Search results for "RESISTANCE"

Fabrication of a Silicide Thermoelectric Module Employing Fractional Factorial Design Principles

2021

AbstractThermoelectric modules can be used in waste heat harvesting, sensing, and cooling applications. Here, we report on the fabrication and performance of a four-leg module based on abundant silicide materials. While previously optimized Mg2Si0.3Sn0.675Bi0.025 is used as the n-type leg, we employ a fractional factorial design based on the Taguchi methods mapping out a four-dimensional parameter space among Mnx-εMoεSi1.75−δGeδ higher manganese silicide compositions for the p-type material. The module is assembled using a scalable fabrication process, using a Cu metallization layer and a Pb-based soldering paste. The maximum power output density of 53 μW cm–2 is achieved at a hot-side temp…

Évolution du stress gélif et idéotypes de pois d'hiver dans le contexte de changement climatique, à une échelle régionale.

2017

11 pages; International audience; Pea (Pisum sativum L.) is an important crop in temperate regions for its high seed protein concentration that is particularly sensitive to abiotic stresses. The abrupt temperature increase known as the “1987/1988 temperature regime shift” that occurs over Europe is questioning how winter pea will perform in the changing climate. This study assessed the winter frost damage evolution along from 1961 to 2015 in Burgundy-Franche-Comté by using: (1) daily observed and gridded regional temperature data and (2) a validated crop winter frost stress model calibrated for pea. This study shows a global decrease of the frost stress nevertheless resulting from a subtle …

The clinical impact of an extra virgin olive oil enriched mediterranean diet on metabolic syndrome: Lights and shadows of a nutraceutical approach

2022

For years it has been established that the only truly effective treatment of metabolic syndrome (MS) is lifestyle modification to prevent its cardiovascular (e.g., coronary artery disease and atherosclerosis), metabolic (e.g., diabetes mellitus), and hepatic (e.g., steatosis and non-alcoholic steatohepatitis) complications. The focal points of this approach are to increase physical activity and intake of a diet characterized by high quantities of fruits, vegetables, grains, fish, and low-fat dairy products, the so called mediterranean diet (MD); however, the added value of MD is the presence of extra virgin olive oil (EVOO), a healthy food with a high content of monounsaturated fatty acids,…

Multixenobiotic resistance efflux activity in Daphnia magna and Lumbriculus variegatus

2015

Multixenobiotic resistance is a phenomenon in which ATP-binding cassette (ABC) family proteins transfer harmful compounds out of cells. Daphnia magna and Lumbriculus variegatus are model species in aquatic ecotoxicology, but the presence and activity of ABC proteins have not been well described in these species. The aim of this work was to study the presence, activity, and inhibition of ABC transport proteins in D. magna and L. variegatus. The presence of abcb1 and abcc transcripts in 8–9-day-old D. magna was investigated by qRT-PCR. The activity of MXR in D. magna and L. variegatus was explored by influx of the fluorescent ABC protein substrates rhodamine B and calcein-AM, with and without…

Physical disability in community-dwelling older people after hip fracture : randomized controlled trials with physical rehabilitation

2013

V gamma 9V delta 2 T lymphocytes efficiently recognize and kill zoledronate-sensitized, imatinib-sensitive, and imatinib-resistant chronic myelogenou…

2010

Abstract Imatinib mesylate (imatinib), a competitive inhibitor of the BCR-ABL tyrosine kinase, is highly effective against chronic myelogenous leukemia (CML) cells. However, because 20–30% of patients affected by CML display either primary or secondary resistance to imatinib, intentional activation of Vγ9Vδ2 T cells by phosphoantigens or by agents that cause their accumulation within cells, such as zoledronate, may represent a promising strategy for the design of a novel and highly innovative immunotherapy capable to overcome imatinib resistance. In this study, we show that Vγ9Vδ2 T lymphocytes recognize, trogocytose, and efficiently kill imatinib-sensitive and -resistant CML cell lines pre…

Advanced Strategies for Food-Grade Protein Production: A New

2019

Food-grade production of recombinant proteins in Gram-positive bacteria, especially in LAB (i.e., Lactococcus, Lactobacillus, and Streptococcus), is of great interest in the areas of recombinant enzyme production, industrial food fermentation, gene and metabolic engineering, as well as antigen delivery for oral vaccination. Food-grade expression relies on hosts generally considered as safe organisms and on clone selection not dependent on antibiotic markers, which limit the overall DNA manipulation workflow, as it can be carried out only in the expression host and not in E. coli. Moreover, many commercial expression vectors lack useful elements for protein purification. We constructed a “sh…

Midbiotics : conjugative plasmids for genetic engineering of natural gut flora

2019

ABSTRACTThe possibility to modify gut bacterial flora has become an important goal, and various approaches are used to achieve desirable communities. However, the genetic engineering of existing microbes in the gut, which are already compatible with the rest of the community and host immune system, has not received much attention. Here, we discuss and experimentally evaluate the possibility to use modified and mobilizable CRISPR-Cas9-endocing plasmid as a tool to induce changes in bacterial communities. This plasmid system (briefly midbiotic) is delivered from bacterial vector into target bacteria via conjugation. Compared to, for example, bacteriophage-based applications, the benefits of c…

Luoghi comuni. Pratiche di reinvenzione urbana ai Cantieri Culturali della ZIsa

2018

L’8 Dicembre 2011 il Comune di Palermo pubblica un “invito a manifestare interesse” verso i Cantieri Culturali alla Zisa, un luogo che da anni versa in grave stato di abbandono. L’invito, rivolto ad imprenditori individuali, società commerciali o cooperative, operatori economici ed altri soggetti privati interessati alla gestione dei padiglioni che compongono il complesso, trova però un destinatario inatteso. Dieci giorni dopo, infatti, un gruppo di artisti, associazioni e liberi cittadini rispondono all’invito del Comune, indicendo tre giornate di assemblee, incontri, performance, proiezioni e dibattiti che riaprissero quello spazio di mezzo che l’opprimente sinergia fra amministrazione pu…

PENENTUAN KEDALAMAN SUMUR BOR BERDASARKAN DATA GEOLISTRIK RESISTIVITAS DI BEBERAPA KAMPUNG DI KABUPATEN FAK-FAK

2018

Geoelectrical R esistivity method is a geophysical method that can be used to determine subsurface geology based on rock resistivity image. Resistivity survey has been done in some villages, in Fak Fak Regency, West Papua Province. The measurement method that used is sounding, whereas electrode configuration used is Dipole-dipole configuration with a stretch of 100 -150 m. The data obtained are then processed by Progress Res2Dinv. The results of this survey obtained show that in the resistivity sounding measurement point found any good groundwater aquifers, a s the water source of drilled well . Water layer with the thickness between 1-3 m at the surface (alluvial) is a rain water infiltrat…