Search results for "Randomized"

showing 10 items of 2323 documents

Efficacy, safety and tolerability of aripiprazole in bipolar disorder: An updated systematic review and meta-analysis of randomized controlled trials

2017

Numerous studies have investigated aripiprazole as a treatment for bipolar disorder (BD). therefore we conducted this comprehensive meta-analysis to investigate the efficacy and safety profile of aripiprazole in treating BD. Two authors conducted systematic searches of PubMed and ScienceDirect from inception until May 14th, 2017. Randomized controlled trials (RCTs) of people with BD who received aripiprazole were included. A total of 20 RCTs met the eligibility criteria, including two which investigated the efficacy of aripiprazole versus haloperidol (aripiprazole = 340; haloperidol = 337), three which compared aripiprazole versus lithium (aripiprazole = 208; lithium = 212), and 15 with mul…

Transtorno Bipolarmedicine.medical_specialtyEfficacyBipolar disorderAripiprazolePlacebolaw.invention03 medical and health sciences0302 clinical medicineMaintenance therapyRandomized controlled trialAripiprazole; Bipolar disorder; Efficacy; Meta-analysis; Tolerability; Pharmacology; Biological PsychiatrylawInternal medicinemedicineHaloperidolHumansMeta-analysiBipolar disorderPsychiatryBiological PsychiatryRandomized Controlled Trials as TopicAripiprazole Bipolar disorder Efficacy Tolerability Meta-analysisPharmacologymedicine.diseaseTolerability030227 psychiatryMeta-analysisAripiprazolTolerabilityMeta-analysisAripiprazolePsychology030217 neurology & neurosurgeryAntipsychotic Agentsmedicine.drug
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A multicentre randomized controlled trial on trans-generational attention deficit/hyperactivity disorder (ADHD) in mothers and children (AIMAC): an e…

2018

Abstract. Objective: We examined predictors and moderators of treatment outcome in mothers and children diagnosed with ADHD in a large multicentre RCT. Method: In total, 144 mother-child dyads with ADHD were randomly assigned to either a maternal ADHD treatment (group psychotherapy and open methylphenidate medication, TG) or to a control treatment (individual counselling without psycho- or pharmacotherapy, CG). After maternal ADHD treatment, parent-child training (PCT) for all mother-child dyads was added. The final analysis set was based on 123 dyads with completed primary outcome assessments (TG: n = 67, CG: n = 56). The primary outcome was the change in each child’s externalizing sympto…

Treatment outcomeMotherslaw.inventionTrans generationalRandomized controlled trialChild of Impaired Parentslawmental disordersmedicineAttention deficit hyperactivity disorderHumans0501 psychology and cognitive sciencesChildbusiness.industry05 social sciencesGeneral MedicineExploratory analysismedicine.diseaseModerationPrognosis3. Good healthPsychiatry and Mental healthClinical PsychologyTreatment OutcomeAttention Deficit Disorder with HyperactivityPediatrics Perinatology and Child HealthMethylphenidatePsychotherapy GroupFemalebusiness050104 developmental & child psychologyClinical psychologyZeitschrift fur Kinder- und Jugendpsychiatrie und Psychotherapie
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Asymptomatic Carotid Lesion as a Marker of Future Cerebrovascular and Cardiovascular Events

2003

Tunica mediamedicine.medical_specialtyAngiotensin-Converting Enzyme InhibitorsComorbidityAsymptomaticText miningRisk FactorsCarotid lesionmedicineHumansCarotid StenosisRandomized Controlled Trials as TopicEndarterectomy Carotidbusiness.industryGeneral MedicineStrokeCarotid Arteriesmedicine.anatomical_structureCardiovascular DiseasesHypertensionSurgeryThickeningRadiologyHydroxymethylglutaryl-CoA Reductase Inhibitorsmedicine.symptomTunica IntimabusinessPlatelet Aggregation InhibitorsActa Chirurgica Belgica
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Perioperative morbidity and rate of upstaging after laparoscopic staging for patients with locally advanced cervical cancer: results of a prospective…

2015

Objective The International Federation of Gynecology and Obstetrics (FIGO) staging for cervical cancer is based on clinical examination. Previous studies have demonstrated significant upstaging with surgical staging. However, no randomized trial has ever shown a survival benefit when radiation combined with chemoradiation (RCTX) is modified according to surgical staging. The objective of the study was to evaluate the feasibility and outcomes of surgical staging prior to radical RCTX treatment among patients with locally advanced cervical cancer in the setting of a larger, prospective, randomized study (the Uterus-11 study of the German Gynecologic Oncology Group). Study Design Between 2009 …

Uterine Cervical Neoplasmmedicine.medical_treatmentBrachytherapyUterine Cervical NeoplasmsCarcinoma AdenosquamouAntineoplastic AgentPostoperative ComplicationsLaparotomyrandomized triallocally advanced cervical cancerLaparoscopyCervical cancermedicine.diagnostic_testMedicine (all)Lymph NodeObstetrics and GynecologyChemoradiotherapyMiddle Agedlaparoscopic stagingTreatment OutcomeCarcinoma Squamous CellFemaleoperative morbidityHumanAdultmedicine.medical_specialtyPelviBrachytherapyAntineoplastic AgentsGynecologic oncologyAdenocarcinomaPelvisCarcinoma AdenosquamousYoung AdultmedicineHumansExternal beam radiotherapyAgedNeoplasm StagingRadiotherapybusiness.industryPostoperative complicationPerioperativemedicine.diseaseSurgeryFeasibility StudieFeasibility StudiesLymph Node ExcisionLaparoscopyPostoperative ComplicationLymph NodesCisplatinbusinessAmerican journal of obstetrics and gynecology
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Effectiveness of pre-anaesthetic assessment clinic: a systematic review of randomised and non-randomised prospective controlled studies

2022

ObjectivesThe aim of this systematic review was to examine the effectiveness of pre-anaesthesia assessment clinics (PACs) in improving the quality and safety of perioperative patient care.DesignSystematic review.Data sourcesThe electronic databases CINAHL Plus with Full Text (EBSCOhost), Medline and Embase (OvidSP) were systematically searched on 11 September 2018 and updated on 3 February 2020 and 4 February 2021.Eligibility criteriaThe inclusion criteria for this study were studies published in English or Scandinavian language and scientific original research that included randomised or non-randomised prospective controlled studies. Additionally, studies that reported the outcomes from a …

VDP::Medisinske Fag: 700::Helsefag: 800HumansAnesthesiaVDP::Medisinske Fag: 700Prospective StudiesGeneral MedicineLength of StayAnestheticsChecklistRandomized Controlled Trials as Topic
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Risk of Death Associated With Intravitreal Anti-Vascular Endothelial Growth Factor Therapy: A Systematic Review and Meta-analysis.

2020

Importance Although intravitreal anti–vascular endothelial growth factor (VEGF) treatment represents the first-line therapy for many retinal diseases, the issue of their systemic safety is debatable. Objectives To assess whether intravitreal anti-VEGF therapy might be associated with increased risk of mortality and which variables are associated with the increase. Data Sources PubMed, MEDLINE, and Embase databases, the Cochrane Library, and ClinicalTrials.gov were systematically searched from inception to May 6, 2019. Study Selection Randomized clinical trials comparing intravitreal anti-VEGF treatment with control groups and with follow-up of at least 6 months were selected. Data Extractio…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyDatabases FactualMEDLINEAngiogenesis InhibitorsCochrane LibraryMacular Edemalaw.inventionRandomized controlled triallawFrequentist inferenceInternal medicineCause of DeathRetinal Vein OcclusionMedicineHumansanti-VEGF therapyrisk of mortality anti-vascular endothelial growth factor mortalityCause of deathOriginal InvestigationRandomized Controlled Trials as TopicDiabetic Retinopathybusiness.industryMortality rateOdds ratioChoroidal NeovascularizationOphthalmologyMeta-analysisIntravitreal InjectionsWet Macular DegenerationbusinessJAMA ophthalmology
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POOLED ESTIMATES OF INCIDENCE OF ENDOPHTHALMITIS AFTER INTRAVITREAL INJECTION OF ANTI-VASCULAR ENDOTHELIAL GROWTH FACTOR AGENTS WITH AND WITHOUT TOPI…

2017

Purpose: To assess the effect of topical antibiotic prophylaxis on postoperative endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents.Methods: A systematic literature search was performed from inception to March 2016 using PubMed, Medline, Web of Science, Embase, and the Cochrane Library, to identify articles that reported cases of endophthalmitis after intravitreal injection of anti-vascular endothelial growth factor agents. We used a pooled analysis to estimate the incidence of cases of endophthalmitis who developed after injections performed with and without topical antibiotic prophylaxis. We used regression analysis to explore the effects of stu…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyEye InfectionsVisual AcuityAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection;Angiogenesis InhibitorsCochrane LibraryGlobal HealthEye Infections Bacteriallaw.invention03 medical and health sciencestopical antibiotic prophylaxis; postoperative endophthalmitis; anti–vascular endothelial growth factor agents; intravitreal injectionpostoperative endophthalmitis0302 clinical medicineEndophthalmitisRandomized controlled triallawtopical antibiotic prophylaxisanti–vascular endothelial growth factor agentsInternal medicinemedicineantibiotic prophylaxiHumansanti-vascular endothelial growth factor030212 general & internal medicineAntibiotic prophylaxisProspective cohort studyAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection; Angiogenesis Inhibitors; Anti-Bacterial Agents; Endophthalmitis; Eye Infections Bacterial; Global Health; Humans; Intravitreal Injections; Vascular Endothelial Growth Factor A; Antibiotic Prophylaxis; Visual AcuityEndophthalmitisbusiness.industryIncidence (epidemiology)Bacterialintravitreal injectionRetrospective cohort studyGeneral MedicineEye infectionAntibiotic Prophylaxismedicine.diseaseAntibiotic prophylaxis; Anti–vascular endothelial growth factor; Endophthalmitis; Intravitreal injection; Angiogenesis Inhibitors; Anti-Bacterial Agents; Endophthalmitis; Eye Infections; Bacterial; Global Health; Humans; Intravitreal Injections; Vascular Endothelial Growth Factor A; Antibiotic Prophylaxis; Visual AcuitySurgeryAnti-Bacterial AgentsOphthalmologyendophthalmitiIntravitreal Injections030221 ophthalmology & optometryAnti–vascular endothelial growth factorbusiness
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Treat and extend versus fixed regimen in neovascular age related macular degeneration: A systematic review and meta-analysis

2020

Purpose: To compare efficacy of treat and extend (T&E) versus fixed regimen treatment protocols in neovascular age-related macular degeneration (nAMD). Methods: Randomized clinical trials (RCTs) comparing T&E versus fixed regimen protocols for nAMD were systematically searched. Primary outcome was to compare the mean best corrected visual acuity (BCVA) change in T&E regimen versus fixed regimen. Secondary outcomes were change in the mean optical coherence tomography (OCT) central retinal thickness (CRT) and mean number of injections. Standardized mean difference (SMD) along with 95% confidence intervals (CIs) were calculated. Random-effect models were used for meta-analyses. Res…

Vascular Endothelial Growth Factor Amedicine.medical_specialtyretinaretinal pathology/researchVisual AcuityAngiogenesis InhibitorsTreat and extendlaw.inventionMacular DegenerationRandomized controlled trialClinical Protocolsretina – medical therapieslawInternal medicineAge relatedRanibizumabMedicineHumansbusiness.industryAge-related macular degenerationGeneral MedicineMacular degenerationpediatric ophthalmologyretina – medical therapiemedicine.diseaseOphthalmologyRegimenTreatment OutcomeMeta-analysisvitreous/retinal diseaseIntravitreal InjectionsWet Macular DegenerationPediatric ophthalmologypharmacologybusinessTomography Optical CoherenceAge-related macular degeneration; pediatric ophthalmology; pharmacology; retina; retina – medical therapies; retinal pathology/research; vitreous/retinal disease
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Vasopressor-Sparing Strategies in Patients with Shock: A Scoping-Review and an Evidence-Based Strategy Proposition

2021

Despite the abundant literature on vasopressor therapy, few studies have focused on vasopressor-sparing strategies in patients with shock. We performed a scoping-review of the published studies evaluating vasopressor-sparing strategies by analyzing the results from randomized controlled trials conducted in patients with shock, with a focus on vasopressor doses and/or duration reduction. We analyzed 143 studies, mainly performed in septic shock. Our analysis demonstrated that several pharmacological and non-pharmacological strategies are associated with a decrease in the duration of vasopressor therapy. These strategies are as follows: implementing a weaning strategy, vasopressin use, system…

Vasopressinmedicine.medical_specialtyendocrine systemEvidence-based practicemedicine.medical_treatmentReviewvasopressorshocklaw.inventionnorepinephrineNorepinephrine (medication)Sepsissepsis03 medical and health sciences0302 clinical medicineRandomized controlled triallawmedicineRenal replacement therapyIntensive care medicinebusiness.industrySeptic shockweaningR030208 emergency & critical care medicineGeneral Medicinemedicine.disease030228 respiratory systemShock (circulatory)Medicinemedicine.symptombusinesshormones hormone substitutes and hormone antagonistsmedicine.drugJournal of Clinical Medicine
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Periodontal treatment on patients with cardiovascular disease : systematic review and meta-analysis

2018

Podeu consultar la versió en castellà del document a: http://hdl.handle.net/2445/153580

Very low-density lipoproteinmedicine.medical_specialtyMalalties periodontalsDisease030204 cardiovascular system & hematologylaw.invention03 medical and health scienceschemistry.chemical_compound0302 clinical medicineRandomized controlled triallawInternal medicinemedicineHumansGeneral DentistryPeriodontal DiseasesOral Medicine and PathologyMalalties cardiovascularsCholesterolbusiness.industryResearch030206 dentistryAtherosclerosis:CIENCIAS MÉDICAS [UNESCO]Confidence intervalClinical trialCardiovascular diseasesOtorhinolaryngologychemistryCardiovascular DiseasesMeta-analysisUNESCO::CIENCIAS MÉDICASEtiologySurgeryPeriodontal diseasebusinessAterosclerosi
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