Search results for "RELEASE"
showing 10 items of 602 documents
Biopolymer-Based Hybrid Hydrogels for Biomedical Applications: From Macroscopic to Nanosized Systems
2021
Les partícules portadores basades en biopolímers són biocompatibles i ofereixen la capacitat d’incorporar agents actius hidròfils i hidròfobs. La incorporació d’un fàrmac en una matriu polimèrica pot millorar-ne la protecció contra la degradació en mitjans fisiològics severs. A més, pot controlar-ne l’alliberament al lloc d’acció específic, amb una biodisponibilitat terapèutica augmentada i efectes secundaris o toxicitat minimitzats. Aquesta tesi presenta la preparació de diferents sistemes híbrids de polisacàrids per a encapsular substàncies hidròfiles, que posteriorment són alliberades. Es preparen portadors que varien de mida macroscòpica a nanomètrica mitjançant diferents mètodes: gelif…
Generation of an Eosinophilotactic Factor from Human PMNs by Various Mechanisms of Cell Activation
1979
It is well established that an increase in the number of eosinophils both in tissue and in the circulation is a feature of many clinical conditions based on delayed (1,2) and immediate type hypersensitivity reactions (3,4). Since eosinophils have been recognised to exert specific killer function on parasites (5) and to be prominent participants at sites of inflammation, the mechanisms of their chemo-attraction are of major importance. In immediate type hypersensitivity reactions, eosinophils have been demonstrated to counteract the mediators of inflammation such as histamine (6), the SRS-A (7) and the platelet aggregating factor (8).
Separating efficacy and sedative effects of guanfacine extended release in children and adolescents with ADHD from four randomized, controlled, phase…
2016
IntroductionGuanfacine extended release (GXR) is a non-stimulant treatment for attention-deficit/hyperactivity disorder (ADHD).ObjectiveTo separate efficacy and sedative treatment-emergent adverse events (TEAEs) associated with GXR in four randomized, controlled trials in children (6–12 years) and adolescents (13–17 years) with ADHD.MethodsSPD503-301 (n = 345) and SPD503-304 (n = 324) were 8 and 9 week studies of fixed-dose GXR (≤ 4 mg/day). SPD503-312 (n = 314; adolescents only) and SPD503-316 (n = 338) were 10–13 week studies of dose-optimized GXR (1–7 mg/day).ResultsIn fixed-dose studies, pooled incidences of sedative TEAEs with GXR were highest at week 1 (GXR, 13.9–18.7%; placebo, 8.7%)…
EFFECTS OF DIFFERENT FERTILIZATION LEVELS ON IBERIS SEMPERFLORENS POT CULTURE
2013
The genus Iberis (family Brassicaceae) includes 30 species of annual and perennial herbs and subshrubs that grow in a wide area from western and central Europe to the Mediterranean Basin. IberissemperflorensL. is a perennial evergreen subshrub (30-60 cm high) endemic to southern Italy and Sicily. Due to its abundance of white flowers and extensive flowering period occurring during the winter months, the species has good potential for pot cultivation and outdoor ornamental use in Mediterranean-type climates. Reliable and efficient propagation methods for I. semperflorens nursery production have been determined. However, there are limited information on cultural techniques of this winter flow…
The caramel flavour: impacts of the volatile and the non-volatile fraction on perception
2013
The aim of this thesis was to investigate the impact of the volatile odorant fraction and the non-volatile fraction on the perception of caramel flavour. The first step focused on the analytical characterization of the volatile odorant fraction of caramel using Gas Chromatography coupled to Olfactometry (GC/O), GC/Mass Spectrometry (GC/MS) and heart-cutting MDGC/MS/O. Results highlighted the presence of more than one hundred compounds and demonstrated the complexity of the caramel volatile fraction. The objective of the second step was to understand the contribution of odorant compounds identified to the caramel aroma typicality. Literature shows that odour intensity is not sufficient to ev…
Use of conservative therapy before and after surgery for carpal tunnel syndrome
2021
Abstract Background Conservative therapies are typically offered to individuals who experience mild or intermittent symptoms of carpal tunnel syndrome (CTS) or postoperatively to subjects who have undergone carpal tunnel release. Although long-term studies report mostly positive results for carpal tunnel release, knowledge on the need for conservative treatments following surgery is scarce. The aim of this retrospective cohort study was to examine the use of conservative therapies before and after carpal tunnel releasing surgery. Methods Of 528 patients who underwent carpal tunnel release surgery in the study hospital during the study period, 259 provided sufficiently completed questionnair…
Reliability and Validity of The Finnish Version of The Boston Carpal Tunnel Questionnaire among Surgically Treated Carpal Tunnel Syndrome Patients
2019
Background and Aims: The Boston Carpal Tunnel Questionnaire is the most commonly used outcome measure in the assessment of carpal tunnel syndrome. The purpose of this study was to translate the original Boston Carpal Tunnel Questionnaire into Finnish and validate its psychometric properties. Materials and Methods: We translated and culturally adapted the Boston Carpal Tunnel Questionnaire into Finnish. Subsequently, 193 patients completed the Finnish version of the Boston Carpal Tunnel Questionnaire, 6-Item CTS Symptoms Scale, and EuroQol 5 Dimensions 12 months after carpal tunnel release. The Boston Carpal Tunnel Questionnaire was re-administered after a 2-week interval. We calculated cons…
Dynamics of aroma release during cheese consumption: influence of the physiological state
2014
Studies dealing with food intake usually focus either on in vivo aroma release or on subject physiology and behaviour. However, no approach combining all the parameters is known and the effect of changes in the physiological state (for instance satiation state) has been slightly studied until now. Yet, the evolution of aroma perception during food intake is important because it can modify the consumption behaviour, in particular when the subject is satiated. The objective of this project is to study the dynamics of the evolution of aroma release from model cheese, according to physiological modifications such as satiation attainment. . The present study is a preliminary test led on a small …
Aroma and salt release and perception in model cheeses are explained by salt/fat contents, microstructure, salt mobility and oral processing
2013
The health authorities recommend a reduction in salt (NaCl) and fat contents of foodstuff. Reducing such components without affecting acceptability is a major challenge, particularly because of the interactions with other ingredients such as aroma compounds. This study consisted in a multimodal approach to understand the effect of changes in composition of model cheeses on the mobility and release of flavour molecules (NaCl, aroma compounds), masticatory behaviour and flavour perception. Six flavoured model cheeses have been formulated (three fat/protein contents, two NaCl contents). The rheological properties were analysed using uniaxial compression tests. Microstructure and homogeneity we…
Flavour release and sensory pereption in cheeses
2013
During the eating of food, the in-mouth process leads to food breakdown which induces the release of flavour compounds. Volatile and non-volatile compounds are released into the saliva, and volatile compounds are transferred into the vapour phase to reach olfactory receptors in the nasal cavity. The aim of this chapter is to review the effects of changing the composition of cheeses on the mobility, release and perception of flavour molecules (salt, aroma compounds), and to discuss the results with respect to human physiology. Cheese is a good model because it is possible to vary its composition (in lipids, proteins, salt), in order to comply with nutritional guidelines (less salt, less fat)…