Search results for "RELATION"
showing 10 items of 10542 documents
Comparing the Capabilities of Mobile Platforms for Business App Development
2015
Businesses increasingly embrace the possibilities of mobile computing. While there is broad advice for app developers in general, development of apps for enterprises is hardly covered. Business apps support internal processes and contribute to customer relationship management. The heterogeneity of platforms for mobile devices makes development difficult. At the same time, companies seek to support several platforms with their apps to maximize customer acceptance and to support the platforms best suited for their employees. Aiming at improving the knowledge on business app development, we present a framework for assessing mobile platforms. For this purpose, we have developed a distinct set o…
Latvian Multiculturalism, Postcolonialism, and World Literature
2020
The aim of this chapter is to discuss the complexity of the self-consciousness of the inhabitants of contemporary Latvia from a postcolonial perspective. This approach demonstrates how the experience of a small nation helps to reveal the common roots of Europe and to build both theoretical and practical bridges between different societies and their members. It also contextualizes the relation of so-called small literatures to the global literary field. The highly acclaimed novel of contemporary Latvian author, Inga Ābele, Klūgu mūks (2014), about the life and work of the Catholic priest and politician Francis Trasuns, provides the focus of attention and serves as the background for a case s…
Gendered Use of the Hedge in Academic Discourse
2013
This paper discusses the distribution of hedges in academic texts in relation to the gender of the writer. The assumption prior to the analysis concerned possible differences in communicative practices between male and female writers reflected in the hedging of their propositions. The textual material covers 20 research articles, 10 written by male and 10 by female authors, published in the Journal of Linguistics in the years 2001–2010. Metadiscourse as “discourse about discourse” is connected with the communicative, social and personal involvement (Hyland 2000). Hedges, as indicators of the writer’s stance, should reveal characteristics of particular writing styles based on powerful or sup…
Structural basis for the potential antitumour activity of DNA-interacting benzo[kl]xanthene lignans
2010
The biological properties and possible pharmacological applications of benzo[kl]xanthene lignans, rare among natural products and synthetic compounds, are almost unexplored. In the present contribution, the possible interaction of six synthetic benzo[kl]xanthene lignans and the natural metabolite rufescidride with DNA has been investigated through a combined STD-NMR and molecular docking approach, paralleled by in vitro biological assays on their antiproliferative activity towards two different cancer cell lines: SW 480 and HepG2. Our data suggest that the benzo[kl]xanthene lignans are suitable lead compounds for the design of DNA selective ligands with potential antitumour properties.
Flavonols and flavan-3-ols as modulators of xanthine oxidase and manganese superoxide dismutase activity.
2014
Experiments were performed to assess the dose-dependent effects of quercetin, kaempferol, (+) catechin, and (-) epicatechin on superoxide radical production through the modulation of manganese superoxide dismutase and xanthine oxidase activities. The experiments were carried out at flavanoid concentrations ranging from 1 µM to 100 µM. This investigation highlighted that flavonols induced opposite effects on superoxide radical production at different doses, i.e. pro-oxidant at the highest concentration (100 µM) and anti-oxidant at the lowest concentration (1 µM). Similar behaviors were observed for xanthine oxidase with flavan-3ols. The diastereoisomer (the catechin) acted as a stronger radi…
Sildenafil protects epithelial cell through the inhibition of xanthine oxidase and the impairment of ROS production
2009
Recent reports suggest that xanthine oxidase (XO), a modified form of the native xanthine dehydrogenase enzyme, plays an important role in various forms of ischemic and vascular injuries, inflammatory diseases, and chronic heart failure. The XO inhibitors allopurinol and its oxidation product oxypurinol held considerable promises in the treatment of these conditions both in experimental animals and in human clinical trials. More recently, an endothelium-based protective effect of sildenafil, a well-known type-5 phosphodiesterase inhibitor, has been reported in preconditioning prior to ischemia/reperfusion in healthy human subjects. Based on the structural similarities between allopurinol an…
Toxicity of fatty acid hydroperoxides towards Yarrowia lipolytica: Implication of their membrane fluidizing action
2007
Abstract Linoleic acid hydroperoxide (HPOD), substrate of hydroperoxide lyase, an enzyme of the lipoxygenase pathway, can be transformed into many aromatic compounds, the so-called “green notes”. The presence of linoleic acid hydroperoxide in the culture medium of Yarrowia lipolytica, the yeast expressing the cloned hydroperoxide lyase of green bell pepper, undoubtedly exerted an inhibition on the growth and a toxic effect with 90% of yeast cells died after 120 min of exposition in 100 mM HPOD solution. The increase in cell membrane fluidity evaluated by measuring fluorescence generalized polarization with the increasing concentration of HPOD in the medium confirmed the fluidizing action of…
Transitions to Working Life: Securing Professional Competence
2014
This chapter examines the transition from education to work as a critical phase of professional career and the development of professional competence Literature on transition to working life has identified several challenges that many graduates meet in the early stages of their career such as: threat of unemployment, inadequate knowledge and skills, decreased self-efficacy and increased stress, instability of professional identity, newcomers’ role and position in a work community, early attrition and changing occupation. The importance of workplace learning in supporting graduates as they transit to the workplace is influential in assisting graduates deal with these challenges. This chapter…
Gender Relations in Postmodern Society: Perceptions and Attitudes of Young Students About Power Relations in Couples
2019
Este artículo presenta resultados de un proyecto que nace de la inquietud de un instituto público de Educación Secundaria Obligatoria (ESO) por conocer cómo son las relaciones de género entre su alumnado. El marco teórico que contribuye a contextualizar los resultados expuestos está centrado en las teorías del poder, del amor y los afectos, y del impacto de las TIC. El objetivo del estudio es diagnosticar cómo se expresan las relaciones de poder en las parejas en centros educativos. De esta manera, se espera poder obtener y plantear elementos que permitan a los centros generar estrategias para la acción futura a partir de los marcos emocionales de las relaciones de poder en las parejas. Con…
Poner el trabajo al servicio de un proyecto de vida : estrategias contra la precariedad
2019
A partir de 20 historias de vida, este artículo se propone presentar las estrategias que algunos jóvenes italianos altamente cualificados han encontrado para eludir la doble amenaza de la precariedad laboral y de la invasión del trabajo en la vida. Centrando sus biografías en un proyecto de innovación social o ligado a la vertiente expresiva del trabajo, los jóvenes investigados se han enfrentado a un destino de explotación, incertidumbre, fragmentación e individualización del itinerario laboral y vital, común a una generación entera. Se ha utilizado la técnica de la entrevista en profundidad. La investigación ha permitido identificar en sus discursos las siguientes estrategias: 1) colocar …