Search results for "RSE"
showing 10 items of 11150 documents
Anisotropy and chemical composition of ultra-high energy cosmic rays using arrival directions measured by the Pierre Auger Observatory
2011
The Pierre Auger Collaboration has reported evidence for anisotropy in the distribution of arrival directions of the cosmic rays with energies $E>E_{th}=5.5\times 10^{19}$ eV. These show a correlation with the distribution of nearby extragalactic objects, including an apparent excess around the direction of Centaurus A. If the particles responsible for these excesses at $E>E_{th}$ are heavy nuclei with charge $Z$, the proton component of the sources should lead to excesses in the same regions at energies $E/Z$. We here report the lack of anisotropies in these directions at energies above $E_{th}/Z$ (for illustrative values of $Z=6,\ 13,\ 26$). If the anisotropies above $E_{th}$ are du…
Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by su…
2010
Cholesterol-lowering drugs such as statins influence the proteolytic processing of the amyloid-beta protein precursor (AbetaPP) and are reported to stimulate the activity of alpha-secretase, the major preventive secretase of Alzheimer's disease. Statins can increase the alpha-secretase activity by their cholesterol-lowering properties as well as by impairment of isoprenoids synthesis. In the present study, we elucidate the contribution of these pathways in alpha-secretase activation. We demonstrate that zaragozic acid, a potent inhibitor of squalene synthase which blocks cholesterol synthesis but allows synthesis of isoprenoids, also stimulates alpha-secretase activity. Treatment of human n…
Intrinsic transverse momentum distribution of jet constituents in p-Pb collisions at ALICE
2014
The integral part of the URHIC program is also to study the pp and p–A collision in order to understand the “reference” (unmodified) particle production (in pp) and the “cold” nuclear phenomena in p–A. The main focus of this thesis is to study the parton shower evolution in p–Pb collisions in ALICE by analyzing jet fragmentation transverse momentum (j_{T} ). The analysis of j_{T} in p–Pb collisions, for which ALICE has a high quality data set, lays bases for later extension to pp and Pb–Pb data in order to study the induced gluon radiation. Additionally, the yields of \pi^0 meson were studied in Pb–Pb sqrt(s_{NN}) = 2.76 GeV collision. The \pi^0 analysis was followed for continuity of work …
Central functional response to the novel peptide cannabinoid, hemopressin.
2013
Hemopressin is the first peptide ligand to be described for the CB₁ cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood-brain barrier to both inhibit appetite and induce antinociception. Despite being highly effective, synthetic CB₁ inverse agonists are limited therapeutically due to unwanted, over dampening of central reward pathways. However, hemopressin appears to have its effect on appetite by affecting satiety rather than reward, suggesting an alternative mode of action which might avoid adverse side effects. Here, to resolve the neuronal circuitry mediating hemopressin's actions, we have combined blood-oxygen-level-dependent, pharmacological-ch…
Cannabinoid type 1 receptor modulates intestinal propulsion by an attenuation of intestinal motor responses within the myenteric part of the peristal…
2007
Cannabinoid-1 (CB1) receptor activation affects gastrointestinal propulsion in vivo. It was our aim to further characterize the involved myenteric mechanisms in vivo and in vitro. In CB1(-/-) mice and wild-type littermates we performed in vivo transit experiments by charcoal feeding and in vitro electrophysiological recordings in mouse small intestinal smooth muscle. Ascending neuronal contraction (ANC) following electrical field stimulation was studied in rat ileum in a partitioned organ bath separating the aboral stimulation site from the oral recording site. The knockout animals displayed an accelerated upper gastrointestinal transit compared to control animals. The CB1 receptor antagoni…
Differential effects of CB1 neutral antagonists and inverse agonists on gastrointestinal motility in mice
2010
Background Cannabinoid type 1 (CB1) receptors are involved in the regulation of gastrointestinal (GI) motility and secretion. Our aim was to characterize the roles of the CB1 receptor on GI motility and secretion in vitro and in vivo by using different classes of CB1 receptor antagonists. Methods Immunohistochemistry was used to examine the localization of CB1 receptor in the mouse ileum and colon. Organ bath experiments on mouse ileum and in vivo motility testing comprising upper GI transit, colonic expulsion, and whole gut transit were performed to characterize the effects of the inverse agonist/antagonist AM251 and the neutral antagonist AM4113. As a marker of secretory function we mea…
Passions animales
2021
In this article, questions concerning the relationship between semiotics and ethology will be discussed, starting from the idea of internaturality circulating in contemporary culture. After outlining the principles of a zoosemiotic 2.0, a case of animism present in the current press will be analysed, which speaks of the passions of apes as typically human passions.
On the carrier of inertia
2018
A change in momentum will inevitably perturb the all-embracing vacuum, whose reaction we understand as inertia. Since the vacuum's physical properties relate to light, we propose that the vacuum embodies photons, but in pairs without net electromagnetic fields. In this physical form the free space houses energy in balance with the energy of matter in the whole Universe. Likewise, we reason that a local gravitational potential is the vacuum in a local balance with energy that is bound to a body. Since a body couples to the same vacuum universally and locally, we understand that inertial and gravitational masses are identical. By the same token, we infer that gravity and electromagnetism shar…
Random allogeneic blood transfusion in pigs: characterisation of a novel experimental model.
2019
BackgroundOrgan cross-talk describes interactions between a primary affected organ and a secondarily injured remote organ, particularly in lung-brain interactions. A common theory is the systemic distribution of inflammatory mediators that are released by the affected organ and transferred through the bloodstream. The present study characterises the baseline immunogenic effects of a novel experimental model of random allogeneic blood transfusion in pigs designed to analyse the role of the bloodstream in organ cross-talk.MethodsAfter approval of the State and Institutional Animal Care Committee, 20 anesthetized pig were randomized in a donor and an acceptor (eachn = 8): the acceptor animals …