Search results for "ROSAT"
showing 10 items of 520 documents
Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis
2011
Heat shock proteins (HSPs) are necessary for cancer cell survival. We identified a mutant of HSP110 (HSP110ΔE9) in colorectal cancer showing microsatellite instability (MSI CRC), generated from an aberrantly spliced mRNA and lacking the HSP110 substrate-binding domain. This mutant was expressed at variable levels in almost all MSI CRC cell lines and primary tumors tested. HSP110ΔE9 impaired both the normal cellular localization of HSP110 and its interaction with other HSPs, thus abrogating the chaperone activity and antiapoptotic function of HSP110 in a dominant-negative manner. HSP110ΔE9 overexpression caused the sensitization of cells to anticancer agents such as oxaliplatin and 5-fluorou…
Fragmentation-related patterns of genetic differentiation in pedunculate oak (Quercus robur) at two hierarchical scales
2016
Populations at species' range margins are expected to show lower genetic diversity than populations at the core of the range. Yet, long-lived, widespread tree species are expected to be resistant to genetic impoverishment, thus showing comparatively high genetic diversity within populations and low differentiation among populations. Here, we study the distribution of genetic variation in the pedunculate oak (Quercus robur L.) at its range margin in Finland at two hierarchical scales using 15 microsatellite loci. At a regional scale, we compared variation within versus among three oak populations. At a landscape scale, we examined genetic structuring within one of these populations, growing …
Impairment of PGC-1 Alpha Up-Regulation Enhances Nitrosative Stress in the Liver during Acute Pancreatitis in Obese Mice
2020
Acute pancreatitis is an inflammatory process of the pancreatic tissue that often leads to distant organ dysfunction. Although liver injury is uncommon in acute pancreatitis, obesity is a risk factor for the development of hepatic complications. The aim of this work was to evaluate the role of PGC-1&alpha
PSMA6 gēna promotera poliadenozīna trakta polimorfismu asociācija ar bronhiālo astmu, aptaukošanos un 1. tipa cukura diabētu Latvijas populācijā
2015
Ubikitīna – proteasomu sistēma ir multienzīmatisks proteāžu komplekss, kas regule dažādus šūnu procesus. Šis sistēmas disregulācija var būt iesaistīta tādos cilvēka patoloģiju rašanās mehanismos kā 2. tipa cukura diabēts, juvenīlais idiopātiskais artrīts un Greivsa slimība. Tas var būt atkarīgs no proteasomas gēnu strukturālām pārmaiņām, kuri kodē proteasomu apakšvienības. Šajā pētījumā mēs analizējam asociāciju starp PSMA6 gēna promotera poly(A) (c. –655 An) mikrosatelīta garuma izmaiņām un bronhiālo astmu (BA), 1. tipa cukura diabētu (T1DM) un aptaukošanos (APT) Latvijas populācijā. PSMA6 gēna poly(A) polimorfisms tika analizēts ar gadījuma / kontroles pētījumu un bioinformātiskām program…
STR genotyping and mtDNA sequencing of latent fingerprint on paper
2003
A systematic study was conducted to investigate whether DNA can be successfully extracted from latent fingerprints deposited on ordinary paper and analysed using short tandem repeat profiling and mitochondrial DNA sequencing. In order to evaluate the performance of latent fingerprint analysis in a criminal case, experiments with varying conditions were carried out to improve our understanding of low copy number (LCN) DNA typing. After optimising the extraction methods to achieve increased sensitivity, the examination of touched paper can routinely yield the STR profile of the individual who has touched it. A fingerprint can therefore be considered as a potential source of DNA for genetic id…
Population differentiation in the marginal populations of the great tit (Paridae: Parus major)
2007
The major subspecies group of the great tit, Parus major, has experienced demographic and spatial expansions during the last century in several sites at the edges of its distribution range. These expansions, although temporarily very even, have resulted in dissimilar patterns of molecular diversity. Populations locating at regions of contact to other subspecies groups (in Amur, Kirghizia–Kazakhstan, and Iran) show divergence from central population by nuclear and mitochondrial markers. In Amur, gene flow from minor group could be detected based on the existence of private minor alleles in the major population. In Kirghizia and Kazakhstan, the bokharensis and major groups share almost all th…
Microsatellite Instability in Colorectal Cancer: Time to Stop Hiding!
2011
Colorectal cancer (CRC) is the second cause of cancer-related death worldwide. Surgery constitutes the primary therapy for these tumors, together with chemotherapy that is usually recommended in patients with metastatic primary CRC. Although molecularly distinct entities arising from different physiopathogenic mechanisms - microsatellite (MSI) and chromosomal instability (also called microsatellite stable, MSS) - have been characterized in CRC, there is still no specific therapeutic approach that takes into account disease’s molecular heterogeneity [1]. MSI is observed in 1015% of sporadic CRCs. MSI CRCs displayed particular morphologic features, with greater predilection for the right colo…
Evidence of a flip-flop phenomenon in acamprosate pharmacokinetics: an in vivo study in rats.
2006
The pharmacokinetics of acamprosate were examined in the rat after oral and intravenous administration in order to detect the possible presence of a flip-flop phenomenon. Rats received 9.3 or 73.3 mg/kg of the drug as an intravenous bolus. The same doses were orally administered via gastric intubation. Plasma samples were taken from the jugular vein for determination of acamprosate concentration by liquid scintillation counting. The drug content was also quantified in urine and faeces. The acamprosate bioavailability was close to 20%, the amount recovered in the faeces being around 80% of the administered dose. The terminal slope of the oral plasma curve was significantly lower than that ob…
XMM-Newton observations of the young open cluster Blanco 1. II. X-ray time variability and flares.
2005
We study the X-ray variability of the young open cluster Blanco 1 observed with the EPIC camera on board the XMM-Newton X-ray observatory. The time coverage of EPIC observations has allowed us to address short time scale (hours) variability, while the comparison with previous ROSAT observations has allowed us to investigate the variability on time scale of six years. On the time scale of hours, dM stars of the cluster are more variable than solar-mass stars. The main features of X-ray light curves in dM stars appear to be essentially flare-like events with a typical duration of the order of a few ks, while dF-dG stars show smooth variations. Two intense flares were observed in the ZS76 clus…
The Sun as an X‐Ray Star. IV. The Contribution of Different Regions of the Corona to Its X‐Ray Spectrum
2001
We study X-ray-synthesized spectra of solar regions as templates to interpret analogous stellar spectra. We define three classes of coronal structures of different brightness, low (background quiet corona), medium (active regions), and high (active region cores), and determine their contribution to the solar X-ray emission measure versus temperature, EM(T), luminosity, and spectrum. This study defines the extent of the solar analogy quantitatively and accurately. To this end, we have selected a large sample of full-disk Yohkoh soft X-ray telescope observations taken between the maximum and the minimum of solar cycle 22, obtaining the contribution of each class to the whole Sun's EM(T). From…