6533b82bfe1ef96bd128d514

RESEARCH PRODUCT

Generation of an Eosinophilotactic Factor from Human PMNs by Various Mechanisms of Cell Activation

H. TeschW. KönigN. Frickhofen

subject

business.industryPlatelet Aggregating FactorEnzyme releaseInflammationMast cellchemistry.chemical_compoundmedicine.anatomical_structurechemistryImmunologyMedicineArachidonic acidmedicine.symptombusinessCell activationHistamineFunction (biology)

description

It is well established that an increase in the number of eosinophils both in tissue and in the circulation is a feature of many clinical conditions based on delayed (1,2) and immediate type hypersensitivity reactions (3,4). Since eosinophils have been recognised to exert specific killer function on parasites (5) and to be prominent participants at sites of inflammation, the mechanisms of their chemo-attraction are of major importance. In immediate type hypersensitivity reactions, eosinophils have been demonstrated to counteract the mediators of inflammation such as histamine (6), the SRS-A (7) and the platelet aggregating factor (8).

yearjournalcountryeditionlanguage
1979-01-01
https://doi.org/10.1007/978-1-4615-9101-6_86