Search results for "RIMI"
showing 10 items of 3981 documents
I traffici illeciti nell’area del Mediterraneo. Prevenzione e repressione nel diritto interno, europeo ed internazionale
2018
Il testo presenta il tema dei traffici illeciti nel Mediterraneo, oggetto del VIII Corso “Giuliano Vassalli” per dottorandi, svoltosi a Noto nel 2017, anche in relazione ai contributi dei partecipanti ai lavori, una selezione dei quali è stata pubblicata sulla stessa rivista The text presents the topics of the illicit traffics in the Mediterranean area, which was the subject of the 8th Training Course "Giuliano Vassalli" for PhD Candidates, held in Noto in 2017. The remarks are complemented by references to the contributions of the participants selected for the pubblication in the same review.
Combining near-infrared illuminants to optimize venous imaging
2007
The first and perhaps most important phase of a surgical procedure is the insertion of an intravenous (IV) catheter. Currently, this is performed manually by trained personnel. In some visions of future operating rooms, however, this process is to be replaced by an automated system. We previously presented work for localizing near-surface veins via near-infrared (NIR) imaging in combination with structured light ranging for surface mapping and robotic guidance. In this paper, we describe experiments to determine the best NIR wavelengths to optimize vein contrast for physiological differences such as skin tone and/or the presence of hair on the arm or wrist surface. For illumination, we empl…
El derecho penal de la imigración en Italia: un ejemplo de derecho penal del medio (Immigration Criminal Law in Italy: an example of the Criminal Law…
2015
Immigration Criminal Law should be more appropriately called “Criminal Law of the Irregular Immigrant”, since it shows to essentially be based on the criminalization of mere subjective “status”, rather than offensive managements of legal goods. Indeed, behind the protective shelter of an apparent balance between the need to legally protect human rights and the interest in controlling the migratory flow, the system of incriminations in this sector seems to be deeply imbalanced towards the punishment of types of perpetrators who are socially dangerous. It is namely a matter of model of criminal law very similar to the well known standard of “ Criminal Law of the Enemy”. The inspiring “ratio” …
Immigrati e diritti sociali: parità di trattamento e tutela multilivello
2017
Il saggio analizza la tutela antidiscriminatoria di cui godono i lavoratori immigrati all'insegna di una prospettiva multilivello: più in particolare viene descritto il complesso di strumenti normativi del diritto nazionale ed europeo a tutela delle situazioni giuridiche soggettive degli immigrati (ad es., in materia di sicurezza sociale), per come interpretato dalla Corte Costituzionale, dalla Corte di Giustizia e dalla Corte EDU. Da ultimo, vengono analizzati i recenti orientamenti giurisprudenziali, che oscillano tra l'affievolimento del principio paritario in ragione di sempre più stringenti vincoli di bilancio, e la tendenziale parificazione tra cives e non cives alla luce del principi…
I reati culturalmente orientati. Cultura dell'altro e diritto penale.
2012
Il contributo esamina le peculiari caratteristiche dei reati culturalmente orientati. Dopo aver esaminato i principali modelli politici di regolamentazione della diversità culturale, l'Autore si interroga su quali possano essere gli strumenti giuridici più adeguati per garantire, da un lato, il rispetto dell'identità culturale del reo e, dall'altro, i diritti fondamentali della vittima.
Interferon-α Abrogates Tolerance Induction by Human Tolerogenic Dendritic Cells
2011
Background Administration of interferon-α (IFN-α) represents an approved adjuvant therapy as reported for malignancies like melanoma and several viral infections. In malignant diseases, tolerance processes are critically involved in tumor progression. In this study, the effect of IFN-α on tolerance induction by human tolerogenic dendritic cells (DC) was analyzed. We focussed on tolerogenic IL-10-modulated DC (IL-10 DC) that are known to induce anergic regulatory T cells (iTregs). Methodology/Principal Findings IFN-α promoted an enhanced maturation of IL-10 DC as demonstrated by upregulation of the differentiation marker CD83 as well as costimulatory molecules. IFN-α treatment resulted in an…
2004
Autoimmune inflammation, such as in rheumatoid arthritis, is characterized by activated Th1 cells without sufficient Th2 differentiation that might downmodulate the chronic immune response. Delineation of the mechanisms that control T-cell differentiation is therefore of major importance for the understanding of the pathogenesis of autoimmune diseases. The transcription factor GATA-3 has been implicated in regulating Th2 cell differentiation in murine T cells in vitro, but its role in vivo and, in particular, in human T-cell differentiation is currently unknown. To dissect the role of GATA-3 in human T-cell differentiation and T-cell-mediated effector functions, we used the unique opportuni…
Monoclonal antibody-based immunoassays for cyprodinil residue analysis in QuEChERS-based fruit extracts
2015
Cyprodinil is among the most common agrochemical residues found in highly perishable fruits, such as strawberries. In the present study, high-affinity monoclonal antibodies to this anilinopyrimidine fungicide were raised for the first time with the aim to produce valuable immunochemical analytical assays. Cyprodinil bioconjugates and the generated novel monoclonal antibodies were employed for sensitive competitive immunoassay development in two different formats. The limits of detection of the optimized assays were 20 and 30 ng L-1 for the indirect and direct assay, respectively. Influence over assay parameters of different physicochemical factors was studied. Strawberry samples were extrac…
Inhibition of Transfer to Secondary Receptors by Heparan Sulfate-Binding Drug or Antibody Induces Noninfectious Uptake of Human Papillomavirus
2007
ABSTRACT Infection with various human papillomaviruses (HPVs) induces cervical cancers. Cell surface heparan sulfates (HS) have been shown to serve as primary attachment receptors, and molecules with structural similarity to cell surface HS, like heparin, function as competitive inhibitors of HPV infection. Here we demonstrate that the N , N ′-bisheteryl derivative of dispirotripiperazine, DSTP27, efficiently blocks papillomavirus infection by binding to HS moieties, with 50% inhibitory doses of up to 0.4 μg/ml. In contrast to short-term inhibitory effects of heparin, pretreatment of cells with DSTP27 significantly reduced HPV infection for more than 30 h. Using DSTP27 and heparinase, we fu…
Mast Cells Are Key Promoters of Contact Allergy that Mediate the Adjuvant Effects of Haptens
2011
SummaryA prominent feature of sensitizing environmental compounds that cause allergic contact dermatitis is the rapid induction of an innate inflammatory response that seems to provide danger signals for efficient T cell priming. We generated mouse models of mast cell deficiency, mast cell-specific gene inactivation, and mast cell reporter mice for intravital imaging and showed that these adjuvant effects of contact allergens are mediated by mast cells and histamine. Mast cell deficiency resulted in impaired emigration of skin DCs to the lymph node and contact hypersensitivity was dramatically reduced in the absence of mast cells. In addition, mast cell-specific inactivation of the Il10 gen…