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showing 10 items of 3931 documents
The effect of treatment with omalizumab, an anti-IgE antibody, on asthma exacerbations and emergency medical visits in patients with severe persisten…
2005
Background: Patients with severe persistent asthma who are inadequately controlled despite treatment according to current asthma management guidelines have a significant unmet medical need. Such patients are at high risk of serious exacerbations and asthma-related mortality. Methods: Here, we pooled data from seven studies to determine the effect of omalizumab, an anti-immunoglobulin E (IgE) monoclonal antibody, on asthma exacerbations in patients with severe persistent asthma. Omalizumab was added to current asthma therapy and compared with placebo (in five double-blind studies) or with current asthma therapy alone (in two open-label studies). The studies included 4308 patients (2511 tre…
Cardiovascular diseases and apical periodontitis: association not always implies causality.
2020
Background: Several studies published in the last two decades have found an association between the prevalence of apical periodontitis (AP) or root canal treatment (RCT) and cardiovascular diseases (CVDs). However, the demonstration of association does not prove by itself the existence of a cause–effect relationship. Two diseases can appear as statistically related without any of them directly affecting the values of the other, resulting in a non-causal relationship. The aim of this narrative review is to summarize the current state of knowledge regarding the association between AP and CVDs, analysing it according to the Hill’s causality criteria. Materials and Methods: Epidemiological stud…
Influence of root canal instrumentation and obturation techniques on intra-operative pain during endodontic therapy.
2012
Objective: To analyse the influence of root canal instrumentation and obturation techniques on intra-operative pain experienced by patients during endodontic therapy. Method and Materials: A descriptive cross-sectional study was carried out in Ponferrada and Sevilla, Spain, including 80 patients (46 men and 34 women), with ages ranged from 10 to 74 years, randomly recruited. Patient gender and age, affected tooth, pulpal diagnosis, periapical status, previous NSAID or antibiotic (AB) treatment, and root canal instrumentation and obturation techniques were recorded. After root canal treatment (RCT), patients completed a 10-cm visual analogue scale (VAS) that ranked the level of pain. Results…
A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF.
2020
Abstract Research question Does clinical performance of personalized embryo transfer (PET) guided by endometrial receptivity analysis (ERA) differ from frozen embryo transfer (FET) or fresh embryo transfer in infertile patients undergoing IVF? Design Multicentre, open-label randomized controlled trial; 458 patients aged 37 years or younger undergoing IVF with blastocyst transfer at first appointment were randomized to PET guided by ERA, FET or fresh embryo transfer in 16 reproductive clinics. Results Clinical outcomes by intention-to-treat analysis were comparable, but cumulative pregnancy rate was significantly higher in the PET (93.6%) compared with FET (79.7%) (P = 0.0005) and fresh embr…
Deterministic and Random Vibration of Linear Systems with Singular Parameter Matrices and Fractional Derivative Terms
2021
Both time- and frequency-domain solution techniques are developed for determining the response of linear multi-degree-of-freedom systems exhibiting singular parameter matrices and endowed with derivative terms of noninteger orders modeled as rational numbers. This is done based on the Moore-Penrose matrix inverse theory, in conjunction with a state variable formulation and with a complex modal analysis treatment. It is worth noting that, for the class of systems considered herein, this treatment also yields decoupled governing equations, thus facilitating further their numerical solution. Next, a generalization of the standard frequency-domain input-output (excitation-response) relationship…
Scalable and Privacy-Preserving Admission Control for Smart Grids
2015
International audience; Energy demand and production need to be constantly matched in the power grid. The traditional paradigm to continuously adapt the production to the demand is challenged by the increasing penetration of more variable and less predictable energy sources, like solar photovoltaics and wind power. An alternative approach is the so called direct control of some inherently flexible electric loads to shape the demand. Direct control of deferrable loads presents analogies with flow admission control in telecommunication networks: a request for network resources (bandwidth or energy) can be delayed on the basis of the current network status in order to guarantee some performanc…
A novel hybrid model for air quality index forecasting based on two-phase decomposition technique and modified extreme learning machine.
2017
The randomness, non-stationarity and irregularity of air quality index (AQI) series bring the difficulty of AQI forecasting. To enhance forecast accuracy, a novel hybrid forecasting model combining two-phase decomposition technique and extreme learning machine (ELM) optimized by differential evolution (DE) algorithm is developed for AQI forecasting in this paper. In phase I, the complementary ensemble empirical mode decomposition (CEEMD) is utilized to decompose the AQI series into a set of intrinsic mode functions (IMFs) with different frequencies; in phase II, in order to further handle the high frequency IMFs which will increase the forecast difficulty, variational mode decomposition (VM…
Fatigue life under non-Gaussian random loading from various models
2004
Fatigue test results on the 10HNAP steel under constant amplitude and random loading with non-Gaussian probability distribution function, zero mean value and wide-band frequency spectrum have been used to compare the life time estimation of the models proposed by Bannantine, Fatemi–Socie, Socie, Wang–Brown, Morel and Łagoda–Macha. Except the Morel proposal which accumulates damage step by step with a proper ethodology, all the other models use a cycle counting method. The rainflow algorithm is used to extract cycles from random histories of damage parameters in time domain. In the last model, where a strain energy density parameter is employed, additionally spectral method is evaluated for …
A novel frequency domain method for predicting fatigue crack growth under wide band random loading
2007
This work deals with the evaluation of the fatigue crack growth rate of structural components subjected to uniaxial Gaussian stationary wide band random loading. In detail, a new frequency domain method that allows the user to estimate the expected crack growth rate directly from the PSD data is proposed. Using a stochastic mean function properly, introduced and described by simple closed form relationships implemented by systematic numerical simulations of a high number of wide band random processes, the proposed method permits to avoid the onerous time domain simulations and provides in general crack growth rate predictions in a good accordance with the so-called time domain method. Pract…
Memory irradiation measurements for the European SMART-1 spacecraft
2005
Three different types of memory circuits, that are intended to be used on board of the European satellite SMART-1, have been radiation hardness tested according to ESA's specification. Since the satellite is equipped with an electric propulsion engine, the spacecraft will be exposed to radiation during a long time when passing the radiation belt of the Earth. A standard DRAM circuit from SAMSUNG will serve as building block of the mass memory of SMART-1, and has been tested for total dose and proton induced single event upset (SEU). The DRAM memory showed surprisingly good resistance against radiation. The proton SEU cross sections for the radiation tolerant SRAM and FIFO circuits have also…