Search results for "RIZ"

BEST-2K Method for Characterizing Dual-Permeability Unsaturated Soils with Ponded and Tension Infiltrometers

2019

This study presents a new method (BEST-2K) that extends the existing BEST methods for use in characterizing the water retention and hydraulic conductivity functions of matrix and fast-flow regions in dual-permeability soils. BEST-2K requires input information from two water infiltration experiments that are performed under ponded (Beerkan) and unsaturated (tension infiltrometer) conditions at the surface. Other required inputs include water content measurements and the traditional BEST inputs (particle size distribution and bulk density). In this study, first, a flowchart of the BEST-2K method was developed and illustrated with analytically generated data for a synthetic dual-permeability s…

Failure Rate Measurement on Silicon Diodes Reverse Polarized at High Temperature

2017

This paper calculates the failure rate on reversed polarized silicon diodes with the aim to justify, experimentally, the rules of the European Space Agency (ESA) which are referred to the component life’s extension, the reliability increase and the end of life performance enhancement, by using oversized devices (derating rules). In order to verify the derating rules, 80 silicon diodes are used, which are reverse polarized in a high temperature environment. The diodes are divided in 4 groups of 20 diodes, applying a different voltage to each group, in order to relate the failure rate to the applied derating rule. The experiment described in this paper is developed using a temperature acceler…

Prototyping and Characterization of 1.2KV SIC Schottky Diodes for TWTA Application: The Challenge to Meet the User Specification

2017

Macrophages as an Emerging Source of Wnt Ligands: Relevance in Mucosal Integrity

2019

The Wnt signaling pathway is a conserved pathway involved in important cellular processes such as the control of embryonic development, cellular polarity, cellular migration, and cell proliferation. In addition to playing a central role during embryogenesis, this pathway is also an essential part of adult homeostasis. Indeed, it controls the proliferation of epithelial cells in different organs such as intestine, lung, and kidney, and guarantees the maintenance of the mucosa in physiological conditions. The origin of this molecular pathway is the binding between Wnt ligands (belonging to a family of 19 different homologous secreted glycoproteins) and their specific membrane receptors, from …

Tumor-Infiltrating γδ T Lymphocytes: Pathogenic Role, Clinical Significance, and Differential Programing in the Tumor Microenvironment.

2014

There is increasing clinical evidence indicating that the immune system may either promote or inhibit tumor progression. Several studies have demonstrated that tumors undergoing remission are largely infiltrated by T lymphocytes [tumor-infiltrating lymphocytes (TILs)], but on the other hand, several studies have shown that tumors may be infiltrated by TILs endowed with suppressive features, suggesting that TILs are rather associated with tumor progression and unfavorable prognosis. γδ T lymphocytes are an important component of TILs that may contribute to tumor immunosurveillance, as also suggested by promising reports from several small phase-I clinical trials. Typically, γδ T lymphocytes …

Cell therapy medicinal product regulatory framework in Europe and its application for MSC-based therapy development

2012

Advanced therapy medicinal products (ATMPs), including cell therapy products, form a new class of medicines in the European Union. Since the ATMPs are at the forefront of scientific innovation in medicine, specific regulatory framework has been developed for these medicines and implemented from 2009. The Committee for Advanced Therapies (CAT) has been established at the European Medicines Agency (EMA) for centralized classification, certification and evaluation procedures, and other ATMP-related tasks. Guidance documents, initiatives, and interaction platforms are available to make the new framework more accessible for small- and medium-sized enterprises, academia, hospitals, and foundation…

La educación en casa o homeschooling: la STC de 2 de diciembre de 2010

2011

[EN] This article analyses raising conflicts between children ́ education ́s right and freedom of education belonging to parents and tutors, according to the complex article 27 of Spanish Constitution, especially after the recent sentence of Constitucional Court dated from 2nd December 2010, all of this in relation with the possiblility of giving basic education not through compulsory education but homeschooling.

Il danno alla persona del lavoratore: il mobbing orizzontale

2011

Sommario:1. Il mobbing tra diritto civile e diritto del lavoro – 2. Il fenomeno mobbing: gli studi iniziali e la definizione – 3. Le concrete condotte integranti fattispecie di mobbing – 4. Onere della prova – 5. Il mobbing orizzontale – 6. L’elemento soggettivo di colpevolezza del da­tore di lavoro nella responsabilità ex art. 2087 c.c. per mobbing orizzontale

El aula de comunicación y lenguaje y la inclusión escolar: Dificultades y estrategias de intervención

2016

Este texto muestra un estudio de casos de dos alumnos escolarizados en el aula de Comunicación y Lenguaje de un colegio valenciano. El objetivo principal se centra en conocer la situación de inclusión educativa de estos alumnos. Para llevarlo a cabo, se ha recogido una serie de datos utilizando hojas de registro de observaciones, entrevistas, encuestas, conversaciones informales y un diario de campo que han permitido realizar un análisis cualitativo de los mismos. Se han descrito las dificultades que obstaculizan el paso del aula CyL al aula ordinaria y se ha analizado la correspondencia entre las diferentes estrategias de intervención. Con los resultados obtenidos, reflexionamos sobre el g…

Interrelaciones entre acción y cognición. Aportaciones de la neurociencia a la educación rítmico-musical

2020

Body movement has played an important role in music education and there appears to be a consensus that it is one of the most effective means to develop rhythmic skills. In this article, we relate and analyze recent findings of neurocognitive research that support formative actions in this direction. Some results show that the link between sensory and motor systems provides a sophisticated mechanism of temporal prediction and feedback, which has led to the belief that body expression influences the way certain rhythmic elements are perceived. Finally, we propose some suggestions for rhythm education in school and cross training perspectives related to the link between music and movement. El …