilūkstės apskrities lenkų ir lietuvių karinės pajėgos okupavo 1919 m. vasarą. Lenkų valdžios įstaigos nedelsdamos įtraukė 6 apskrities rytinės dalies valsčius ir Gryvos miestą į savo valstybės sudėtį ir atsisakė svarstyti šį klausimą su Latvijos atstovais. Klausimas buvo išspręstas tiktai 1920 m. liepos pradžioje, kai dėl Raudonosios armijos puolimo lenkų kariuomenė buvo priversta pasitraukti iš Ilūkstės apskrities. Tuo pasinaudojo Latvijos pusė, tuo momentu pagal savo galimybes užimdami dalį tos teritorijos. Likusią užėmė lietuviai, kurie jau nuo 1919 m. vasaros buvo rūpimoje Ilūkstės apskrities dalyje. Nors derybose tarp Latvijos ir Lietuvos buvo deklaruota, kad sienos tarp tų valsty…
Molecular docking and pharmacogenomics of vinca alkaloids and their monomeric precursors, vindoline and catharanthine.
2011
International audience; Vinblastine and vincristine are dimeric indole alkaloids derived from (formerly: ). Their monomeric precursor molecules are vindoline and catharanthine. While vinblastine and vincristine are well-known mitotic spindle poisons, not much is known about vindoline and catharanthine. Vindoline and catharanthine showed weak cytotoxicity, while vinblastine, vincristine, and the semisynthetic vindesine and vinorelbine revealed high cytotoxicity towards cancer cells. This may reflect a general biological principle of poisonous plants. Highly toxic compounds are not only active towards predators, but also towards plant tissues. Hence, plants need mechanisms to protect themselv…
Challenging Dogma: Thresholds for Genotoxic Carcinogens? The Case of Vinyl Acetate
2002
Although many questions remain unanswered, the general principle of the sequence of events leading to cancer after exposure to genotoxic carcinogens has become increasingly clear. This helps to understand the parameters that influence the shape of the dose-effect curve for carcinogenesis, including metabolic activation and inactivation of carcinogens, DNA repair, cell cycle control, apoptosis, and control by the immune system. A linear dose-response relationship with no observable threshold seems to be a conservative but adequate description for the carcinogenic activity of many genotoxic carcinogens, such as aflatoxin B1, the tobacco-specific nitrosoketone NNK, and probably N,N-diethylnit…
Violence in close relationships and the dramaturgy of violence
2012
The assumption, at the basis of the report, considers the bullying - inside the systemic approach - as a state of oppression caused by the identitary uncertainty of many teenagers. Today, the violence between peers is characterized as one of the most effective strategies for the construction of atypical identity or troubled identities, in specific relational contexts (frames). The mutual acceptance and the permanence in the deviant group, allows the creation/attribution of an identity to each member of the group, and it is subject to the so-called "cognitive responsibility", which allows the voluntary perpetuation (replication) of a "dramatic scene" (framework).This last takes the form of a…
Virtual university–a vehicle for development, cooperation and internationalisation in teaching and learning
2005
The paper discusses the approaches of virtual university strategies and developments in Europe. The discussion is partly based on the work done in the Activity 5 in the EU Thematic Network E4 and partly to the experiences gained through the activities of EUNITE virtual university network of six European universities. Based on our experience we see, that e-learning and virtual university approach can be used for renewal of teaching and learning, both on and off campus. Just three years ago, universities seemed mainly to aim only to develop on campus teaching and learning through ICT. Lately, the use of e-learning as a tool for international cooperation and for virtual mobility (Virtual Erasm…
Topological virtual screening: a way to find new anticonvulsant drugs from chemical diversity.
2003
A topological virtual screening (tvs) test is presented, which is capable of identifying new drug leaders with anticonvulsant activity. Molecular structures of both anticonvulsant-active and non active compounds, extracted from the Merck Index database, were represented using topological indexes. By means of the application of a linear discriminant analysis to both sets of structures, a topological anticonvulsant model (tam) was obtained, which defines a connectivity function. On the basis of this model, 41 new structures with anticonvulsant activity have been identified by a topological virtual screening.
Applying pattern recognition methods plus quantum and physico-chemical molecular descriptors to analyze the anabolic activity of structurally diverse…
2008
The great cost associated with the development of new anabolic-androgenic steroid (AASs) makes necessary the development of computational methods that shorten the drug discovery pipeline. Toward this end, quantum, and physicochemical molecular descriptors, plus linear discriminant analysis (LDA) were used to analyze the anabolic/androgenic activity of structurally diverse steroids and to discover novel AASs, as well as also to give a structural interpretation of their anabolic-androgenic ratio (AAR). The obtained models are able to correctly classify 91.67% (86.27%) of the AASs in the training (test) sets, respectively. The results of predictions on the 10% full-out cross-validation test al…
In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach
2011
In the present study, 21 validated QSAR models that discriminate compounds with high Caco-2 permeability (Papp ≥8×10(-6) cm/s) from those with moderate-poor permeability (Papp <8×10(-6) cm/s) were developed on a novel large dataset of 674 compounds. 20 DRAGON descriptor families were used. The global accuracies of obtained models were ranking between 78-82 %. A general model combining all types of molecular descriptors was developed and it classified correctly 81.56 % and 83.94 % for training and test sets, respectively. An external set of 10 compounds was predicted and 80 % was correctly assessed by in vitro Caco-2 assays. The potential use of the final model was evaluated by a virtual s…
Computational discovery of novel trypanosomicidal drug-like chemicals by using bond-based non-stochastic and stochastic quadratic maps and linear dis…
2009
Herein we present results of a quantitative structure-activity relationship (QSAR) studies to classify and design, in a rational way, new antitrypanosomal compounds by using non-stochastic and stochastic bond-based quadratic indices. A data set of 440 organic chemicals, 143 with antitrypanosomal activity and 297 having other clinical uses, is used to develop QSAR models based on linear discriminant analysis (LDA). Non-stochastic model correctly classifies more than 93% and 95% of chemicals in both training and external prediction groups, respectively. On the other hand, the stochastic model shows an accuracy of about the 87% for both series. As an experiment of virtual lead generation, the …