Search results for "RESISTANCE"

Small things matter : of phages and antibiotic resistance conferring plasmids

2016

Viruses and plasmids are small units of genetic material dependent on cells either transiently or continuously. Intriguingly, stories of these small entities intertwine in antibiotic resistance crisis. Horizontal gene transfer enables bacteria to respond rapidly to chances in their environment. Anthropogenic consumption of antibiotics induces the travel of resistance encoding genes mainly as passengers of conjugative plasmids. In this thesis, I demonstrate that clinically important resistance plasmids could evolutionarily rescue susceptible bacteria under lethal antibiotic concentrations. If mobile resistance genes are available in surrounding community, administration of high doses of anti…

Counteracting the horizontal spread of bacterial antibiotic resistance with conjugative plasmid-dependent bacteriophages

2016

Comparison between different mathematical methods to calcolate insulin resistance in women with polycystic ovary syndrome (PCOS)

2003

France After the Liberation: The Labour Movement, the Employers and the Political Leaders in Their Struggle with the Social Movement

2018

The French defeat in the spring of 1940 and the ensuing German occupation, as well as the establishment of the authoritarian Vichy regime, made it theoretically impossible for social movements to emerge; that is to say, to allow the development of mobilisation(s) and challenge(s) to authority within companies and/or against any aspect of government policy. However, in the summer of 1940 and a fortiori from 1941 onwards, resistance movements were born precisely because of their ability to convey the discontent of the French society and to use its momentum. In this sense, the French Resistance undoubtedly was a social movement, whose members were leading a ‘normal’ life as civilians under occ…

Biopiracy in India: Seed diversity and the scramble for knowledge.

2018

Abstract Background: Biopiracy has usually been discussed mostly in the context of the life sciences, sometimes in dialogue with legal debates or political implications. This paper provides a humanities perspective on contemporary discussions of biopiracy and biopatenting. Hypothesis It proceeds from the hypothesis that contemporary debates and practices of biopiracy can be understood as harking back to colonial legacies, which systematically disregard “native” knowledge or seek to appropriate it for their own purposes. Results Drawing on the work of Vandana Shiva, the present article seeks to redefine the notion of ownership of knowledge from a cultural studies perspective. Exploring the 2…

Physical activity and sense of coherence : a meta-analysis

2020

The salutogenic model of health proposes that sense of coherence, a multi-dimensional construct representing individuals’ perceptions that their environment is comprehensible, manageable, and meaningful, is a key determinant of stress management and well-being. Generalized resistance resources such as preventive health orientation, material resources, and social support are proposed as determinants of sense of coherence. Health behaviors, particularly physical activity, are proposed as indicators of a preventive health orientation and predictors of sense of coherence. We synthesized research on the relationship between physical activity and sense of coherence using three-level meta-analysis…

Binding analysis of Bacillus thuringiensis Cry1 proteins in the sugarcane borer, Diatraea saccharalis (Lepidoptera: Crambidae).

2015

Sugarcane borer (Diatraea saccharalis, F.) is an important corn pest in South America and United States. The aim of the present study was to analyze the susceptibility and binding interactions of three Cry1A proteins and Cry1Fa in a Brazilian D. saccharalis population. The results showed that Cry1Ab was the most active, followed by Cry1Ac, Cry1Fa and Cry1Aa. All Cry1-biotinylated proteins tested bound specifically to the D. saccharalis brush border membrane vesicles (BBMV). Heterologous competition assays showed shared binding sites for all Cry1A proteins and another one shared by Cry1Fa and Cry1Ab. Thus, pyramiding Cry1Aa/Cry1Ac and Cry1F proteins would be a recommended strategy for managi…

Data from: Heat hardening capacity in Drosophila melanogaster is life stage specific and juveniles show the highest plasticity

2019

Variations in stress resistance and adaptive plastic responses during ontogeny have rarely been addressed, despite the possibility that differences between life stages can affect species' range margins and thermal tolerance. Here, we assessed the thermal sensitivity and hardening capacity of Drosophila melanogaster across developmental stages from larval to the adult stage. We observed strong differences between life stages in heat resistance, with adults being most heat resistant followed by puparia, pupae and larvae. The impact of heat hardening (1 h at 35°C) on heat resistance changed during ontogeny, with the highest positive effect of hardening observed in puparia and pupae and the low…

Data from: Conjugation is necessary for a bacterial plasmid to survive under protozoan predation

2016

Horizontal gene transfer by conjugative plasmids plays a critical role in the evolution of antibiotic resistance. Interactions between bacteria and other organisms can affect the persistence and spread of conjugative plasmids. Here we show that protozoan predation increased the persistence and spread of the antibiotic resistance plasmid RP4 in populations of the opportunist bacterial pathogen Serratia marcescens. A conjugation-defective mutant plasmid was unable to survive under predation, suggesting that conjugative transfer is required for plasmid persistence under the realistic condition of predation. These results indicate that multi-trophic interactions can affect the maintenance of co…

Un ecosistema malalt: la lluita contra la resistència a antibiòtics des d’una perspectiva global

2013

La produccio antropogenica d'antibiotics ha provocat una malaltia dels ecosistemes microbians de dimensio planetaria, la repercussio mes immediata de la qual per a l'home es la intractabilitat de les infeccions. La comprensio del fenomen i les possibilitats d'intervencio requereixen nous metodes conceptuals, analitics i tecnologics.