Search results for "Ratification"
showing 10 items of 234 documents
Seasonal variability of radiation tide in Gulf of Riga
2020
Diurnal oscillations of water level in Gulf of Riga are considered. It was found that there is distinct daily pattern of diurnal oscillations in certain seasons. The role of sea breeze, gravitational tides and atmospheric pressure gradient are analysed. The interference of the first two effects provide the dominant role in diurnal oscillations. The effect of gravitational tides is described both with sole tidal forcing and also in real case with atmospheric forcing and stratification. The yearly variation of the declination of the Sun and stratification leads to seasonal intensification of gravitational tides in Gulf of Riga. Correlation between gravitational tide of the Sun with its radiat…
Context matters-consensus molecular subtypes of colorectal cancer as biomarkers for clinical trials
2019
Abstract The Colorectal Cancer Subtyping Consortium identified four gene expression consensus molecular subtypes, CMS1 (immune), CMS2 (canonical), CMS3 (metabolic), and CMS4 (mesenchymal), using multiple microarray or RNA-sequencing datasets of primary tumor samples mainly from early stage colon cancer patients. Consequently, rectal tumors and stage IV tumors (possibly reflective of more aggressive disease) were underrepresented, and no chemo- and/or radiotherapy pretreated samples or metastatic lesions were included. In view of their possible effect on gene expression and consequently subtype classification, sample source and treatments received by the patients before collection must be ca…
Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma
2016
Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers. In total, 396 low- and high-risk primary tumors were analyzed, of which 87 were profiled using methyl-CpG-binding domain (MBD) sequencing for differential methylation analysis between prognostic patient groups. Subsequently, methylation-specific PCR (MSP) assays were developed for 78 top-ranking differentially methylated regions and tested on two independent cohorts of 132 and 177 samples, respectively. Further, a new statistical framework was used to identify a robust set of MSP assays of which the methylation score (i.e.…
Romanian Households Dealing with Precariousness: A life-course approach
2016
This paper addresses the main pathways through which households avoid slipping into poverty in Romania by employing a life-course approach. Recent researches on social stratification found that in every country we can delineate a particular social layer composed of households living just above the poverty threshold, whose members struggle to reach a more secure prosperity while facing constant threats of downward mobility. Drawing on recent precarious prosperity research, and based on in-depth interviews carried out in 2013 with 25 households situated in between poverty and prosperity from a Romanian city (Cluj-Napoca), we use a life-course approach in order to account for the main routes i…
Inequalities in educational opportunities in France: educational expansion, democratization or shifting barriers?
2000
International audience; This paper is concerned with inequalities in educational opportunities in France and presents data collected from cohorts born between 1919 and 1973, a period characterized by educational expansion. Data from large-scale representative French surveys were compiled in such a way as to make accurate historical and international comparisons possible. The paper argues that there has been a shift in social inequalities, from entry into collège (lower secondary school) to entry into lycée (upper secondary school leading to the baccalauréat). Finally, policy implications have been drawn from international comparisons of data on the reduction of social inequality. Cet articl…
Young people not in employment, education or training (NEET): the role of basic competencies
2021
A top priority for public policies at both national and European levels, young people who are not in employment, education or training (NEET) face a risk of exclusion that varies in intensity from country to country. While education level plays a central role in these situations, viewing them through the lens of basic competencies sharpens the focus. After all, the international data show that the same level of qualification does not guarantee the same level of competencies everywhere. How can these differences be explained? To what extent do these basic competencies protect young people from becoming not in employment, education or training regardless of their level of qualification?
Aortic valve stenosis: Treatments options in elderly high-risk patients
2016
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The role of travel motivations and social media use in consumer interactive behaviour: a uses and gratifications perspective
2020
This paper explores the influence of travel motivations and the gratification provided by social media in consumer stickiness to social media, intention to create user-generated content, and electronic word of mouth (eWOM) review adoption. The study follows a mixed-methods approach. First, a concept mapping study was undertaken to identify the main travel motivations and the gratifications provided by social media when consumers search for information on tourism destinations. A second study using structural equation modelling and SmartPLS 3.2.7 with a sample of 401 heavy users of social media showed the relationships between individual travel motivations and gratifications provided by socia…
Ethnic and Religious Conflicts in France
2011
International audience; This chapter presents a detailed analysis of current and historical interethnic relations in France. Kamiejski, De Oliveira, and Guimond apply several theories in exploration of the variables related to the development of the existent ethnic tensions in this region. Policy models are also evaluated and considered as means of engendering harmony in the future. Discussion of the most recent and largest immigrant group to France, the Maghrebians, reveals several factors associated with increasing tensions including the large degree of assumed difference in values, religion, and culture. The authors recognize that France has set the stage for positive interethnic relatio…
Unbiased Estimators and Multilevel Monte Carlo
2018
Multilevel Monte Carlo (MLMC) and unbiased estimators recently proposed by McLeish (Monte Carlo Methods Appl., 2011) and Rhee and Glynn (Oper. Res., 2015) are closely related. This connection is elaborated by presenting a new general class of unbiased estimators, which admits previous debiasing schemes as special cases. New lower variance estimators are proposed, which are stratified versions of earlier unbiased schemes. Under general conditions, essentially when MLMC admits the canonical square root Monte Carlo error rate, the proposed new schemes are shown to be asymptotically as efficient as MLMC, both in terms of variance and cost. The experiments demonstrate that the variance reduction…