Search results for "RNAs"

The 2-5A System and HIV Infection

1994

The human immunodeficiency virus type 1 (HIV-1) is the etiologic agent of acquired immunodeficiency syndrome (AIDS). The progression of this retro viral disease is associated with various clinical manifestations, including the acquisition of an immunodeficient state, the frequent presence of neurological disorders, and some malignancies (reviewed in Barre-Sinoussi et al. 1983; Wong-Staal and Gallo 1985; Fauci 1988). Immunologic dysfunctions caused by HIV-1 infection include disorders in the production of cytokines (Murray et al. 1984; Abb et al. 1986). For example, a significant decrease in the production of interferon-α (IFN-α) by cultured peripheral blood mononuclear cells (PBMC) from pat…

Differentiated Integration and Disintegration in the EU after Brexit : Risks versus Opportunities

2019

Differentiation is becoming an increasingly salient feature of European integration. The multi‐faceted European crisis and the subsequent Brexit vote (paving the way for a ground‐breaking case of differentiated disintegration) have led scholars and practitioners to think about the consequences of differentiated integration. This article draws on five well‐established models of differentiation experienced by countries both inside and outside the Union: the EEA model; the Danish model of (quasi‐)permanent differentiation; the Swedish model of de facto differentiation; the instrumental model; and the British model of differentiated disintegration. It addresses the different risks and opportuni…

Constitutive Promoter Occupancy by the MBF-1 Activator and Chromatin Modification of the Developmental Regulated Sea Urchin α-H2A Histone Gene

2007

The tandemly repeated sea urchin alpha-histone genes are developmentally regulated. These genes are transcribed up to the early blastula stage and permanently silenced as the embryos approach gastrulation. As previously described, expression of the alpha-H2A gene depends on the binding of the MBF-1 activator to the 5' enhancer, while down-regulation relies on the functional interaction between the 3' sns 5 insulator and the GA repeats located upstream of the enhancer. As persistent MBF-1 binding and enhancer activity are detected in gastrula embryos, we have studied the molecular mechanisms that prevent the bound MBF-1 from trans-activating the H2A promoter at this stage of development. Her…

Hsa-miR-30d, secreted by the human endometrium, is taken up by the pre-implantation embryo and might modify its transcriptome.

2015

During embryo implantation, the blastocyst interacts with and regulates the endometrium, and endometrial fluid secreted by the endometrial epithelium nurtures the embryo. Here, we propose that maternal microRNAs (miRNAs) might act as transcriptomic modifier of the pre-implantation embryo. Microarray profiling revealed that six of 27 specific, maternal miRNAs were differentially expressed in the human endometrial epithelium during the window of implantation – a brief phase of endometrial receptivity to the blastocyst – and were released into the endometrial fluid. Further investigation revealed that hsa-miR-30d, the expression levels of which were most significantly upregulated, was secreted…

Anaerobic membrane bioreactors for resource recovery from municipal wastewater: a comprehensive review of recent advances

2021

[EN] In a paradigm shift towards a sustainable society based on the Circular Economy, wastewater treatments are rapidly evolving towards simultaneous recovery and reuse of clean water, renewable energy, and nutrients. This review examines recent advances (from 2016 to 2020) in the potential of anaerobic membrane bioreactors (AnMBRs) to serve as the core technology for municipal wastewater (MWW) resource recovery, focusing on the latest technological advances and economic and environmental innovation perspectives. The potentials and limitations of AnMBR for further full-scale application and new platforms to address these challenges are discussed, covering systems based on co-digestion, pre-…

Estats col · lapsats, les administracions internacionals, l'ocupació i els neo-protectorats

2012

Xerrada sobre els estats col · lapsats, les administracions internacionals, l'ocupació i els neo-protectorats.

Sesión apologética dedicada á D. Rafael Cisternas y Fontseré : discurso leído en la apertura de curso de 1894 del Instituto Médico Valenciano

1894

Clinical and immunological aspects of microRNAs in neonatal sepsis

2022

Abstract Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regulation by short non-coding RNAs (e.g., microRNAs) have recently acquired special relevance because of their role in the regulation of the pathophysiology of sepsis and their potential clinical use as biomarkers. ~22-nucleotide of microRNAs are not only involved in regulating multiple relevant cellular and molecular functions, such as immune cell function and inflammatory response, but have…

Epigenetic biomarkers: A new perspective in laboratory diagnostics.

2012

Epigenetics comprises the study of chemical modifications in the DNA and histones that regulates the gene expression or cellular phenotype. However, during the last decade this term has evolved after the elucidation of different mechanisms (microRNAs and nuclear organization of the chromosomes) involved in regulating gene expression. Epigenetics and the new designed technologies capable to analyze epigenetic changes (e.g., methylated DNA, miRNAs expression, post-translational modifications on histones among others) have disclosed an appealing scenario that will offer for the biomedical sciences new biomarkers for the study of neurodegenerative diseases, multifactorial complex diseases, rare…

Science and Healthy Meals in the World: Nutritional Epigenomics and Nutrigenetics of the Mediterranean Diet

2020

The Mediterranean Diet (MD), UNESCO Intangible Cultural Heritage of Humanity, has become a scientific topic of high interest due to its health benefits. The aim of this review is to pick up selected studies that report nutrigenomic or nutrigenetic data and recapitulate some of the biochemical/genomic/genetic aspects involved in the positive health effects of the MD. These include (i) the antioxidative potential of its constituents with protective effects against several diseases; (ii) the epigenetic and epigenomic effects exerted by food components, such as Indacaxanthin, Sulforaphane, and 3-Hydroxytyrosol among others, and their involvement in the modulation of miRNA expression; (iii) the …