Search results for "RNAs"
showing 10 items of 710 documents
Joan Roís de Corella, la seua vida i el seu entorn: noves dades per a la història de la cultura en la València del segle xv
2014
This article offers a full updating of the biographical records of the writer Joan Roís de Corella (1435-1497) and his family: his great-grandparents, grandparents, parents, siblings and children. All data are presented in a systematic way, generation by generation, and a new vision of the writer himself is offered. In its documentary section, 432 documents are transcribed or summarised, dating from 1373 to 1516. A broad range of new archival data is presented; other previously known data are corrected or improved. Some examples: Joan Roís de Corella had four children: Magdalena (born 1459), Maria, Joan and Estefania, the latter two by Isabel Martínez de Vera. Joan Roís de Corella was widel…
Dante en la cultura Catalana a l'entorn del casal de Barcelona (1381-1410/12)
2016
This article analyzes in a historical context the earliest evidences of Dante’s influence on Catalan culture during the reigns of Kings Peter IV, John I and Martin of Aragon, until the interregnum (1410-12) and the change of dynasty resulting from the Compromise of Caspe (1412). French courts, Avignon papal curia and the close personal, political and dynastic ties between the kingdoms of Sicily and Aragon constitute the background on which this paper studies the many echoes of Dante —from the Commedia, from the commentaries on Dante and from the so-called silloge boccaccesca— to be found around the chancellery and the court of Aragon: specifically, in Bernat Metge’s Llibre de Fortuna e Prud…
La iconografía en la era digital: hacia una heurística para el estudio del contenido de las imágenes medievales
2014
Este artículo invita a reflexionar sobre la validez de la iconografía como método para describir los temas representados en las obras artísticas medievales. En esta ocasión, se ha puesto un mayor énfasis en investigar sus implicaciones epistemológicas y los sesgos que resultan del proceso de transformar las imágenes en palabras. El objetivo principal es tratar de que aflore la llamada 'brecha semántica', una especie de barrera que impide representar verbalmente un medio no léxico, como es el visual, de manera satisfactoria y sin mermas. Tras un sucinto recorrido por el pensamiento griego, con un especial interés por la écfrasis, se sugiere que el aparente equilibrio entre las capacidades se…
Les "Razos de trobar" de Ramon Vidal: una gramàtica per al cant
2015
The Razos de trobar are revisited in this paper, with a recapitulation of the learned opinions on this text’s subject, and a new evaluation of it as a grammar handbook for troubadours. Characteristics are set down which differentiate this work from others like Uc Faidit’s Donatz proensals and Jofre de Foixa’s Regles de trobar . Attention is also given to the possible reasons for this text’s popularity, and on the way, Ovidian sources are retraced for the famous final lines (37-39) of Arnaut Daniel’s “Ab gai so cundet et leri”: “Ieu sui Arnautz qu’amas l’aura...”
Joan Roís de Corella, Lamentació de Mirra, de Narciso, de Píramus i Tisbe: edizione critica
2016
Il contributo, che è un’anticipazione parziale dell’edizione critica integrale delle narrazioni mitologiche di Joan Roís de Corella (XV sec.) per Barcino (ENC), nasce dall’esigenza di rivedere la situazione testuale della faula in oggetto (Lamentació de Mirra, de Narciso, de Píramus i Tisbe) e di avanzare, dove necessario, nuove proposte di lettura. Esso consta di due parti, delle quali la prima contiene l’Introduzione, la seconda il Testo con note a piè di pagina, in cui si discutono questioni relative alla constitutio textus, l’Apparato e l’Apparato complementare. Nell’Introduzione si danno informazioni essenziali circa la tradizione manoscritta delle Lamentacions (altrimenti note come Lo…
Transcribing the "Estoria de Espanna" using crowdsourcing: Strategies and aspirations
2015
This paper examines the specific strategies for recruitment and retention of volunteer transcribers in use in two collaborative transcription projects: Transcribe Bentham (University College, London) and the Estoria de Espanna Digital Project (University of Birmingham). The aim of the paper is to review the strategies used by Transcribe Bentham, a more mature crowdsourced electronic transcription project, with a view to informing the strategies put into place in the Estoria project, which has started transcribing using crowdsourcing more recently. The paper discusses the difficulties faced by crowdsourced electronic transcription projects and how these have been and are being resolved in th…
Carlo Ginzburg. Cuando el historiador amoneda un símbolo
2020
Resumen En este artículo pretendemos analizar la trayectoria, la contribución, los resultados y la influencia de un historiador de renombre mundial, Carlo Ginzburg. La suya es una investigación de largo recorrido, cuya influencia se ha dado no sólo en esta rama del saber, sino también en muy distintos ámbitos de las humanidades, de las ciencias, de las artes. Carlo Ginzburg ha sido reconocido e identificado principalmente a partir de dos logros historiográficos: la microhistoria y El queso y los gusanos. Por un lado, se le ve como el máximo representante de la microhistoria, la corriente de origen italiano que se expande principalmente en los años ochenta del siglo XX. Por otro lado, a este…
Efficient Reprogramming of Human Fibroblasts and Blood-Derived Endothelial Progenitor Cells Using Nonmodified RNA for Reprogramming and Immune Evasion
2015
mRNA reprogramming results in the generation of genetically stable induced pluripotent stem (iPS) cells while avoiding the risks of genomic integration. Previously published mRNA reprogramming protocols have proven to be inconsistent and time-consuming and mainly restricted to fibroblasts, thereby demonstrating the need for a simple but reproducible protocol applicable to various cell types. So far there have been no published reports using mRNA to reprogram any cell type derived from human blood. Nonmodified synthetic mRNAs are immunogenic and activate cellular defense mechanisms, which can lead to cell death and inhibit mRNA translation upon repetitive transfection. Hence, to overcome RNA…
Evolutionary conservation and function of the human embryonic stem cell specific miR-302/367 cluster
2015
miRNA clusters define a group of related miRNAs closely localized in the genome with an evolution that remains poorly understood. The miR-302/367 cluster represents a single polycistronic transcript that produces five precursor miRNAs. The cluster is highly expressed and essential for maintenance of human embryonic stem cells. We found the cluster to be highly conserved and present in most mammals. In primates, seed sequence and miRNA structure are conserved, but inter-precursor sequences are evolving. Insertions of new miRNAs, deletions of individual miRNAs, and a cluster duplication observed in different species suggest an actively evolving cluster. Core transcriptional machinery consisti…
Defining minimum runoff length allows for discriminating biocrusts and rainfall events
2021
This study was started in the context of the research projects PECOS (REN2003-04570/GLO) and PREVEA (CGL2007-63258/BOS) , both funded by the Spanish National Plan for RD&I and by the European ERDF Funds (European Regional Development Fund) , and continued during the project SCIN (Soil Crust In-terNational, PRI-PIMBDV-2011-0874, European project of ERA-NET BIODIVERSA, the Spanish team being funded by the Spanish Ministry of Economy and Competitiveness) . The work was finally supported and culminated by the DINCOS project (CGL2016-78075-P, Spanish State Programme for Scientific Research) and by the European ERDF Funds (Euro-pean Regional Development Fund) . Consuelo Rubio's partici-pation was…