Search results for "RESISTANCE"
showing 10 items of 3641 documents
Endothelial abnormalities in young women with PCOS: correlations with insulin resistance and decreased levels of serum adiponectin
2006
Abstract PURPOSE: Polycystic ovary syndrome (PCOS) is an extremely prevalent disorder in which elevated blood markers of cardiovascular risk and altered endothelial function have been found. This study was designed to determine if abnormal carotid intima-media thickness (IMT) and brachial flow-mediated dilation (FMD) in young women with PCOS may be explained by insulin resistance and elevated adipocytokines. METHODS: A prospective study in 50 young women with PCOS (age: 25.2 +/- 1 years; body mass index [BMI]: 28.7 +/- 0.8) and 50 matched ovulatory controls (age: 25.1 +/- 0.7 years; BMI: 28.5 +/- 0.5) was performed. Carotid IMT, brachial FMD, and blood for fasting glucose, insulin, leptin, …
Conforming to and resisting imposed identities : An autoethnography on academic motherhood
2022
Purpose This research attempts to make sense of the experiences of two academic women who become mothers. Design/methodology/approach This paper is an autoethnography. Applying the autoethnographic method allows us to discuss cultural phenomena through personal reflections and experiences. Our autoethnographic reflections illustrate our struggles and attempts of resistance within discursive spaces where motherhood and our identity as academics intersect. Findings Our personal experiences combined with theoretical elaborations illuminate how the role of the mother continues to be dominated by such gendered discursive practices that conflict with the work role. Once women become mothers, they…
The effect of a temperature-sensitive prophage on the evolution of virulence in an opportunistic bacterial pathogen.
2022
https://doi.org/10.1111/mec.16638 Abstract Viruses are key actors of ecosystems and have major impacts on global biogeochemical cycles. Prophages deserve particular attention as they are ubiquitous in bacterial genomes and can enter a lytic cycle when triggered by environmental conditions. We explored how temperature affects the interactions between prophages and other biological levels by using an opportunistic pathogen, the bacterium Serratia marcescens, that harbours several prophages and that had undergone an evolution experiment under several temperature regimes. We found that the release of one of the prophages was temperature-sensitive and malleable to evolutionary changes. We furthe…
If you can’t be here, be here. Modalit e strategie della protesta online del movimento Black Lives Matter
2021
Eight minutes and forty-six seconds. This is the time in which the murder of George Floyd, in Minnesota, took place on 25 May 2020. A further act of institutionalized violence – granted, legitimized and overlooked by institutions – that made necessary for the Black Lives Matter (BLM) movement to start a series of protests to draw attention to the abuse of power of a racist and corrupt system that highlights the breakdown of the social pact between people in a society. Beyond the ethical and political significance of the event, our contribution aims to reflect on the forms of occupation of the physical and virtual spaces through which BLM constitutes itself as a movement and organizes confli…
Role of hypoxia in pemetrexed-resistance of mesothelioma mediated by proton-coupled folate transporter, and preclinical activity of new anti-LDH comp…
2018
Introduction There are few effective therapies for malignant pleural mesothelioma (MPM), which remains one of the most lethal cancers. We previously demonstrated that low expression of the PCFT transporter, both at mRNA and protein levels, is associated with shorter survival of MPM patients treated with pemetrexed (Giovannetti et al., 2017). Since hypoxia has also been associated to antifolate-resistance (Raz et al, 2014), this study was aimed at elucidating key factors in pemetrexed resistance and hypoxia that may contribute to the rational development of novel therapeutic interventions against mesothelioma. Methods The levels of PCFT and of the hypoxia marker carbonic anhydrase-IX were de…
The Trap of Proximity Violence. Research and Insights into Male Dominance and Female Resistance
2020
This book aims at shifting the emphasis from a general vision of gender-based violence to a more opaque, yet equally destructive one, that related to "proximity violence". The investigative tension of this book aims at bringing to light the crevasses where violence lurks ready to return in disguise as well as the lairs where it hides. Like a whirlwind, violence appears in all its destructive might and disappears. Precisely because violence is of a proxemic kind it is hard to position with respect to those who wish to objectify it. Its screens are many and the causes that feed it are endowed with a good dose of relational and lexical ambiguity. Because it is profoundly unjust, unfair, wrong,…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
The effects of protein and carbohydrate supplementation on body composition and muscle strength during resistance training
2015
Johdanto. Lihavuudesta on tullut maailmanlaajuinen epidemia, ja sen liitännäissairaudet ovat suuri huolenaihe. Voimaharjoittelun ja ravitsemuksen tiedetään muokkaavan tehokkaasti kehon koostumusta. Tämän tutkimuksen tarkoituksena oli selvittää miten proteiini ja hiilihydraatti yhdistettynä voimaharjoitteluun vaikuttavat kehon koostumukseen sekä voimaan. Menetelmät. Tutkimukseen osallistui 78 miestä (ikä 34.7 ± 1.4, pituus 179.9 ± 0.77 cm, paino 83.6 ± 1.4 kg), jotka eivät olleet tottuneet voimaharjoitteluun. Tutkimus sisälsi kokonaisuudessaan 16 viikkoa voimaharjoittelua, joista ensimmäiset neljä viikkoa sisälsivät kaikilla kestovoiman harjoittelua. Tämän perehdyttämisjakson jälkeen koehenk…
Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained
2016
Aerobic exercise, such as running, has positive effects on brain structure and function, such as adult hippocampal neurogenesis (AHN) and learning. Whether high-intensity interval training (HIT), referring to alternating short bouts of very intense anaerobic exercise with recovery periods, or anaerobic resistance training (RT) has similar effects on AHN is unclear. In addition, individual genetic variation in the overall response to physical exercise is likely to play a part in the effects of exercise on AHN but is less well studied. Recently, we developed polygenic rat models that gain differentially for running capacity in response to aerobic treadmill training. Here, we subjected these l…
The effects of whey protein with or without carbohydrates on resistance training adaptations
2015
Background: Nutrition intake in the context of a resistance training (RT) bout may affect body composition and muscle strength. However, the individual and combined effects of whey protein and carbohydrates on long-term resistance training adaptations are poorly understood. Methods: A four-week preparatory RT period was conducted in previously untrained males to standardize the training background of the subjects. Thereafter, the subjects were randomized into three groups: 30 g of whey proteins (n = 22), isocaloric carbohydrates (maltodextrin, n = 21), or protein + carbohydrates (n = 25). Within these groups, the subjects were further randomized into two whole-body 12-week RT regimens aimin…