Search results for "ROH"
showing 10 items of 730 documents
HLA-B27-restricted cytotoxic T lymphocyte responses to arthritogenic enterobacteria or self-antigens are dominated by closely related TCRBV gene segm…
1996
Identification of the T-cell receptors (TCR) used by synovial cytotoxic T lymphocytes (CTL) of patients with reactive arthritis (ReA) may be crucial to better understanding the pathogenetic mechanism underlying the HLA-B27 association of spondylarthropathies. The authors, therefore, sequenced 25 TCRB chains from HLA-B27-restricted CD8+ CTL clones and two clonal lines specific for self- or Yersinia enterocolitica antigen isolated from synovial fluids of 3 HLA-B27+ patients with ReA and PBL of one healthy HLA-B27+ individual. Fourteen non-HLA-B27-restricted CTL served as controls. Both autoreactive and Y. enterocolitica specific HLA-B27-restricted CTL used a highly limited set of VB genes wit…
Infliximab, azathioprine or combination therapy in the treatment of active Crohn's disease.
2010
The treatment of moderate-to-severe steroid-dependent Crohn's disease has been a challenging issue for the gastroenterologist. Until to 10 years ago, immunosuppressors, mainly azathioprine or 6-mercaptopurine, were the best possible treatments available, and remission rates ranged from 30 to 60% according to the results of open studies and controlled trials. Recently, infliximab has been shown to be effective in steroid-dependent patients and, combined with azathioprine, it has been shown to increase 1-year remission rates. A recent large randomized controlled trial comparing infliximab, azathioprine and infliximab plus azathioprine demonstrated that the combination of infliximab plus azath…
Identification of the Yersinia enterocolitica urease beta subunit as a target antigen for human synovial T lymphocytes in reactive arthritis.
1993
The local T-cell response to bacterial antigens is involved in the pathogenesis of reactive arthritis (ReA). Here, we have identified a 19-kDa antigen of Yersinia enterocolitica O:9 recognized by Yersinia-specific synovial fluid CD4+ T cells in two patients with Yersinia-induced ReA. N-terminal amino acid sequencing of this protein revealed that it was identical to the 19-kDa urease beta subunit of Y. enterocolitica O:9. This protein has previously been shown to be arthritogenic in preimmunized rats after intra-articular injection. Analysis of the T-cell response to this protein showed that it contains several T-cell epitopes, one of which cross-reacts with other enterobacteria not able to …
Anti-TNF-Antikörper zur Therapie von entzündlichen Darmstenosen bei Morbus Crohn
2003
Stenoses are a frequent complication in patients with Crohn's disease and represent a major diagnostic and therapeutic challenge. The proper assessment of the nature of a stenosis as inflammatory or fibrotic is critical for appropriate treatment, since symptomatic fibrotic stenoses require surgical resection. Standard diagnostic procedures to assess the nature of a stenosis include endoscopy, conventional contrast radiography and magnetic resonance tomography. Recent data suggest, that the positron-emission-tomography possesses a high sensitivity and specificity to confirm inflammatory activity in the bowel. The recombinant monoclonal anti-TNF-antibody Infliximab (Remicade) has been approve…
Emergence of severe spondyloarthropathy-related entheseal pathology following successful vedolizumab therapy for inflammatory bowel disease
2018
Objectives Vedolizumab (VDZ) blocks α4β7 integrin and is licenced for the treatment of IBD. It has been associated with mild SpA-related features, including sacroiliitis and synovitis. Herein we report a series of cases demonstrating the emergence of severe SpA-associated enthesitis/osteitis following successful IBD therapy with VDZ. Methods We evaluated 11 VDZ-treated patients with IBD across seven centres who developed severe active SpA and/or enthesopathy, with the aim of characterizing the VDZ-associated SpA or entheseal flares. Imaging features demonstrating particularly severe disease were recorded. Results De novo SpA developed in 9 of 11 patients and flare of known SpA in 2 patients…
Dyskeratosis congenita: Report of a case with literature review
2007
Leukoplakic lesion is not uncommon in clinical practice but its occurrence as a component of a syndrome is rare. Dyskeratosis congenita is a rare genodermatosis, which is characterized by triad of skin pigmentation, nail dystrophy and leukoplakic lesion in the oral cavity. It is important for dentists to now about Dyskeratosis Congenita because these leukoplakic lesions can spontaneously undergo malignant transformation. Majority of cases have been reported in dermatology or pediatrics literature whereas only few reports have appeared in dental literature. The purpose of reporting this case with review of recent literature is to create better awareness among dentists about the multisystem m…
I den folkliga modedräktens fotspår : bondekvinnors välstånd, ställning och modemedvetenhet i Gamlakarleby socken 1740-1800
2018
My research study deals with the wealth, social position, and fashion awareness of farmers’ wives in Gamlakarleby (Kokkola) parish in the latter half of the eighteenth century. In addition, I investigate the picture that present national costumes give about eighteenth century dressing. The aim is to examine farmer wives’ wealth in the villages of Karleby (Gamlakarleby socken) and the village of Nedervetil, which were part of the class society regulated by the Church Law of 1686 and the Swedish Civil Code enacted in 1734. The perspective of my research is microhistorical, which means that I study individual persons and phenomena in the villages of Gamlakarleby parish, and I mention the perso…
Sexual segregation of Echinorhynchus borealis von Linstow, 1901 (Acanthocephala) in the gut of burbot (Lota lota Linnaeus)
2015
Helminths often occupy defined niches in the gut of their definitive hosts. In the dioecious acanthocephalans, adult males and females usually have similar gut distributions, but sexual site segregation has been reported in at least some species. We studied the intestinal distribution of the acanthocephalan Echinorhynchus borealis von Linstow, 1901 (syn. of E. cinctulus Porta, 1905) in its definitive host, burbot (Lota lota Linnaeus). Over 80% of female worms were found in the pyloric caeca, whereas the majority of males were in the anterior two-thirds of the intestine. This difference was relatively consistent between individual fish hosts. Worms from different parts of the gut did not dif…
Underground multi-muon experiment EMMA
2011
EMMA is a new experiment designed for cosmic-ray composition studies around the knee energy operating at the shallow depth underground in the Pyhäsalmi mine, Finland. The array has sufficient coverage and resolution to determine the multiplicity, the lateral density distribution and the arrival direction of high-energy muons on an event by event basis. Preliminary results on the muon multiplicity extracted using one detector station of the array are presented. peerReviewed
Viidesluokkalaisten ja luokanopettajien käsityksiä omasta historiasta
2013
Joonas Savolainen. Viidesluokkalaisten ja luokanopettajien käsityksiä omasta historiasta. Kasvatustieteen pro gradu -työ. Jyväskylän yliopiston opettajankoulutuslaitos, 2013. 68 sivua. Julkaisematon. Tutkimuksessa selvitettiin millaisia käsityksiä ja kokemuksia viidesluokkalaisilla ja luo-kanopettajilla on omasta historiastaan. Lisäksi luokanopettajilta kysyttiin, miten heidän mielestään oppilaan omaa historiaa voidaan hyödyntää opetuksessa. Tutkimuksen tavoit-teena oli selvittää mistä oppilaiden ja opettajien käsitykset omasta historiasta rakentuvat ja mitä ne sisältävät. Oppilaiden ja opettajien käsityksiä ei ole juuri tutkittu omaan historiaan liittyen. Opetussuunnitelmassa kuitenkin oma…