Search results for "Random"
showing 10 items of 3931 documents
Is there any place for PD-1/CTLA-4 inhibitors combination in the first-line treatment of advanced NSCLC?—A trial-level meta-analysis in PD-L1 selecte…
2021
BACKGROUND: The advent of immuno-oncology (IO) represented a breakthrough in non-small cell lung cancer (NSCLC) therapy over the last few years. However, establishing the optimal therapeutic options among programmed death-ligand 1 (PD-L1) selected subgroups still addresses an unmet need in the clinical setting. METHODS: We performed a systematic review and finally included eleven first-line randomized controlled trials to compare efficacy and safety outcomes among first-line IO treatment strategies versus standard platinum-based chemotherapy (CT) according to PD-L1 expression level (<1%, 1–49%, ≥50%). Pooled hazard ratios (HRs) and risk ratios (RRs) for progression-free survival (PFS), over…
Osteonecrosis of the Jaw in Myeloma Patients Receiving Denosumab or Zoledronic Acid. A Commentary of the Pivotal Trial by Raje et al. Published on La…
2018
The recent randomized trial, published by Raje et al., on Lancet Oncology is potentially practice changing. It proposes that denosumab is a valid alternative to zoledronic acid in the treatment of myeloma patients. However, several points need further data and more details, such as information on incidence, diagnosis, and follow-up of osteonecrosis of the jaw (ONJ) cases, observed among treated patients. Adopted definition to adjudicate ONJ cases, type of registration of potential ONJ cases, length of observation are possible causes of potential underestimation of ONJ incidence in their study. Future updated evaluations with longer follow-up, and including actuarial estimation, are required…
Nonlinear Modeling of DC/DC Converters Using the Hammerstein's Approach
2007
This paper deals with the modelling of highly nonlinear switching power-electronics converters using black-box identification methods. The duty cycle and the output voltage are chosen, respectively, as the input and the output of the model. A nonlinear Hammerstein-type mathematical model, consisting of a static nonlinearity and a linear time-invariant model, is considered in order to cope with the well-known limitations of the more common small-signal models, i.e. the entity of the variations of the variables around a well-defined steady-state operating point and the incorrect reproduction of the steady-state behavior corresponding to input step variations from the above steady-state operat…
All-optical measurements of background, amplitude, and timing jitters for high speed pulse trains or PRBS sequences using autocorrelation function
2008
International audience; We present a simple method for all-optical measurements of background, amplitude, and timing jitters of ultra high speed pulse trains or PRBS sequences using the jitter dependence of the intercorrelation-peak shape. This method is numerically and experimentally demonstrated on a 42.66 Gbit/s PRBS sequence and then applied to measure the jitter growths occurring during the propagation of a 160-GHz pulse train in a classical SMF/DCF dispersion map.
Polarization modulation instability in a Manakov fiber system
2015
International audience; The Manakov model is the simplest multicomponent model of nonlinear wave theory: It describes elementary stable soliton propagation and multisoliton solutions, and it applies to nonlinear optics, hydrodynamics, and Bose-Einstein condensates. It is also of fundamental interest as an asymptotic model in the context of the widely used wavelength-division-multiplexed optical fiber transmission systems. However, although its physical relevance was confirmed by the experimental observation of Manakov (vector) solitons in a planar waveguide in 1996, there have in fact been no quantitative experiments confirming its validity for nonlinear dynamics other than soliton formatio…
Random bit generation through polarization chaos in nonlinear optical fibers
2017
Nowadays, cryptographic applications are becoming of paramount importance in order to guarantee ultimately secure communications. Performances of classical and quantum key distribution and encryption algorithms are strongly dependent on the used Random Number Generator (RNG). A good RNG must produce unpredictable, unreproducible and unbiased sequences of numbers. For this reason, many true random number generators relying on chaotic physical phenomena, such as chaotic oscillations of high-bandwidth lasers [1, 2] or polarization chaos from a VCSEL diode [3], have been developed. In this work, we propose a RNG implementation based on a different physical mechanism than the ones previously use…
Optimal tuning of tuned liquid column damper systems in random vibration by means of an approximate formulation
2014
Passive control devices are often added to slender and flexible systems in order to increase their structural safety. Several types of devices have been proposed in order to reduce the dynamic responses of different kind of structural systems. Among them, the tuned liquid column damper (TLCD) proved to be very effective in reducing vibration of various type of structures by means of a combined action which involves the motion of the liquid mass within the tube. The restoring force, in particular, is produced by the force of gravity acting on the liquid and the damping effect is generated by the hydrodynamic head losses that arise during the motion of the liquid inside the TLCD. Since the in…
Optimization of Data Harvesters Deployment in an Urban Areas for an Emergency Scenario
2013
International audience; Since its appearance in the VANETs research community, data collection where vehicles have to explore an area and collect various local data, brings various issues and challenges. Some architectures were proposed to meet data collection requirements. They can be classified into two categories: Decentralized and Centralized self-organizing where different components and techniques are used depending on the application type. In this paper, we treat time-constrained applications in the context of search and rescue missions. For this reason, we propose a centralized architecture where a central unit plans and manages a set of vehicles namely harvesters to get a clear ove…
Spectral properties of random non-self-adjoint operators
2015
In this thesis we are interested in the spectral properties of random non-self-adjoint operators. Weare going to consider primarily the case of small random perturbations of the following two types of operators: 1. a class of non-self-adjoint h-differential operators Ph, introduced by M. Hager [32], in the semiclassical limit (h→0); 2. large Jordan block matrices as the dimension of the matrix gets large (N→∞). In case 1 we are going to consider the operator Ph subject to small Gaussian random perturbations. We let the perturbation coupling constant δ be e (-1/Ch) ≤ δ ⩽ h(k), for constants C, k > 0 suitably large. Let ∑ be the closure of the range of the principal symbol. Previous results o…
Effect of Oral Beta-Hydroxy-Beta-Methylbutyrate (HMB) Supplementation on Physical Performance in Healthy Old Women Over 65 Years: An Open Label Rando…
2015
Although older people are particularly liable to sarcopenia, limited research is available on beta-hydroxy-beta-methylbutyrate (HMB) supplementation in this population, particularly in healthy subjects. In this parallel-group, randomized, controlled, open-label trial, we aimed to evaluate whether an oral supplement containing 1.5 g of calcium HMB for 8 weeks could improve physical performance and muscle strength parameters in a group of community-dwelling healthy older women. Eighty healthy women attending a twice-weekly mild fitness program were divided into two equal groups of 40, and 32 of the treated women and 33 control completed the study. We considered a change in the Short Physical …