Search results for "RITU"

Targeting B cells in relapsing–remitting multiple sclerosis: from pathophysiology to optimal clinical management

2017

Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease that is caused by an autoimmune response against central nervous system (CNS) structures. Traditionally considered a T-cell-mediated disorder, the contribution of B cells to the pathogenesis of MS has long been debated. Based on recent promising clinical results from CD20-depleting strategies by three therapeutic monoclonal antibodies in clinical phase II and III trials (rituximab, ocrelizumab and ofatumumab), targeting B cells in MS is currently attracting growing interest among basic researchers and clinicians. Many questions about the role of B and plasma cells in MS remain still unanswered, ranging from the role of…

Voluntary Running Aids to Maintain High Body Temperature in Rats Bred for High Aerobic Capacity

2016

The production of heat, i.e., thermogenesis, is a significant component of the metabolic rate, which in turn affects weight gain and health. Thermogenesis is linked to physical activity (PA) level. However, it is not known whether intrinsic exercise capacity, aging, and long-term voluntary running affect core body temperature. Here we use rat models selectively bred to differ in maximal treadmill endurance running capacity (Low capacity runners, LCR and High capacity Runners, HCR), that as adults are divergent for aerobic exercise capacity, aging, and metabolic disease risk to study the connection between PA and body temperature. Ten high capacity runner (HCR) and ten low capacity runner (L…

Safety and Clinical Activity of Temsirolimus in Combination with Rituximab and DHAP in Patients with Relapsed or Refractory Diffuse Large B-Cell Lymp…

2016

Abstract Purpose. To evaluate the safety, tolerability and efficacy of the combination of the mTOR inhibitor Temsirolimus and a standard salvage regimen (R-DHAP) in patients with relapsed or refractory diffuse large cell B-Cell lymphoma (DLBCL). Methods. This is a prospective, multicenter, phase II, open-label study. Patients with relapsed or refractory DLBCL with a maximum of two prior treatment lines were eligible. The STORM regimen consisted of Rituximab 375 mg/m² (day 2) and DHAP (Dexamethasone 40mg day 3-6, Cisplatine 100 mg/m² day 3, Cytarabine 2x2 g/m² day 4) with Temsirolimus added on day 1 and 8 of a 21 d cycle, with 2-4 cycles planned. In part I, dose levels of 25, 50, 75 and 100 …

The impact of rituximab infusion protocol on the long-term outcome in anti-MuSK myasthenia gravis

2018

ObjectiveTo evaluate whether the clinical benefit and relapse rates in anti-muscle-specific kinase (MuSK) myasthenia gravis (MG) differ depending on the protocol of rituximab followed. MethodsThis retrospective multicentre study in patients with MuSK MG compared three rituximab protocols in terms of clinical status, relapse, changes in treatment, and adverse side effects. The primary effectiveness endpoint was clinical relapse requiring a further infusion of rituximab. Survival curves were estimated using Kaplan-Meier methods and survival analyses were undertaken using Cox proportional-hazards models. ResultsTwenty-five patients were included: 11 treated with protocol 4 + 2 (375 mg/m(2)/4 w…

Defining sensory descriptors: towards writing rules based on terminology

2007

International audience; Descriptive analysis relies upon the use of sensory descriptors. They are words generally associated to a definition aimed at helping their understanding. However, the writing rules for such definitions remain implicit. The present work is a collaborative attempt from sensory analysts and linguists to get further insight into how definitions are elaborated.Definition formulations were analyzed according to linguistic criteria, syntactic (type and number of nouns, verbs and adjectives) as well as semantic ones (relations of synonymy, metaphor or analogy between the descriptors and their definitions). Such a linguistic analysis was performed on one hundred descriptor d…

Communication Practices and Social Tie Formation: A Case Study of Recreational Lifestyle Sports Cultures

2017

This case study examines contemporary recreational sports practitioners’ communication practices and social tie formation from the perspective of two lifestyle sports disciplines: climbing and trail running. Online survey results from 301 climbers and trail runners from Finland indicate that computer-mediated communication (CMC) has established its place in recreational lifestyle sports cultures; however, it has not done it at the expense of face-to-face (FtF) communication. Online interaction produces weak social ties with instrumental and informative value, but physical location is essential in establishing ties with emotional and appraisal value. This paper argues that it is the sports s…

L'apprentissage/enseignement de la morphologie écrite du nombre en français

1999

In written French forms play an essential role. Numerous morphological marks have no correspondence in oral French. This is the case of plural flexions : -s for the plural of nouns and adjectives and -nt for verbs at the third person of indicative present. Earlier research showed that on the one hand the interpretation of these marks precedes their production and that this nominal flexion proceeding appears earlier and more correctly than adjectival flexion proceeding and verbal flexion (-nt). On the other hand, overgeneralizations were tracked down thanks to this research work : faultly use of flexions especially nominal flexions attributed to verbs (ils timbres). But in these investigatio…

Lectura, escritura de mujeres y transmisión familiar en Lengua madre, de María Teresa Andruetto. Aprender de (pos)memoria

2019

El ritual festivo desde la perspectiva teórica de pierre bourdieu: el caso de las fallas de valencia.

2011

El objetivo de la presente contribución es apuntar nuevas perspectivas teóricas que permitan analizar la acción ritual en las sociedades modernas. Concretamente, se pondrá a prueba el concepto de campo, desarrollado por Pierre Bourdieu, como herramienta que nos permita acercarnos a una mejor comprensión de la fiesta de las Fallas. Se argumentará, en primer lugar, la pertinencia de la propuesta a partir de la bibliografía disponible para, a continuación, analizar desde una perspectiva sociohistórica la génesis y estructura del mundo fallero. Seguirán unas reflexiones sobre las relaciones de fuerzas en juego entre los agentes que compiten en dicho campo (ortodoxos y herejes); para concluir, s…

La traducció corellana de la Vita Christi de Ludolf de Saxònia (edició crítica i estudi traductològic del llibre Primer, València, 1496).

2015

Aquesta tesi doctoral porta a terme una edició filològica de la traducció valenciana del llibre Primer de la Vita Chisti de Ludolf de Saxònia (c.1295/1300-1377/78), que és la darrera de les grans vides de Crist llatines de l’Edat Mitjana, i un dels puntals de la literatura contemplativa de la tardor medieval. La fixació del text traduït per l'escriptor i teòleg Joan Roís de Corella s'ha portat a terme a partir de l'acarament de les dues edicions que ens l'han transmés: l'editio princeps valenciana de 1496, que s'ha pres com a text base, i l'edició barcelonina de 1518. El text s'acompanya de tres aparats de notes: el primer, de caràcter ecdòtic, recull el conjunt de variants que presenten le…