Search results for "RIO"

El diagnóstico de la crisis de la cultura en España: del recorte público a la crisis sistémica

2016

Since its invention in the fifties, cultural policy has been subject of analysis and reflection by Social Sciences. However, Spain, due to Franco period, has a number of distinguishing features as compared to Western European democracies. With the restoration of democracy, Spain acquires the dominant paradigm of a democratic cultural policy based on freedom, pluralism and the right to culture. However, after decades of democratic governments, diagnosis of cultural policy in Spain shows signs of systemic crisis, added to the impact of the global financial crisis at the beginning of the XXI century. In this context, scholars, using the Delphi method along with secondary sources, identify a se…

INFORMACIÓN Y EXPOSICIÓN INDIRECTA PARA REDUCIR ESTEREOTIPOS HACIA EL ENVEJECIMIENTO

2016

Abstract.Purpose: The Image that society has about older people has been built on a base of stereotypes, far away from reality. This social image will have a determinant influence on attitudes and behaviors from all those people related with them, including health care professionals. It should be mandatory to eradicate negative stereotypes against aging during university formation, and in this practice get sensitive professionals who will attend people in their final state of life. Method: the treatment “Information plus indirect experience” was set throw the viewing of the short film “Como un Rolling” (Castilla, 2013). This film exposes the concept of active aging, and had the purpose to b…

Back pain in a group of computer workers assessed in a physiotherapy unit

2021

BACKGROUND: Modern society work implies computer-based activities generating back pain because of prolonged sitting positions and non-ergonomic postures. OBJECTIVE: The aim of the study was to analyse the back-pain characteristics in a group of office workers in comparison with potential risk factors. METHODS: The design of the study was retrospective; a group of 109 computer workers with back pain was selected from a private physiotherapy unit between Jan 2018 - Dec 2019. Anthropometric, occupational and behaviour data, symptoms, the diagnosis on the first visit, previous medical diagnosis and specific physical activities were collected from medical records. RESULTS: The studied group (res…

Topographical geometric factors governing the biological activities of methomyl derivatives on binding receptors of maize mitochondria

1986

Abstract The topographical study of the binding receptors of T and N mitochondria was undertaken with methomyl derivatives acting as molecular probes. The two biological activities related to topography and geometric isomerism are distinguishable from the receptor sites of T and N mitochondria.

Cortical network mechanisms of response inhibition

2020

SummaryBoth the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, the particular functional roles of those two regions have been controversially debated for more than a decade now. It is unclear whether the rIFG directly initiates stopping or serves an attentional function, whereas the stopping is triggered by the pre-SMA. The current multimodal MEG/fMRI study sought to clarify the role and temporal activation order of both regions in response inhibition using a selective stopping task. This task dissociates inhibitory from attentional processes. Our results reliably reveal a temporal precedence of rIF…

Comparison of CRISPR and marker based methods for the engineering of phage T7

2020

With the recent rise in interest in using lytic bacteriophages as therapeutic agents, there is an urgent requirement to understand their fundamental biology to enable the engineering of their genomes. Current methods of phage engineering rely on homologous recombination, followed by a system of selection to identify recombinant phages. For bacteriophage T7, the host genescmkortrxhave been used as a selection mechanism along with both type I and II CRISPR systems to select against wild-type phage and enrich for the desired mutant. Here we systematically compare all three systems; we show that the use of marker-based selection is the most efficient method and we use this to generate multiple …

2019

Mitochondria have been increasingly recognized as a central regulatory nexus for multiple metabolic pathways, in addition to ATP production via oxidative phosphorylation (OXPHOS). Here we show that inducing mitochondrial DNA (mtDNA) stress in Drosophila using a mitochondrially-targeted Type I restriction endonuclease (mtEcoBI) results in unexpected metabolic reprogramming in adult flies, distinct from effects on OXPHOS. Carbohydrate utilization was repressed, with catabolism shifted towards lipid oxidation, accompanied by elevated serine synthesis. Cleavage and translocation, the two modes of mtEcoBI action, repressed carbohydrate rmetabolism via two different mechanisms. DNA cleavage activ…

Mitochondrial CB1 receptors regulate neuronal energy metabolism

2012

The mammalian brain is one of the organs with the highest energy demands, and mitochondria are key determinants of its functions. Here we show that the type-1 cannabinoid receptor (CB(1)) is present at the membranes of mouse neuronal mitochondria (mtCB(1)), where it directly controls cellular respiration and energy production. Through activation of mtCB(1) receptors, exogenous cannabinoids and in situ endocannabinoids decreased cyclic AMP concentration, protein kinase A activity, complex I enzymatic activity and respiration in neuronal mitochondria. In addition, intracellular CB(1) receptors and mitochondrial mechanisms contributed to endocannabinoid-dependent depolarization-induced suppres…

Les actions du chlorfenprop-methyl sur l'integrite membranaire dans les mitochondries des plantes

1983

Summary The action of chlorfenprop-methyl, chlorfenprop and its cysteine conjugate was studied on potato tuber mitochondria. Chlorfenprop-methyl altered membrane structure at 250 μM. leading to a loss of membrane integrity. Chlorfenprop and its cysteine conjugate were without any significant effects. From what is known about the rapid hydrolysis of chlorfenprop-methyl in plant tissues and from the results presented in this paper, it was deduced that alteration in intra-cellular membrane integrity is not a mechanism of phytotoxic action for chlorfenprop-methyl. Resume Les actions du chlorfenprop-methyl sur l'integrite membranaire dans les mitochondries des plantes Les actions du chlorfenprop…

An exploration of digital ride-hailing multisided platforms' market dynamics: empirical evidence from the Uber case study

2020

PurposeThe purpose of this paper is to experiment a dynamic performance management (DPM) approach to explore and assess the business dynamics of digital ride-hailing platforms with a focus on both supply and demand sides, and related interplays.Design/methodology/approachThe research adopts the DPM framework supported by simulation-based experimentations for developing a systemic case interpretation of Uber Inc. and its specific business complexity.FindingsThe emerging scenario analysis reveals that changes in the commission percentage for drivers and cutting prices for customers (car hailers) by competitors have significant impacts on the car-hailing industry.Originality/valueDPM and assoc…