Search results for "RELEVANCE"
showing 10 items of 500 documents
Relevansen av trigonometri : En studie i to deler på relevansen av trigonometri for elever på videregående skole
2017
Masteroppgave matematikkdidaktikk MA502 – Universitetet i Agder 2017 The topic of this master’s thesis is the relevance of mathematics, especially the relevance of trigonometry. Many students ask the question “why do I need to learn about this”. The aim of this study was to give the students an answer to this question. In the research literature, I found that this question has to do with relevance, and that relevance is a connection between people, an activity and future goals. In particular, one needs to question: relevance of what? relevance according to whom? relevance for whom? And relevance to what end? The empirical part of my research consisted of two studies. In Study 1 the purpose …
Global Functional Analyses of Cellular Responses to Pore-Forming Toxins
2011
Here we present the first global functional analysis of cellular responses to pore-forming toxins (PFTs). PFTs are uniquely important bacterial virulence factors, comprising the single largest class of bacterial protein toxins and being important for the pathogenesis in humans of many Gram positive and Gram negative bacteria. Their mode of action is deceptively simple, poking holes in the plasma membrane of cells. The scattered studies to date of PFT-host cell interactions indicate a handful of genes are involved in cellular defenses to PFTs. How many genes are involved in cellular defenses against PFTs and how cellular defenses are coordinated are unknown. To address these questions, we pe…
PED in 2021: a major update of the protein ensemble database for intrinsically disordered proteins
2020
Abstract The Protein Ensemble Database (PED) (https://proteinensemble.org), which holds structural ensembles of intrinsically disordered proteins (IDPs), has been significantly updated and upgraded since its last release in 2016. The new version, PED 4.0, has been completely redesigned and reimplemented with cutting-edge technology and now holds about six times more data (162 versus 24 entries and 242 versus 60 structural ensembles) and a broader representation of state of the art ensemble generation methods than the previous version. The database has a completely renewed graphical interface with an interactive feature viewer for region-based annotations, and provides a series of descriptor…
Outline for a Relevance Theoretical Model of Machine Translation Post-editing
2018
Translation process research (TPR) has advanced in the recent years to a state which allows us to study “in great detail what source and target text units are being processed, at a given point in time, to investigate what steps are involved in this process, what segments are read and aligned and how this whole process is monitored” (Alves 2015, p. 32). We have sophisticated statistical methods and with the powerful tools to produce a better and more detailed understanding of the underlying cognitive processes that are involved in translation. Following Jakobsen (2011), who suspects that we may soon be in a situation which allows us to develop a computational model of human translation, Alve…
Relevance of Tool Life Testing for Tool Replacement Strategies
1986
Several analytical and simulation models have been proposed in order to select the optimal tool replacement strategies both in single and multi-tool machining operations. All of these models, however, assume as known the probability density function that describes the stochastic behaviour of tool life. The costly efforts required in order to achieve an accurate estimate of the p.d.f. limits the use in the shop practice of the above models.
The relationship between debt level and fiscal sustainability in organization for economic cooperation and development countries
2014
In this article we unify the traditional approaches to testing for fiscal sustainability considering the stock-flow system that fiscal variables configure. Our approach encompasses previous ways of testing for sustainability. The results obtained for a group of 17 Organization for Economic Cooperation and Development (OECD) countries point to weak fiscal sustainability, as well as to the existence of cointegration between deficit and debt, confirming the relevance of the stock-flow approach. Allowing for structural breaks and multicointegration turns out to be of critical importance to assess whether the fiscal authorities apply their policies looking for sustainability and whether, simulta…
Economic Growth and Religious Production Efficiency
2005
During the past few years, empirical economic growth modeling has emerged by constructing and testing numerous model and explanatory variable alternatives. One of the most promising recent idea consists that also religious aspects should be included as explanatory variables into economic growth models, therefore capturing influences of culture, moral and ethics. Moral institutions and ethics affect the economic development, as for example, trust and honesty are essential requirements for emerging economic activity. Religious activities and beliefs are documented over a long time period in many Western economies, making quantitative empirical time series data available. Following the idea an…
A human relevance investigation of PPARα-mediated key events in the hepatocarcinogenic mode of action of propaquizafop in rats
2018
Propaquizafop is an herbicide with demonstrated hepatocarcinogenic activity in rodents. A rodent-specific mode of action (MOA) in the liver via activation of peroxisome proliferator-activated receptor α (PPARα) has been postulated based on existing data. Experience with PPARα-inducing pharmaceuticals indicates a lack of human relevance of this MOA. The objective of the present investigation was to evaluate the dependency of early key events leading to liver tumors on PPARα activation in wildtype (WT) compared to PPARα-knockout (KO) rats following 2 weeks exposure to 75, 500 and 1000 ppm propaquizafop in the diet. In WT rats, both WY-14643 (50 mg/kg bw/day) and propaquizafop (dose-dependentl…
Estimating sexual knowledge of people with mild intellectual disability through a valid and reliable assessment scale: The ISK-ID
2021
Background Despite the relevance of assessing sexual knowledge in people with Intellectual Disability, there is a lack of appropriate assessment tools to measure this domain. The current study tests the psychometric properties of the new ‘Inventory of Sexual Knowledge of people with Intellectual Disability’ (ISK-ID). Method 345 individuals with mild intellectual disability completed the ISK-ID before and after the implementation of a sexual education program. Psychometric properties of the ISK-ID were analysed according to Multidimensional Item Response Theory (MIRT). Results Its underlying factorial structure, along with parameters derived from the MIRT (item discrimination, difficulty, an…
Linguistic relevance of duration within the native language determines the accuracy of speech-sound duration processing.
2003
As indexed by electrophysiological measures, in native speakers of a language with linguistically significant opposition between short and long phonemes, the pre-attentive detection accuracy of duration changes in speech sounds was tuned in comparison with that in non-speech sounds. This was not observed in advanced second-language users of the same language, suggesting that second-language acquisition does not lead to speech-specific tuning of the duration processing as does native language acquisition in early childhood.