Search results for "Ranula"

Inhibition of phospholipase A2 activities and some inflammatory responses by the marine product ircinin

1996

The marine product ircinin has been tested for its effects on secretory and cytosolic phospholipase A2 (PLA2) activities in vitro as well as for inhibition of cellular functions in human neutrophils and inflammatory responses in mice. Ircinin inhibited Naja naja venom, human synovial recombinant, bee venom and zymosan-injected rat air pouch PLA2 with IC50 values in the microM range, similar to those of the known inhibitor scalaradial. On the other hand, ircinin was less active on cytosolic PLA2 from human monocytes and decreased potently the release of LTB4 in human neutrophils. This marine product affected weakly human neutrophil functions like superoxide generation and degranulation. In t…

Angiogenesis in Wounds Treated by Microdeformational Wound Therapy.

2011

BACKGROUND:: Mechanical forces play an important role in tissue neovascularization and are a constituent part of modern wound therapies. The mechanisms by which vacuum assisted closure (VAC) modulates wound angiogenesis are still largely unknown. OBJECTIVE:: To investigate how VAC treatment affects wound hypoxia and related profiles of angiogenic factors as well as to identify the anatomical characteristics of the resultant, newly formed vessels. METHODS:: Wound neovascularization was evaluated by morphometric analysis of CD31-stained wound cross-sections as well as by corrosion casting analysis. Wound hypoxia and mRNA expression of HIF-1α and associated angiogenic factors were evaluated by…

Pediatric oral ranula: clinical follow-up study of 57 cases

2010

Objective: To present 57 cases of oral ranula in children, analyzing the clinical characteristics, treatment and outcome of these lesions. Methods: The clinical histories of patients diagnosed with oral ranula, seen between 1998 and 2008 at the Oral and Maxillofacial Surgery Unit of a reference Children?s Hospital (0-14 years) were reviewed. All patients with clinical diagnosis of oral ranula were included. Results: Fifty-seven patients, 21 boys and 36 girls, with a mean age of 5.1 years were included in the study. Thirtytwo cases were located on the left side of the floor of the mouth. The lesion diameter varied between 1 and 3 cm in 27 cases, 22 were less than 1 cm, and 8 were larger than…

Nicotine-induced fibroblast growth factor-2 restores the age-related decline of precursor cell proliferation in the subventricular zone of rat brain.

2007

Precursor cell proliferation is present in the subventricular zone (SVZ) of the lateral ventricles and the subgranular zone (SGZ) of the dentate gyrus of the hippocampus of adult rat and persists during aging although at reduced levels. Previous studies have shown that acute intermittent nicotine treatment significantly increases fibroblast growth factor-2 (FGF-2) expression in several brain regions of aged rats. The aim of the present investigation was to test the hypothesis that nicotine-induced expression of FGF-2 may restore the age-related decline of precursor cell proliferation. It was first demonstrated that nicotine treatment increases both mRNA and protein FGF-2 in the SVZ of aged …

The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells?

1984

Pancreatic tissue obtained at subtotal pancreatectomy from 15 infants with persistent hypoglycaemia with hyperinsulinism, and autopsy specimens from 23 age-matched normoglycaemic controls, were studied with morphometric methods after immunocytochemical staining of the four main islet cell types (A, B, D and pancreatic polypeptide cells). In three cases, a focal lesion was detected by gross examination. Macroscopic or microscopic examination did not distinguish the 12 other cases from controls. As found previously, nesidioblastosis was not a specific feature of the pancreas in infantile hypoglycaemia, being observed in age-matched controls as well. In cases with hypoglycaemia the volume dens…

What is the frequency of floor of the mouth lesions? A descritive study of 4,016 cases.

2020

Background The aim of this study was to investigate the frequency of oral lesions in the floor of the mouth from representative oral pathology centres in Latin America. Material and Methods This study was conducted on biopsies obtained from January of 1978 to December of 2018 at nine Latin America oral and maxillofacial pathology centres. Gender, age and histopathological diagnosis were evaluated. Data were analysed using descriptive methods. Chi-square test was used for pairwise comparisons. Results From 114,893 samples, 4,016 lesions (3.49%) occurred in the floor of the mouth. Brazil showed 3,777 cases (94%), Mexico 182 cases (4.5%) and Argentina 57 cases (1.4%). Benign lesions represente…

Characterization of rubberized asphalt for railway sub-ballast. Improvements in the mix-design, performance features and rational methodology of HMA_…

2018

(STR) can be incorporated into asphalt mixtures in two different methods, which are referred to as the wet-dry process. The blending of recycled rubber (CRM) with asphalt has been used for years, and several manufacturing processes have been developed in Europe as well as in the USA. The use of a bituminous sub-ballast layer has been pointed out as an exciting alternative to the granular sub-ballast design traditionally applied in most railroad tracks. Frequently, unbound granular materials are replaced by bituminous sub-ballast that provide additional benefits to the subgrade protection. Much research has been conducted on finding other alternative material to be used as a modifier in asph…

CHARACTERIZATION OF RUBBERIZED ASPHALT FOR RAILWAY SUB-BALLASTS

Tesi di dottorato sotto la supervisione del professore Gaetano di Mino del Dipartimento di Ingegneria Civile di Palermo), come borsista Marie-Curie all'interno del progetto SUPRITN 2013/2017. Il mio lavoro e la linea della ricerca riguarda i conglomerati bituminosi con granulato di gomma per lo strato di sub-ballast nelle linee ferroviarie. L’attività di ricerca comprende il mix-design dell’asfalto con aggiunta di gomma, la caratterizzazione e le prestazioni per la ferrovia in termini di comportamento meccanico e lo smorzamento delle vibrazioni. In particolare con l’avvento dell’alta velocità, diversi studi hanno evidenziato ottime caratteristiche fisico-meccaniche per ciò che riguarda il c…

Modified marsupialisation of a giant intraoral ranula: Case report

2016

La ránula intraoral es una enfermedad benigna seudoquística de extravasación que tiene su origen en las glándulas salivales sublinguales. Es una entidad poco prevalente. Es más frecuente en niños y adolescentes, con características clínicas propias que la diferencian de otras entidades de la boca. Su tratamiento es quirúrgico y varias técnicas han sido descritas en la literatura: marsupialización simple y modificada, enucleación de la lesión, extirpación de la glándula junto con enucleación de la ránula. Si bien la extirpación de la glándula junto con la enucleación de la lesión es el tratamiento definitivo radical y más aceptado, la marsupialización modificada puede ser útil como alternati…

On the coupling dynamics between thermally stressed beams and granular chains

2015

The in-situ measurement of thermal stress in slender beams, or long continuous welded rails, may prevent structural anomalies. With this aim, we investigated the coupling dynamics between a beam and the highly nonlinear solitary waves propagating along a straight granular chain in contact with the beam. We hypothesized that these waves can be used to measure the stress of thermally loaded structures, or to infer the neutral temperature, i.e., the temperature at which this stress is null. We studied numerically and experimentally the mechanical interaction of one and two straight chains of spherical particles in contact with a prismatic beam that is subjected to heat. The results show that c…