Search results for "ROSCA"
showing 10 items of 72 documents
Impact of non-alcoholic fatty liver disease on cardiovascular risk in a general population
2020
Background and aim: Nonalcoholic fatty liver (NAFL) is a major cause of liver disease worldwide leading also to a higher risk of cardiovascular events. We aimed to evaluate the impact of fatty liver and fibrosis on cardiovascular risk factors in a general population. Materials and methods: 604 subjects included in the communitybased ABCD (Alimentazione, Benessere Cardiovascolare e Diabete) study were recruited. Steatosis (CAP >288 dB/m) and fibrosis (>8.7 KPa by M and >7.2 KPa by XL probe) were assessed with FibroScan. Cardiovascular risk was evaluated by the Atherosclerotic Cardiovascular Disease (ASCVD) risk estimator and defined low if <5%, borderline if 5%-7.4%, intermediate…
Dynamics of a Ferromagnetic Particle Levitated Over a Superconductor
2018
Under conditions where the angular momentum of a ferromagnetic particle is dominated by intrinsic spin, applied torque is predicted to cause gyroscopic precession of the particle. If the particle is sufficiently isolated from the environment, a measurement of spin precession can potentially yield sensitivity to torque beyond the standard quantum limit. Levitation of a micron-scale ferromagnetic particle above a superconductor is a possible method of near frictionless suspension enabling observation of ferromagnetic particle precession and ultrasensitive torque measurements. We experimentally investigate the dynamics of a micron-scale ferromagnetic particle levitated above a superconducting …
Forming-Free and Self-Rectifying Resistive Switching Effect in Anodic Titanium Dioxide-Based Memristors
2018
The paper presents the resistive switching of electroforming-free Ti/anodic- TiO 2 /Cu memristors. Anodic TiO 2 thin films were prepared by anodizing Ti layers. Microscale devices were fabricated by direct laser-assisted photolithography. Experimental results showed a bipolar and self-rectifying behavior of the devices, which could be useful for crossbar array configurations. Moreover, a gradual resistive switching of the devices in both directions was observed, indicating the presence of multi-level resistance states.
The guanidinium group as a key part of water-soluble polymer carriers for siRNA complexation and protection against degradation.
2014
Here, the preparation of a novel block copolymer consisting of a statistical copolymer N-(2-hydroxypropyl) methacrylamide-s-N-(3-aminopropyl) methacrylamide and a short terminal 3-guanidinopropyl methacrylamide block is reported. This polymer structure forms neutral but water-soluble nanosized complexes with siRNA. The siRNA block copolymer complexes are first analyzed using agarose gel electrophoresis and their size is determined with fluorescence correlation spectroscopy. The protective properties of the polymer against RNA degradation are investigated by treating the siRNA block copolymer complexes with RNase V1. Heparin competition assays confirm the efficient release of the cargo in vi…
Microscale magnesium distribution in shell of the Mediterranean mussel Mytilus galloprovincialis: An example of multiple factors controlling Mg/Ca in…
2019
Abstract Since magnesium concentration (Mg/Ca) in biogenic calcite is considered to reflect water temperature during precipitation, the magnesium-to‑calcium ratio has been examined as a proxy for water temperature in paleoclimate research, although factors other than temperature may also influence Mg/Ca in biogenic calcite, thereby introducing a potential bias in the relationship between Mg/Ca and temperature observed in inorganic systems. To better understand factors controlling Mg incorporation into the calcitic shells of bivalves, the distribution of Mg in the Mediterranean mussel Mytilus galloprovincialis was studied, being compared with ambient sea surface temperature (SST), shell grow…
Reliability of liver stiffness measurement in non-alcoholic fatty liver disease: the effects of body mass index.
2011
Background Liver stiffness measurement (LSM) using transient elastography (TE) is used to stage fibrosis in patients with liver disease, diagnostic reliability and the factors affecting its performance in patients with non-alcoholic fatty liver disease (NAFLD) are incompletely understood. Aim To assess LSM. Methods Consecutive NAFLD patients (n = 169), assessed by liver biopsy (Kleiner score), anthropometrical, biochemical and metabolic features, underwent LSM using TE with standard M probe. Results Liver stiffness measurement was not reliable in 23 patients (14%) due to obesity. Among patients with a reliable TE, a LSM value >7.25 kPa was the best cut-off for predicting significant fibrosi…
The Interaction Mechanism of Intrinsically Disordered PP2A Inhibitor Proteins ARPP-16 and ARPP-19 With PP2A
2021
Protein phosphatase 2A (PP2A) activity is critical for maintaining normal physiological cellular functions. PP2A is inhibited by endogenous inhibitor proteins in several pathological conditions including cancer. A PP2A inhibitor protein, ARPP-19, has recently been connected to several human cancer types. Accordingly, the knowledge about ARPP-19—PP2A inhibition mechanism is crucial for the understanding the disease development and the therapeutic targeting of ARPP-19—PP2A. Here, we show the first structural characterization of ARPP-19, and its splice variant ARPP-16 using NMR spectroscopy, and SAXS. The results reveal that both ARPP proteins are intrinsically disordered but contain transient…
Assessment by Fibroscan of fibrosis in nonalcoholic fatty liver disease: XL versus M probe?
2012
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Is there a microbial sub alpha-diversity at soil microscale ?
2012
The distribution of the soil microbial diversity depends on a broad range of environmental filters nested in spatial scales from continent to millimeter. Although microbial biogeography studies have recently shown the influence of environmental factors (texture/pH/plant cover and land-use) on soil microbial abundance and diversity, little is still known about spatial heterogeneity at a micro-scale within soil. Our study aims at describing and understanding the distribution of abundance and diversity of soil microbial communities between different soil microenvironments. Four soils were selected on the basis of differences in physico-chemical properties and historical land-management practic…
Absolute quantification of noncoding RNA by microscale thermophoresis
2019
Abstract Accurate quantification of the copy numbers of noncoding RNA has recently emerged as an urgent problem, with impact on fields such as RNA modification research, tissue differentiation, and others. Herein, we present a hybridization‐based approach that uses microscale thermophoresis (MST) as a very fast and highly precise readout to quantify, for example, single tRNA species with a turnaround time of about one hour. We developed MST to quantify the effect of tRNA toxins and of heat stress and RNA modification on single tRNA species. A comparative analysis also revealed significant differences to RNA‐Seq‐based quantification approaches, strongly suggesting a bias due to tRNA modifica…