Search results for "RIG"

p73 deficiency results in impaired self renewal and premature neuronal differentiation of mouse neural progenitors independently of p53

2010

10 p.-5 fig.

Design, Synthesis, Chemical and Biochemical Insights Into Novel Hybrid Spirooxindole-Based p53-MDM2 Inhibitors With Potential Bcl2 Signaling Attenuat…

2021

The tumor resistance to p53 activators posed a clinical challenge. Combination studies disclosed that concomitant administration of Bcl2 inhibitors can sensitize the tumor cells and induce apoptosis. In this study, we utilized a rapid synthetic route to synthesize two novel hybrid spirooxindole-based p53-MDM2 inhibitors endowed with Bcl2 signaling attenuation. The adducts mimic the thematic features of the chemically stable potent spiro [3H-indole-3,2′-pyrrolidin]-2(1H)-ones p53-MDM2 inhibitors, while installing a pyrrole ring via a carbonyl spacer inspired by the natural marine or synthetic products that efficiently inhibit Bcl2 family functions. A chemical insight into the two synthesized…

A “Painful Tic Convulsif” (Trigeminal Neuralgia And Ipsilateral Facial Spasm) Due To Double Neuro-Vascular Impingement: A Case Report.

2011

Neurophysiological Changes After Paired Brain and Spinal Cord Stimulation Coupled With Locomotor Training in Human Spinal Cord Injury

2021

Neurophysiological changes that involve activity-dependent neuroplasticity mechanisms via repeated stimulation and locomotor training are not commonly employed in research even though combination of interventions is a common clinical practice. In this randomized clinical trial, we established neurophysiological changes when transcranial magnetic stimulation (TMS) of the motor cortex was paired with transcutaneous thoracolumbar spinal (transspinal) stimulation in human spinal cord injury (SCI) delivered during locomotor training. We hypothesized that TMS delivered before transspinal (TMS-transspinal) stimulation promotes functional reorganization of spinal networks during stepping. In this p…

Minor Losses and Best Manifold Position in the Optimal Design of Paired Sloped Drip Laterals

2018

Arranging paired laterals so that two distribution pipes extend in opposite directions from a common manifold contributes to providing more uniform pressure to all laterals in the system, increasing water use and energy efficiency of micro-irrigation. Towards this end, by neglecting emitters’ minor losses, analytical procedures to design paired drip laterals laid on uniform slopes were introduced. More recently, it was shown that for an optimal paired sloped lateral design the best position of the manifold (BMP) equals 24%. In this paper, first the mentioned analytical procedure is extended to the case in which minor losses are considered. Second, by neglecting minor losses, a comparison in…

"Per comodo dell'alloggio et ornamento della Casa", Girolamo Frigimelica Roberti e l'ampliamento del palazzo Pisani a Santo Stefano: 1711-1720.

2012

Economics of wage premia and wage rigidity

2017

The focus of this dissertation is on the effects of specific employer characteristics on wages and wage rigidity and how these characteristics enter the wage-setting process. The dissertation includes an introductory chapter and five separate essays. The introduction provides motivation, background on the main keywords and an overview of the thesis. Chapters two and three study how internal references affect wages and wage rigidity from a theoretical perspective. The fourth chapter estimates the effect of firm size on wages in the Finnish labor market. Chapter five develops on the preceding and analyses how profit sharing schemes affect the firm size premium. Chapter six studies how interna…

COVID-SCORE Spain: public perceptions of key government COVID-19 control measures

2021

Abstract Background Spain was initially one of the countries most affected by the coronavirus disease 2019 (COVID-19) pandemic. In June 2020, the COVID-SCORE-10 study reported that the Spanish public’s perception of their government’s response to the pandemic was low. This study examines these perceptions in greater detail. Methods We employed an ordered logistic regression analysis using COVID-SCORE-10 data to examine the Spanish public’s perception of 10 key aspects of their government’s COVID-19 control measures. These included support for daily needs, mental and general health services, communication, information and coordination, which were examined by gender, age, education level, hav…

Papīra locīšanas prasmju apguves veicināšanas iespējas sešgadīgiem bērniem

2019

Darba autors ir Iveta Bankova. Darba temats ir papīra locīšanas prasmju apguves veicināšanas iespējas sešgadīgiem bērniem. Pētījuma mērķis ir teorētiski analizēt un atklāt sešgadīgu bērnu papīru locīšanas prasmju apguves iespējas pirmsskolas izglītības iestādē. Hipotēze: locīšanas prasmes bērni apgūst vislabāk, ja: •tiek ņemts vērā bērna intereses un vajadzības; • mācību procesā izmanto didaktikas principus no vieglākā uz sarežģīto. Pirmajā nodaļā tiek analizēts prasmju jēdziens dažādu autoru I.Žogles, A.Karules, N.Poddjakovas, V.Hibneres, L.Grasmanes, V.Avotiņa skatījumā. Skaidrots prasmju jēdziens pirmsskolas mācību kontekstā. Otrajā nodaļā izzināta un analizēta psihologu V.Renģes, L.Grīn…

Experimental evolution of an RNA virus in cells with innate immunity defects

2015

Experimental evolution studies have shown that RNA viruses respond rapidly to directional selection and thus can adapt efficiently to changes in host cell tropism, antiviral drugs, or other imposed selective pressures. However, the evolution of RNA viruses under relaxed selection has been less extensively explored. Here, we evolved vesicular stomatitis virus in mouse embryonic fibroblasts knocked-out for PKR, a protein with a central role in antiviral innate immunity. Vesicular stomatitis virus adapted to PKR-negative mouse embryonic fibroblasts in a gene-specific manner, since the evolved viruses exhibited little or no fitness improvement in PKR-positive cells. Full-length sequencing revea…