Search results for "Randomized Controlled Trial"
showing 10 items of 2199 documents
Eminence, or rather eloquence, or rather economy-based medicine?
2004
Survival Rate and Prosthetic and Sinus Complications of Zygomatic Dental Implants for the Rehabilitation of the Atrophic Edentulous Maxilla: A System…
2021
Simple Summary Zygomatic dental implants have been proposed as an alternative to atrophic total edentulous maxillae rehabilitation with the necessity of bone grafting procedures. However, surgical, prosthetic, and maxillary sinus complications have been associated with this surgical procedure. Therefore, it is necessary to produce a systematic review and meta-analysis that provides evidence associated with the prognosis when using zygomatic dental implants as an alternative to atrophic total edentulous maxillae rehabilitation. Abstract The aim of this systematic review and meta-analysis was to analyze and compare the survival rate and prosthetic and sinus complications of zygomatic dental i…
A Randomized Controlled Trial Comparing Inhaled Isoflurane Via the Anaesthetic Conserving Device (Sedaconda <sup>®</sup> ACD) with Propof…
2021
Background: Small studies indicate that isoflurane may be useful for sedation during invasive ventilation of ICU patients. There are no published large prospective efficacy trials. Methods: This phase 3, non-inferiority trial evaluated the efficacy and safety of ≤54 hours of isoflurane via the anaesthetic conserving device (ACD) compared with propofol in invasively ventilated ICU patients (30-day follow-up). Primary endpoint was percentage of time in Richmond Agitation–Sedation Scale (RASS) range –1 to –4; the predefined non-inferiority margin was 15% below the propofol mean. Secondary endpoints: opioid requirements, spontaneous breathing during sedation, time to wake-up and extubation, adv…
Supportive und adjunktive Therapiemaßnahmen bei akutem Lungenversagen
2008
Various supportive and adjunctive therapies to conventional mechanical ventilation have been evaluated in patients with acute lung injury and acute respiratory distress syndrome (e.g. nitric oxide, prone position, surfactant, glucocorticoids). Although some investigations have shown promising improvements in oxygenation and physiological variables, large randomized trials of adjunctive and supportive therapies showed no impact on survival.
How and for whom does a positive affect intervention work in fibromyalgia: An analysis of mediators and moderators.
2019
Objectives: Psychological interventions designed to enhance positive affect are promising ways to promote adaptive functioning in people with chronic pain. However, few studies have addressed the efficacy of positive affect interventions in chronic pain populations and examined which patients can benefit more from them. The aim of the present study was to identify mediators and moderators of the best possible self intervention (BPS) in fibromyalgia patients.Methods: We used data from a previous randomized controlled trial that examined changes in pain interference, depression, self‐efficacy and quality of life after the BPS intervention.Results: Mediation analyses showed that depression med…
Aerobic fitness mediates the intervention effects of a school-based physical activity intervention on academic performance. The school in Motion stud…
2021
Highlights • Physical activity is associated with increased aerobic fitness and academic performance. • Little is known on mechanism of physical activity effects on academic performance. • We performed a cluster randomized controlled trial. • Aerobic fitness mediated the intervention effect on academic performance. • Activity increasing aerobic fitness is a strategy to improve academic performance.
Mechanisms of Smartphone Apps for Cigarette Smoking Cessation: Results of a Serial Mediation Model From the iCanQuit Randomized Trial
2021
Background Engagement with digital interventions is a well-known predictor of treatment outcomes, but this knowledge has had limited actionable value. Instead, learning why engagement with digital interventions impact treatment outcomes can lead to targeted improvements in their efficacy. Objective This study aimed to test a serial mediation model of an Acceptance and Commitment Therapy (ACT) smartphone intervention for smoking cessation. Methods In this randomized controlled trial, participants (N=2415) from 50 US states were assigned to the ACT-based smartphone intervention (iCanQuit) or comparison smartphone intervention (QuitGuide). Their engagement with the apps (primary measure: numb…
Safety self-efficacy and internal locus of control as mediators of safety motivation – Randomized controlled trial (RCT) study
2019
Abstract Behavioral factors play a fundamental role in preventing occupational injuries and accidents. Previous studies have shown that engagement in safety behavior is influenced by workers’ safety motivation. However, understanding of the cognitive factors that contribute to safety motivation is lacking. In this study, we examine internal safety locus of control and safety self-efficacy as mediators of the effects of a safety intervention on safety motivation. In 2016, 464 students from eight vocational schools participated in a school-based cluster randomized, controlled intervention study conducted in Finland. In the multiple mediation model investigated using structural equation modeli…
Anxiety and the severity of Tension-Type Headache mediate the relation between headache presenteeism and workers’ productivity
2018
The primary objective of this study was to explore the mechanisms and conditions whereby Tension-Type Headache (TTH) presenteeism relates to health-related loss of productivity as a result of both reduced physical and mental health. To this end, Structural Equation Modeling (SEM) was used to conduct a secondary data analysis of a randomized clinical trial involving 78 Tension-type Headache (TTH) patients. The results showed that TTH presenteeism did not directly relate to health-related loss of productivity, either due to physical, or mental health problems. However, through anxiety-state, TTH presenteeism decreased patients' productivity, as consequence of reduced physical and mental healt…
2019
Given the documented decline in levels of physical activity in early adolescence, promoting physical activity in young people is a priority for health promotion. School physical education (PE) is an important existing network in which participation in physical activity beyond school can be promoted to the captive young people. The objective of current article is to present the protocol for a PE teacher-delivered theory-based trial to promote secondary school students’ participation in physical activity out-of-school contexts. The intervention will be guided by the trans-contextual model explaining the processes by which PE teachers’ support for autonomous motivation in the classroom promote…