Search results for "RESISTANCE"

Expert Opinion on Three Phage Therapy Related Topics: Bacterial Phage Resistance, Phage Training and Prophages in Bacterial Production Strain

2018

Phage therapy is increasingly put forward as a “new” potential tool in the fight against antibiotic resistant infections. During the “Centennial Celebration of Bacteriophage Research” conference in Tbilisi, Georgia on 26–29 June 2017, an international group of phage researchers committed to elaborate an expert opinion on three contentious phage therapy related issues that are hampering clinical progress in the field of phage therapy. This paper explores and discusses bacterial phage resistance, phage training and the presence of prophages in bacterial production strains while reviewing relevant research findings and experiences. Our purpose is to inform phage therapy stakeholders such as po…

Resistant ammonia-oxidizing archaea endure, but adapting ammonia-oxidizing bacteria thrive in boreal lake sediments receiving nutrient-rich effluents

2018

Climate change along with anthropogenic activities changes biogeochemical conditions in lake ecosystems, modifying the sediment microbial communities. Wastewater effluents introduce nutrients and organic material but also novel microbes to lake ecosystems, simulating forthcoming increases in catchment loadings. In this work, we first used 16s rRNA gene sequencing to study how the overall sediment microbial community responds to wastewater in six boreal lakes. To examine forthcoming changes in the lake biogeochemistry, we focused on the ammonia-oxidizing archaea (AOA) and bacteria (AOB), and examined their functional and compositional community response to wastewater. Although we found the l…

Silence and Resistance as Experiences and Presentations of Pupil Agency in Finnish Elementary School English Lessons

2014

This paper explores the multitude of ways in which Finnish fifth and sixth grade elementary school pupils experience and present their agency in English lessons, with a special focus on pupils' silence and resistance. Pupil agency is often seen as observable action that is oriented towards institutionally accepted goals and norms. In communicative and constructivist understandings of foreign language learning, learner agency is related to the idea of learning by participating. Participation in the classroom is not only individually but also socially constrained. This article is based on a larger, ecologically oriented ethnographic study on fifth and sixth graders' language learner identitie…

Overcoming resistance to HER2 blockade in breast cancer: AXL as a promising druggable target and prognostic biomarker

2022

Introduction: Breast cancer is a heterogeneous disease consisting of uncontrolled growth of epithelial cells originating in the ducts or breast lobules. It is currently the most diagnosed cancer worldwide and the fifth cause of cancer-related death in general population, but the first cause in women. Breast cancer incidence is higher in developed countries due to increased risk factors and to increased and earlier detection by mammography screening, which considerably reduces mortality. This is the reason why transitioning countries have higher mortality despite having lower incidence. Regarding the origin of the disease, it is evidenced that the pathways implicated in normal development of…

Host-related factors affectingisopod (Asellus aquaticus) susceptibility to and interaction with an acanthocephalan (Acanthocephalus lucii) parasite

2013

Résistance du consommateur : vers une clarification des concepts.

2010

The purpose of this paper is to clarify what is consumer resistance, following a microindividual approach. For this, it uses the linguistic to extract from a set of definitions specific to every disciplinary field the elements of sense that must be the ingredients of a definition relevant to the field of experimental research in consumer behaviour.

Previsione delle prestazioni del veicolo su strada: stato dell’arte

2016

Questo lavoro contiene una rassegna dei metodi che sono usati per la previsione delle prestazioni del veicolo su strada, in dipendenza del motore installato. La prima parte mostra il calcolo delle resistenze al moto, cioè le forze che il veicolo deve vincere per avanzare sulle strade piane e in salita. Particolarmente interessante appare la parte che riguarda la resistenza aerodinamica, della quale si tratta di metodi sperimentali (galleria del vento), metodi empirici e metodi CFD. Si propone inoltre l’applicazione della norma CUNA sulla velocità per la determinazione dei consumi anche al calcolo dei coefficienti aerodinamici. La rassegna esclude la resistenza accidentale in curva perché no…

Rho GTPases: Promising Cellular Targets for Novel Anticancer Drugs

2006

Ras-homologous (Rho) GTPases play a pivotal role in the regulation of numerous cellular functions associated with malignant transformation and metastasis. Rho GTPases are localized at membranes and become activated upon stimulation of cell surface receptors. In their GTP-bound (=active) state, Rho proteins bind to effector proteins, thereby triggering specific cellular responses. Members of the Rho family of small GTPases are key regulators of actin reorganization, cell motility, cell-cell and cell-extracellular matrix (ECM) adhesion as well as of cell cycle progression, gene expression and apoptosis. Each of these functions is of importance for the development and progression of cancer. Fu…

Evaluation of oleander accessions for resistance to Pseudomonas savastanoi pv. nerii

2006

Nine oleander accessions were evaluated for resistance to Pseudomonas savastanoi pv. nerii, causal agent of the oleander knot disease. None of the accessions was resistant when tested with three bacterial strains of different virulence, but they varied significantly in the severity of symptoms induced by these strains. The most susceptible accessions "Dark Salmon" (dark salmon flower) showed deformation of stems, leaves and seed pods and secondary knots on aerial parts, whereas the least susceptible one "White" (white flower), inoculated with the least virulent strain, showed neither localized knots at the inoculation point nor secondary symptoms. In this study an in vitro test, based on pr…

The Role of the Skeletal Muscle Secretome in Mediating Endurance and Resistance Training Adaptations

2021

Exercise, in the form of endurance or resistance training, leads to specific molecular and cellular adaptions not only in skeletal muscles, but also in many other organs such as the brain, liver, fat or bone. In addition to direct effects of exercise on these organs, the production and release of a plethora of different signaling molecules from skeletal muscle are a centerpiece of systemic plasticity. Most studies have so far focused on the regulation and function of such myokines in acute exercise bouts. In contrast, the secretome of long-term training adaptation remains less well understood, and the contribution of non-myokine factors, including metabolites, enzymes, microRNAs or mitochon…