6533b824fe1ef96bd1280bc7
RESEARCH PRODUCT
Cortical network mechanisms of response inhibition
Michael WibralPatrick JungAlexandra SebastianArian MobascherPascal FriesPascal FriesOliver TuescherOliver TuescherKlaus LiebKlaus LiebEdoardo PinzutiMichael Schaumsubject
0303 health sciences03 medical and health sciences0302 clinical medicineMotor areaRight inferior frontal gyrusCortical networkInhibitory postsynaptic potentialPsychologyNeuroscience030217 neurology & neurosurgeryResponse inhibition030304 developmental biologydescription
SummaryBoth the right inferior frontal gyrus (rIFG) and the pre-supplementary motor area (pre-SMA) are crucial for successful response inhibition. However, the particular functional roles of those two regions have been controversially debated for more than a decade now. It is unclear whether the rIFG directly initiates stopping or serves an attentional function, whereas the stopping is triggered by the pre-SMA. The current multimodal MEG/fMRI study sought to clarify the role and temporal activation order of both regions in response inhibition using a selective stopping task. This task dissociates inhibitory from attentional processes. Our results reliably reveal a temporal precedence of rIFG over pre-SMA. Moreover, connectivity during response inhibition is directed from rIFG to pre-SMA and predicts stopping performance. Response inhibition is implemented via beta-band oscillations. Our findings support the hypothesis that response inhibition is initiated by the rIFG as a form of attention-independent top-down control.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2020-02-10 |