Search results for "RICH"

Values, valuations, and axiological norms in Richard Rorty's neopragmatism: studies, polemics, interpretations

2015

B subunits of cholera toxin and thermolabile enterotoxin of Escherichia coli have similar adjuvant effect as whole molecules on rotavirus 2/6-VLP spe…

2015

The purpose of this study was to evaluate the adjuvant effect of the B subunits of cholera toxin (CT) and the thermolabile enterotoxin of Escherichia coli (LT) by the intrarectal route of immunization and compare them to the whole molecules CT and LT-R192G, a non toxic mutant of LT, using 2/6-VLP as an antigen, in mice. All molecules induced similar antigen specific antibody titers in serum and feces, whereas different T cell profiles were observed. CTB and LTB, conversely to CT and LT-R192G, did not induce detectable production of IL-2 by antigen specific T cells. Moreover, CTB, conversely to LT-R192G, CT and LTB, did not induce antigen specific CD4+CD25+Foxp3- and Foxp3+ T cells, thus sho…

Different profile and distribution of antigen specific T cells induced by intranasal and intrarectal immunization with rotavirus 2/6-VLP with and wit…

2013

International audience; In this study, we compared both the profile and distribution of antigen specific primed T cells after intrarectal (IR) and intranasal (IN) immunization with rotavirus (RV) 2/6-VLP, alone or in the presence of LT-R192G, in order to highlight the differences between the two routes and the impact of the adjuvant. Adult BALB/c mice were immunized once with 2/6-VLP with or without adjuvant and the T cell response was analyzed in lymphoid tissues after in vitro restimulation with the antigen. IN, but not IR, immunization of mice with 2/6-VLP alone induced antigen-specific IL-10 and IL-17 secreting T cells. IL-10-, in contrast to IL-17-, secreting T cells did not migrate to…

Substanssi dualismi v. filosofinen behaviorismi

2017

Tämän tutkimuksen tarkoituksena on tarkastella tanskalaisen filosofin Erich Klawonnin argumentteja minä-substanssin puolesta ja englantilaisen filosofin Gilbert Rylen kritiikkiä kartesiolaiselle dualismille. Klawonn argumentoi, että ruumis ja mieli ovat kaksi erillistä substanssia, fyysinen ja aineeton minä-substanssi. Hänelle minä-substanssi edustaa sellaista, jolla on kattavat piirteet. Näitä piirteitä ovat mentaalisuus, yksilöllistäminen, ajan vaikuttamattomuus ja kuolemasta selviytyminen. Gilbert Rylen argumentit edustavat kriittistä näkemystä kartesiolaiselle dualismille. Hänen pohtii, ettei ole mitään aavemaista entiteettiä, joka hallitsisi ruumista. Näin ollen, ”aave koneessa dogmi” …

Verwaltungs-Bericht der Rigaschen Stadt-Cassa für das Jahr 1867

1868

Dopamine antagonists impair ‘red-green’ discrimination in goldfish after intravitreal injection

1995

Color vision in goldfish is tetrachromatic. However, under mesopic illumination conditions the L-cones do not contribute to wavelength discrimination, and color vision becomes trichromatic. To investigate the role of dopamine in light adaptation, we tested the effect of the unspecific dopamine antagonist haloperidol and of the specific dopamine Dl receptor antagonists SCH 23390 and SKF 83566-biotinyl in behavioral wavelength discrimination experiments. After injection of dopamine antagonists into the vitreous, a reduction in wavelength discrimination was observed in the range between 560 nm and 630 nm but not in the range between 404 nm and 501 nm.

Synergistic effects of childhood adversity and polygenic risk in first-episode psychosis

2023

The European Network of National Schizophrenia Networks Studying Gene-Environment Interactions (EU-GEI) Project is funded by grant agreement HEALTH-F2-2010-241909 (Project EU-GEI) from the European Community’s Seventh Framework Programme.

Rapid evolutionary adaptation to elevated salt concentrations in pathogenic freshwater bacteria Serratia marcescens.

2014

Rapid evolutionary adaptions to new and previously detrimental environmental conditions can increase the risk of invasion by novel pathogens. We tested this hypothesis with a 133-day-long evolutionary experiment studying the evolution of the pathogenic Serratia marcescens bacterium at salinity niche boundary and in fluctuating conditions. We found that S. marcescens evolved at harsh (80 g/L) and extreme (100 g/L) salt conditions had clearly improved salt tolerance than those evolved in the other three treatments (ancestral conditions, nonsaline conditions, and fluctuating salt conditions). Evolutionary theories suggest that fastest evolutionary changes could be observed in intermediate sele…

Effects of the introduction of a biocontrol strain of Trichoderma atroviride on non target soil micro-organisms

2009

International audience; The main objective of this study was to assess the impact of the application of an antagonistic strain of Trichoderma atroviride on the native microbial soil communities. The structures of the fungal and bacterial communities were assessed by T-RFLP (terminal restriction fragment length polymorphism) method, based on T-RFLP analysis of 18S and 16S rRNA genes, respectively. Results showed that the introduction of the strain I-1237 into two soils slightly modified the microbial diversity, only for a short period of time. Nine months post-inoculation resilience took place, resulting in similar structures of the fungal and bacterial communities in the inoculated and cont…

Tristetraprolin regulation of interleukin-22 production

2015

AbstractInterleukin (IL)-22 is a STAT3-activating cytokine displaying characteristic AU-rich elements (ARE) in the 3′-untranslated region (3′-UTR) of its mRNA. This architecture suggests gene regulation by modulation of mRNA stability. Since related cytokines undergo post-transcriptional regulation by ARE-binding tristetraprolin (TTP), the role of this destabilizing protein in IL-22 production was investigated. Herein, we demonstrate that TTP-deficient mice display augmented serum IL-22. Likewise, IL-22 mRNA was enhanced in TTP-deficient splenocytes and isolated primary T cells. A pivotal role for TTP is underscored by an extended IL-22 mRNA half-life detectable in TTP-deficient T cells. Lu…