Search results for "RIG"
showing 10 items of 9548 documents
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Synergy of Sentinel-1 and Sentinel-2 Time Series for Cloud-Free Vegetation Water Content Mapping with Multi-Output Gaussian Processes
2023
Optical Earth Observation is often limited by weather conditions such as cloudiness. Radar sensors have the potential to overcome these limitations, however, due to the complex radar-surface interaction, the retrieving of crop biophysical variables using this technology remains an open challenge. Aiming to simultaneously benefit from the optical domain background and the all-weather imagery provided by radar systems, we propose a data fusion approach focused on the cross-correlation between radar and optical data streams. To do so, we analyzed several multiple-output Gaussian processes (MOGP) models and their ability to fuse efficiently Sentinel-1 (S1) Radar Vegetation Index (RVI) and Senti…
Siniristi ja superlatiivi : Suomi-Ruotsi -yleisurheilumaaottelujen radioselostukset kansallisen identiteetin tuottajina 1959-1999
2000
Factores radiológicos predictivos de accesibilidad quirúrgica a la fosa pterigopalatina
2020
La fosa pterigopalatina es una pequeña región anatómica con forma de pirámide invertida, localizada a caballo entre la base del cráneo y el macizo facial. Es un espacio pequeño y estrecho, estructuralmente complicado y de difícil accesibilidad quirúrgica. En la fosa se aloja el ganglio esfenopalatino, que está implicado en una amplia variedad de enfermedades relacionadas con el dolor facial de origen neurovegetativo, como la cefalea en racimos. La reciente aparición de técnicas basadas en la neuromodulación del ganglio esfenopalatino para el tratamiento de cefaleas en racimo refractarias hace imprescindible profundizar en el conocimiento de la fosa pterigopalatina y de sus vías de acceso. E…
DEM-resolution control on rainfall-triggered landslide modeling within a triangulated network-based model
2019
Catchment slope distribution significantly controls rainfall-triggered landslide modeling, in both direct and indirect ways. Slope directly determines the soil volume associated with instability. Indirectly, it affects the subsurface lateral redistribution of soil moisture across the basin, which in turn determines the water pore pressure conditions that impact slope stability. It is thus clear that the accuracy in reproducing slope distribution may be crucial in slope stability analysis. The resolution of the Digital Elevation Model (DEM) regulates the description of the topography. The correlation between raster resolution and landslide model outputs has been investigated in the literatur…
Rédiger pour être publié ! 2e édition 2012
2012
Publish or perish. This saying clearly exemplifies that science communication is vital for scientists, research bodies and nation competitiveness. Nowadays both computers and internet have deeply changed the way scientific articles are written and published. In an editorial world moving at accelerated pace, scientists are eager to get their papers published in the best journals because impact factors are ruling careers and funding. Since fundings are provided by various public and private bodies, scientific papers should be partly understandable by a wide audience from journalists to entrepreneurs, political leaders and the general public. However, as an editor of scientific journals, I obs…
Medial Gastrocnemius Muscle Architecture Is Altered After Exhaustive Stretch-Shortening Cycle Exercise
2019
Muscle architecture is an important component of muscle function, and recent studies have shown changes in muscle architecture with fatigue. The stretch-shortening cycle is a natural way to study human locomotion, but little is known about how muscle architecture is affected by this type of exercise. This study investigated potential changes in medial gastrocnemius (MG) muscle architecture after exhaustive stretch-shortening cycle exercise. Male athletes (n = 10) performed maximal voluntary contractions (MVC) and maximal drop jump (DJ) tests before and after an exercise task consisting of 100 maximal DJs followed by successive rebound jumping to 70% of the initial maximal height. The exerci…
Enterobacter cloacae administration induces hepatic damage and subcutaneous fat accumulation in high-fat diet fed mice.
2018
Accumulating evidence indicates that gut microbiota plays a significant role in obesity, insulin resistance and associated liver disorders. Family Enterobacteriaceae and especially Enterobacter cloacae strain B29 have been previously linked to obesity and hepatic damage. The underlying mechanisms, however, remain unclear. Therefore, we comprehensively examined the effects of E. cloacae subsp. cloacae (ATCC® 13047™) administration on host metabolism of mice fed with high-fat diet (HFD). C57BL/6N mice were randomly divided into HFD control, chow control, and E. cloacae treatment groups. The E. cloacae treatment group received live bacterial cells in PBS intragastrically twice a week, every ot…
Ravinnon vaikutus happo-emästasapainoon ja rasva-aineenvaihduntaan levossa sekä kestävyyskuormituksessa eri-ikäisillä miehillä ja naisilla
2012
Johdanto. On todettu, että ruokavaliolla voidaan vaikuttaa elimistön happo-emästasapainoon. Elimistön happamuus on yhteydessä fyysiseen suorituskykyyn, mutta lisäksi mm. diabeteksen, sepelvaltimotaudin, keskivartalolihavuuden ja syöpien riskiin. pH:n lasku eli happamuuden lisääntyminen heikentää lihasten voimantuottokykyä ja välittömän energianlähteen adenosiinitrifosfaatin (ATP) muodostumista ja käyttöä. Kasvispitoisen ruokavalion on todettu nostavan virtsan pH:ta ja lisäksi laskevan veren kokonaiskolesteroli- sekä LDL (low density lipoprotein) -kolesterolin pitoisuuksia. Tutkimuksen tarkoitus. Tämän tutkimuksen tarkoituksena oli selvittää normaaliproteiinisen kasvisravinnon (EMÄS, PRAL 0)…
Adaptation to fluctuations in temperature by nine species of bacteria.
2017
Abstract Rapid environmental fluctuations are ubiquitous in the wild, yet majority of experimental studies mostly consider effects of slow fluctuations on organism. To test the evolutionary consequences of fast fluctuations, we conducted nine independent experimental evolution experiments with bacteria. Experimental conditions were same for all species, and we allowed them to evolve either in fluctuating temperature alternating rapidly between 20°C and 40°C or at constant 30°C temperature. After experimental evolution, we tested the performance of the clones in both rapid fluctuation and in constant environments (20°C, 30°C and 40°C). Results from experiments on these nine species were comb…