Search results for "Ranula"

A model integrating the cerebellar granule neuron excitability and calcium signaling pathways

2004

Abstract The activation of various intracellular biochemical pathways is influenced by the electroresponsiveness of the neuron. There exists a close and constant co-operation between the membrane-bound cellular functions and intracellular signaling. This work aims at integrating the biophysical and biochemical data available for the cultured cerebellar granule neuron. The models of calcium-protein kinase C signaling pathways are combined with the model of the granule neuron excitability. The latter model can be used to provide the realistic stimulus for the signaling pathway models. The integrated model makes it possible to explore the participation of intracellular mechanisms in the neuron…

Does relevance matter to data mining research?

2008

Data mining (DM) and knowledge discovery are intelligent tools that help to accumulate and process data and make use of it. We review several existing frameworks for DM research that originate from different paradigms. These DM frameworks mainly address various DM algorithms for the different steps of the DM process. Recent research has shown that many real-world problems require integration of several DM algorithms from different paradigms in order to produce a better solution elevating the importance of practice-oriented aspects also in DM research. In this chapter we strongly emphasize that DM research should also take into account the relevance of research, not only the rigor of it. Und…

Projekts: Uzņēmuma "Pape King" izveidošana

2016

Maģistra darba temats ir “Projekts: Uzņēmuma “Pape King” izveidošana” un tā mērķis ir bizness plāna izstrāde uzņēmuma dibināšanai, veicot tirgus izpēti un finanšu analīzi, kā arī pēc iegūtiem rezultātiem ieplānot uzņēmuma atbilstošo struktūru un tā darbības plānu atbilstoši iespējām izmantot ārējo finansējumu un risku novēršanas pasākumus. Maģistra darba ietvaros ir izstrādāts bizness plāns jaundibinātam uzņēmuma “Pape King”, tā komercdarbības forma ir izvēlēta sabiedrība ar ierobežotu atbildību ar sākotnējo kapitālu 500 000 eiro lielumā. Uzņēmumam būs 2 īpašnieki ar vienādu līdzdalību pamatkapitālā un lēmumu pieņemšanā. Uzņēmums tiks dibināts un atrādīsies Rēzeknē speciālajā ekonomiskajā z…

T Cell Large Granular Lymphocytic Leukemia in Association with Sjögren’s Syndrome

2009

T cell large granular lymphocytic (LGL) leukemia is a rare condition accounting for 2–3% of all mature lymphoid leukemias. Here, we present the case of a 73-year-old woman presenting with neutropenia and anemia (hemoglobin 9.9 g/dl). Hematological assessment revealed the presence of a T cell LGL leukemia. At the time of T cell LGL leukemia diagnosis, the patient developed xerophthalmia and xerostomia, and a diagnosis of Sjögren’s syndrome was made following salivary gland biopsy. The finding of large granular lymphocytes in the context of autoimmune disorders is well-known, though it often occurs with rheumatoid arthritis or in association with a positive autoantibody titer in the absence o…

Effect of imidazo[1,2-α]pyrimidine derivatives on leukocyte function

2001

Objective and Design: A series of six imidazo[1,2-α]pyrimidine (IP) derivatives were evaluated for their effects on leukocyte functions in vitro as well as on the inflammatory response induced by zymosan in the mouse air pouch.¶Materials and Subjects: Human neutrophils and murine peritoneal macrophages were used for in vitro assays. Mouse air pouch was performed in Swiss mice.¶Treatment: Test compounds were incubated with either human neutrophils or mouse peritoneal macrophages at concentrations not showing cytotoxic effects. For in vivo experiments, IPs were injected into the air pouch.¶Methods: Elastase and myeloperoxidase release, superoxide generation and LTB4 production were assayed in…

Bank-specific shocks and aggregate leverage: Empirical evidence from a panel of developed countries

2020

International audience; This paper investigates the link between shocks in the banking sector and aggregate leverage measured by the credit-to-GDP gap. Using a balanced panel of 15 countries for the period 1989–2016, we exploit the approach due to Gabaix (2011) and consider banking granular shocks as an indicator of banking distress. Using methods that account for potential endogeneity, we find that banking shocks Granger-cause aggregate leverage. In particular, banking shocks tend to increase the level of leverage and cause departures of the credit-to-GDP ratio from its long-term trend.

Effect of some hexahydroimidazo[1,2-c]pyrimidines in inflammatory responses involving leucocytes and macrophages.

2001

Abstract We have studied the effects of some hexahydroimidazo[1,2-c]pyrimidine derivatives (HIPs) on leucocyte functions in-vitro and we have assayed the anti-inflammatory activity of these compounds in two models of inflammation. All HIPs inhibited the human neutrophil degranulation process and superoxide generation at concentrations in the μM range. In mouse peritoneal macrophages stimulated with lipopolysaccharide, HIP-4 and HIP-5 inhibited nitrite production without affecting prostaglandin E2 (PGE2) accumulation. HIP-4 was also active in the zymosan-injected mouse air pouch model (at 100 nmol/pouch), with significant reductions in leucocyte migration and PGE2 and leukotriene B4 levels i…

2014

The lungs are a noted predilection site of acute, latent, and reactivated cytomegalovirus (CMV) infections. Interstitial pneumonia is the most dreaded manifestation of CMV disease in the immunocompromised host, whereas in the immunocompetent host lung-infiltrating CD8 T cells confine the infection in nodular inflammatory foci and prevent viral pathology. By using murine CMV infection as a model, we provide evidence for a critical role of mast cells (MC) in the recruitment of protective CD8 T cells to the lungs. Systemic infection triggered degranulation selectively in infected MC. The viral activation of MC was associated with a wave of CC chemokine ligand 5 (CCL5) in the serum of C57BL/6 m…

Keratinocyte-Derived Granulocyte-Macrophage Colony Stimulating Factor Accelerates Wound Healing: Stimulation of Keratinocyte Proliferation, Granulati…

2001

Chronic, nonhealing wounds represent a major clinical challenge to practically all disciplines in modern medicine including dermatology, oncology, surgery, and hematology. In skin wounds, granulocyte-macrophage colony stimulating factor (GM-CSF) is secreted by keratinocytes shortly after injury and mediates epidermal cell proliferation in an autocrine manner. Many other cells involved in wound healing including macrophages, lymphocytes, fibroblasts, endothelial cells, and dendritic cells synthesize GM-CSF and/or are targets of this cytokine. Therefore, GM-CSF is a pleiotropic cytokine evoking complex processes during wound repair. Despite this complexity and the scarcity of mechanistic unde…

IC3D Classification of Corneal Dystrophies—Edition 2

2015

To update the 2008 International Classification of Corneal Dystrophies (IC3D) incorporating new clinical, histopathologic, and genetic information.The IC3D reviewed worldwide peer-reviewed articles for new information on corneal dystrophies published between 2008 and 2014. Using this information, corneal dystrophy templates and anatomic classification were updated. New clinical, histopathologic, and confocal photographs were added.On the basis of revisiting the cellular origin of corneal dystrophy, a modified anatomic classification is proposed consisting of (1) epithelial and subepithelial dystrophies, (2) epithelial-stromal TGFBI dystrophies, (3) stromal dystrophies, and (4) endothelial d…