Search results for "RESISTANCE"
showing 10 items of 3641 documents
Android tool to evaluate grounding resistance
2015
In the absence of sources of rapidly varying field, the study of the potential distribution determined, in a linear medium, by a geometrically complex grounding may be conducted by applying the method of superposition of the effects, known as method of subareas of Maxwell. Such approach can be usefully employed in an educational tool intended for students of electrical engineering.
Il Mare di mezzo: storie di naviganti, di lotta per il diritto e di luci nel buio della frontiera
2022
This paper analyses the way in which, and the reasons why, the Mediterranean Sea, from being a limes between lands, has become the frontier we know today: the space of an emblematic struggle for law and rights, which contrasts the policies of governments with the forced movements of people in migration and with civil society organizations that try to promote and protect fundamental rights. In this context, the direct experience of some search and rescue missions in the Mediterranean Sea has been used to highlight the extent of this conflict with respect to the violation of the national and domestic legal frameworks carried out by the European states, Italy in the lead, also through the invo…
La giuridicità del diritto di resistenza nello Stato costituzional-democratico: una proposta teorica
Il presente lavoro intende indagare i profili di giuridicità del diritto di resistenza come un “diritto giuridico” e una pratica costituzionale giustificabile sul terreno normativo. L’ambito della ricerca è circoscritto agli ordinamenti costituzional-democratici. L’obiettivo finale è mostrare che alcuni casi di “resistenza” dovrebbero essere protetti dalla costituzione ed esentati parzialmente o totalmente dalla punizione prevista per la trasgressione della norma giuridica resistita. È questo il caso di “resistenza costituzionale” e “disobbedienza civile”. Tuttavia, le definizioni di questo tipo di atteggiamenti nei confronti del diritto rimangono generalmente vaghe anche nella letteratura …
Displacement(s) and Identity in the Libyan Story "Al-Malika" by Nağwa Binšatwan
2017
In a context of political repression and social oppression like Libya used to be before the Arab Spring, the literary representation of displacement assumes a central role and sometimes becomes a metaphor of an existential condition. Starting from the analysis of some short stories taken from Al-malika by Nağwa Benshatwan – one of the most interesting voices of Libya’s Contemporary literary landscape – this paper will focus on the concept of displacement interpreted not only as a physical and/or figurative migration but also as a tool for representing personal and collective identity Dans le climat de répression politique et d’oppression sociale qui caractérise la Libye d’avant la “révoluti…
PARADOXICAL EFFECT OF RESISTANCE TRAINING AND HIGH PROTEIN DIET ON PLASMA MYOSTATIN RESPONSE TO EXERCISE
2012
Introduction In recent years, a mounting amount of evidence have suggested that contracting muscle can act as a cytokine producing organ that may influence metabolism (Pedersen 2010). Myostatin (MSTN) relationship with body fat amount, training status and nutrition has been widely investigated but with conflicting results. Although MSTN inhibits the Akt/mTor pathway some studies have shown also an counterintuitive positive correlation between MSTN and muscle mass (myostatin paradox). Moreover MSTN has been shown to reduce IGF-1 stimulated AKT phosphorylation in a dose-dependent manner. We investigated the influence of two months of resistance training (RT) and high protein diet on plasma my…
Diritti, legge e resistenza vs violenza ed anarchia nel pensiero politico liberale di John Locke
2020
In Two Treatises of Government John Locke argues that the political sovereignty belongs to citizens and clarifies the legitimacy of government in terms of natural rights, natural law and social contract. By tracing part of the historiographic debate, I put forth an interpretation that differs from those which since Strauss consider Locke a follower of Hobbes’ political thought or even a masked Hobbesian thinker. From Locke’s standpoint, it is important to tell the legitimate from the illegitimate actions, functions and use of force of institutions. This is a basic point of Locke’s political thought, because the question about the legitimacy of government is connected to the question about t…
Age-related Diseases: Key Role of Insulin Resistance for the Association Between Type II Diabetes and Alzheimer’s Disease
2012
Background: Alzheimer’s disease (AD) and Type 2 diabetes mellitus (T2DM) present many relationships. Insulin resistance (IR) plays a key role in neuronal degeneration and death. Reduced energy makes neurons more sensible to oxidation causing mitochondrial damages. Moreover AD brain has lower insulin utilization, reduced expression of its receptors and of IGF 1 and 2, all necessary for neuronal survival and learning and memory processes. Hyperinsulinemia is correlated with increase of hyerphosphorilated tau-protein. SHIP2, a phosphatase, is an antagonist of PI3K. Since the PI3K plays a key role in the biological effects of insulin, its attenuation could be associated with IR in T2DM. Methods…
Regolazione della longevità in Saccharomyces cerevisiae Ruolo di micro e macronutrienti nella modulazione dell'invecchiamento negli eucarioti
2014
In diversi organismi, dal lievito ai mammiferi, è stato osservato che la riduzione dell'introito calorico aumenta la sopravvivenza e protegge dall'insorgenza di numerose patologie associate all'età. Il meccanismo molecolare tramite cui questo effetto si realizza non è ancora chiaro. Questa ricerca mette in evidenza il ruolo di singoli nutrienti nella sensibilizzazione agli stress e nella promozione dell'invecchiamento, identifica in particolare tre specifici aminoacidi che agiscono da segnalatori pro-aging e descrive le vie molecolari attraverso cui tali molecole agiscono. Poiché i pathway di segnalazione coinvolti nell'invecchiamento e nella risposta ai nutrienti sono significativamente co…
MicroRNAs in Colorectal Cancer Drug Resistance: Shooters become Targets
2013
Copyright: © 2013 Fanale D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. MicroRNAs (MiRNAs) are involved in the regulation of several biological processes such as development, differentiation, metabolism, apoptosis and proliferation. Recently, it has been shown that deregulated expression of miRNAs are present in different human cancers, suggesting a potential role in carcinogenesis [1,2]. Recent evidence suggests that miRNAs may represent potential new therapeutic approaches in patients with dru…
The role of microRNAs in driving EGFR-TKI resistance in NSCLC cell lines
2016
Background: the inhibition of EGFR kinase activity by tyrosine kinase inhibitors (EGFR-TKIs), such as gefitinib and erlotinib, can result in improved response and prolonged progression-free survival (PFS) in NSCLC patients harboring sensitizing exon 19del and exon 21 L858R mutations. Unfortunately, almost all patients will develop resistance to EGFR-TKI, in particular T790M is the most frequent mutation. Nowadays, new methods are urgently needed for a rapid, cost-effective and non-invasive identification of biomarkers as a valuable tool for obtaining the genetic follow-up data during the course of the disease. Circulating microRNAs might represent a new precious biomarker for patients’ moni…