Search results for "RIMI"
showing 10 items of 3981 documents
Automated Determination of Trimipramine and N-Desmethyl-Trimipramine in Human Plasma or Serum by HPLC With On-Line Solid Phase Extraction
1995
A fully automated method including column-switching and isocratic high performance liquid chromatography (HPLC) was developed for determination of the tricyclic antidepressant trimipramine (T) and its N-demethylated metabolite N-desmethyltrimipramine (DT). The limit of quantification was below 10 ng/ml for T and DT. The assay revealed linearity between detector response and drug concentration in a therapeutically relevant range of 10 to 500 ng/ml. The mean intra- and interassay variabilities were 6.2 and 12.3%, respectively, for T and 4.7 and 8.7% respectively, for DT. The method can be applied to therapeutic drug monitoring of patients under T therapy and may be useful for pharmacokinetic …
Quantitative analysis of six pesticides in fruits by capillary electrophoresis-electrospray-mass spectrometry.
2005
A method to identify and quantify six pesticide residues - dinoseb, pirimicarb, procymidone, pyrifenox, pyrimethanil, and thiabendazole - in peaches and nectarines using capillary electrophoresis-electrospray ionization-quadrupole ion trap-tandem mass spectrometry (CE-ESI-MS/MS) is described. Separation was carried out using a buffer of 0.3 M ammonium acetate at pH 4 with 10% methanol. Pesticide residues present in peach and nectarine samples were preconcentrated by solid-phase extraction using C(18), eluted with CH(2)Cl(2), concentrated to dryness, and redissolved in buffer to obtain lower detection limits. The recoveries of the analytes ranged from 58 to 99% and the relative standard devi…
Valutare la devianza costruttiva nei contesti di lavoro
2017
Il presente lavoro fornisce un contributo al tema della devianza organizzativa costruttiva, intesa come un insieme di comportamenti volontari di violazione delle norme organizzative e delle procedure di lavoro, con l’intento di rispondere efficacemente ai problemi organizzativi e finalizzati a conseguire una buona performance. Attraverso due studi indipendenti è stato proposto un adattamento italiano della scala di devianza organizzativa costruttiva (Galperin, 2012), che ha mostrato, tramite analisi esplorative e confermative, soddisfacenti risultati dal punto di vista psicometrico e della validità convergente e discriminante. Sono emerse inoltre le relazioni positive del costrutto con il p…
La teoria dell’associazione-rinforzo differenziale di Robert L. Burgess e Ronald L. Akers
2017
Il saggio analizza gli sviluppi compiuti da Robert L. Burgess e Ronald L. Akers dell’associazione differenziale a partire dagli approcci psicologici dell’apprendimento maturati in ambito comportamentista.
Dalle teorie del labeling alla costruzione dei problemi sociali
2017
Il saggio analizza gli studi sulla devianza e sul crimine di derivazione interazionista chiamati in vario modo: «teoria» dell’etichettamento o labelling theory o anche «prospettiva interazionista della devianza», «teoria della reazione sociale» o «nuova teoria della devianza». Si tiene conto di approcci e applicazioni diversificate accomunati dall'analisi della reazione sociale alle condotte devianti e criminali e nei confronti dei processi di definizione «che li costruiscono» e li «costituiscono».
3D and multispectral imaging for subcutaneous veins detection.
2009
The first and perhaps most important phase of a surgical procedure is the insertion of an intravenous (IV) catheter. Currently, this is performed manually by trained personnel. In some visions of future operating rooms, however, this process is to be replaced by an automated system. Experiments to determine the best NIR wavelengths to optimize vein contrast for physiological differences such as skin tone and/or the presence of hair on the arm or wrist surface are presented. For illumination our system is composed of a mercury arc lamp coupled to a 10nm band-pass spectrometer. A structured lighting system is also coupled to our multispectral system in order to provide 3D information of the p…
Atom- and Bond-Based 2D TOMOCOMD-CARDD Approach and Ligand-Based Virtual Screening for the Drug Discovery of New Tyrosinase Inhibitors
2008
Two-dimensional atom- and bond-based TOMOCOMD-CARDD descriptors and linear discriminant analysis (LDA) are used in this report to perform a quantitative structure-activity relationship (QSAR) study of tyrosinase-inhibitory activity. A database of inhibitors of the enzyme is collected for this study, within 246 highly dissimilar molecules presenting antityrosinase activity. In total, 7 discriminant functions are obtained by using the whole set of atom- and bond-based 2D indices. All the LDA-based QSAR models show accuracies above 90% in the training set and values of the Matthews correlation coefficient (C) varying from 0.85 to 0.90. The external validation set shows globally good classifica…
Bibliotecas abiertas. El programa de visitas de la Biblioteca Valenciana Nicolau Primitiu. Información bibliográfica y difusión bibliotecaria. Biblio…
2022
En un contexto de reducción de la financiación pública y de cambio de paradigma en el acceso a la información, la supervivencia de las bibliotecas está ligada a un mayor y mejor conocimiento de la ciudadanía de sus colecciones, productos y servicios. En este estudio se analiza el programa de visitas de la Biblioteca Valenciana Nicolau Primitiu, sus características, destinatarios y tipologías, así como los resultados alcanzados hasta ahora. In a context of reduced public funding and a paradigm shift in access to information, the survival of libraries is linked to greater and better knowledge by citizens of their collections, products, and services. This study analyzes the visits program of t…
Human Dignity and Legally Protected Goods in Criminal Law
2020
Criminal law protects certain basic goods because they are directly or indirectly connected with the dignity of the person. However, in cases such as euthanasia, prostitution or surrogacy motherhood, the appeal to the dignity of the person is used, in the opposite sense, as the basis for decriminalization. In these cases, dignity is identified with the autonomy of the person and their capacity to dispose of all their goods, even if they are essential. This work argues that there is an ontological core of dignity (requirement of absolute respect) that is subtracted from autonomy and that is protected by the concept of ‘moral integrity’. It prevents certain conducts from being decriminalized …
Criminal systematic and limits of Proposals Functionalists ( Weightings About Warranties , Citizenship and Human Rights )
2016
Make a critique of functionalism means looking at the history of the construction of the penal systems. It is observed that the rigor of analysis is something that is imposed when we have a system as a tool work. It is essential for that what now arises in legal and criminal terms sees as the study of criminal law should be increasingly precise and also closer to the idea of human dignity. It will also be built a criticism for the two doctrines that have changed the face of the first systematic, designed in the nineteenth, which will allow us to see more accurately what can, or even should, be changed. One cannot help but praise the normativism, especially what received the indelible streng…