Search results for "Randomized"
showing 10 items of 2323 documents
Economic Impact of 'Third-Wave' Cognitive Behavioral Therapies:A Systematic Review and Quality Assessment of Economic Evaluations in Randomized Contr…
2018
The term third-wave cognitive behavioral therapy (CBT) encompasses new forms of CBT that both extend and innovate within CBT. Most third-wave therapies have been subject to randomized controlled trials (RCTs) focused on clinical effectiveness; however, the number and quality of economic evaluations in these RCTs has been unknown and may be few. Evidence about efficiency of these therapies may help support decisions on efficient allocation of resources in health policies. The main aim of this study was to systematically review the economic impact of third-wave therapies in the treatment of patients with physical or mental conditions. We conducted a systematic literature search in PubMed, Psy…
Four-Year Study on the Bio-Agronomic Response of Biotypes of Capparis spinosa L. on the Island of Linosa (Italy)
2021
The caper plant is widespread in Sicily (Italy) both wild in natural habitats and as specialized crops, showing considerable morphological variation. However, although contributing to a thriving market, innovation in caper cropping is low. The aim of the study was to evaluate agronomic and production behavior of some biotypes of Capparis spinosa L. subsp. rupestris, identified on the Island of Linosa (Italy) for growing purposes. Two years and seven biotypes of the species were tested in a randomized complete block design. The main morphological and production parameters were determined. Phenological stages were also observed. Analysis of variance showed high variability between the biotype…
Smartphone Apps for the Treatment of Mental Disorders: Systematic Review
2020
Background Smartphone apps are an increasingly popular means for delivering psychological interventions to patients suffering from a mental disorder. In line with this popularity, there is a need to analyze and summarize the state of the art, both from a psychological and technical perspective. Objective This study aimed to systematically review the literature on the use of smartphones for psychological interventions. Our systematic review has the following objectives: (1) analyze the coverage of mental disorders in research articles per year; (2) study the types of assessment in research articles per mental disorder per year; (3) map the use of advanced technical features, such as sensors…
Extreme minimal learning machine: Ridge regression with distance-based basis
2019
The extreme learning machine (ELM) and the minimal learning machine (MLM) are nonlinear and scalable machine learning techniques with a randomly generated basis. Both techniques start with a step in which a matrix of weights for the linear combination of the basis is recovered. In the MLM, the feature mapping in this step corresponds to distance calculations between the training data and a set of reference points, whereas in the ELM, a transformation using a radial or sigmoidal activation function is commonly used. Computation of the model output, for prediction or classification purposes, is straightforward with the ELM after the first step. In the original MLM, one needs to solve an addit…
Do Randomized Algorithms Improve the Efficiency of Minimal Learning Machine?
2020
Minimal Learning Machine (MLM) is a recently popularized supervised learning method, which is composed of distance-regression and multilateration steps. The computational complexity of MLM is dominated by the solution of an ordinary least-squares problem. Several different solvers can be applied to the resulting linear problem. In this paper, a thorough comparison of possible and recently proposed, especially randomized, algorithms is carried out for this problem with a representative set of regression datasets. In addition, we compare MLM with shallow and deep feedforward neural network models and study the effects of the number of observations and the number of features with a special dat…
Variable neighborhood descent for the incremental graph drawing
2017
Abstract Graphs are used to represent reality in several areas of knowledge. Drawings of graphs have many applications, from project scheduling to software diagrams. The main quality desired for drawings of graphs is readability, and crossing reduction is a fundamental aesthetic criterion for a good representation of a graph. In this paper we target the edge crossing reduction in the context of incremental graph drawing, in which we want to preserve the layout of a graph over successive drawings. We propose a hybrid method based on the GRASP (Greedy Randomized Adaptive Search Procedure) and VND (Variable Neighborhood Descent) methodologies and compare it with previous methods via simulation.
Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease
2017
Background: Experimental and clinical data suggest that reducing inflammation without affecting lipid levels may reduce the risk of cardiovascular disease. Yet, the inflammatory hypothesis of atherothrombosis has remained unproved. Methods: We conducted a randomized, double-blind trial of canakinumab, a therapeutic monoclonal antibody targeting interleukin-1β, involving 10,061 patients with previous myocardial infarction and a high-sensitivity C-reactive protein level of 2 mg or more per liter. The trial compared three doses of canakinumab (50 mg, 150 mg, and 300 mg, administered subcutaneously every 3 months) with placebo. The primary efficacy end point was nonfatal myocardial infarction, …
Implant Abutment Cleaning by Plasma of Argon: 5-Year Follow-Up of a Randomized Controlled Trial.
2015
Contamination of implant abutments could potentially influence the peri-implant tissue inflammatory response. The aim of the present study is to assess the radiographic bone changes around customized, platform-switched abutments placed according to the "one-abutment-one-time" protocol, with and without plasma of argon cleaning treatment.Thirty healthy patients with thin gingival biotype (1 mm) and history of periodontal disease received one maxillary implant each. Immediately before abutment connection, patients were randomly assigned to control group (cleaning protocol by steaming) or test group (plasma of argon treatment). Outcome measures were: 1) success rate of implants and prostheses;…
Antimicrobial photodynamic therapy using diode laser activated indocyanine green as an adjunct in the treatment of chronic periodontitis: A randomize…
2016
Abstract Introduction Clinical studies have shown the usefulness of antimicrobial photodynamic therapy (aPDT) as an adjunctive in periodontal therapy. These studies did not utilize indocyanine green (ICG) as a recently introduced photosensitizer. The aim of this study was to perform a full-mouth double-blind randomized controlled clinical study to test the efficacy of adjunctive aPDT with ICG compared with scaling and root planing (SRP) alone in chronic periodontitis treatment. Materials and methods Fifty patients were selected for this study. All patients received SRP. Then, each patient was randomly assigned to either the test group (aPDT + SRP) or the control group (SRP). aPDT was perfor…
Radiotherapy for the treatment of solitary plasmacytoma: 7-year outcomes by a mono-institutional experience.
2020
Objectives: Solitary plasmacytoma (SP) is characterized by a single mass of clonal plasma cells. Definitive RT can result in long-term local control of the SP. Due to the small number of patients and narrow range of doses, phase III randomized trials are lacking. The aim of this study is to further support the potential use of RT for the treatment of SP. Methods: Clinical data of all patients treated for SP at our Institution between 1992 and 2018 were reviewed. A total of 42 consecutive patients were analyzed. Results: The median follow-up was 84.8 months. Radiation dose did not differ significantly as a function of sex, type of SP (solitary bone plasmacytoma or as extramedullary plasmacyt…