Search results for "Reaction"
showing 10 items of 6134 documents
Osteogenic differentiation of periodontal fibroblasts is dependent on the strength of mechanical strain
2012
Abstract Objective During orthodontic therapy the correct strength of mechanical strain plays a key role for bone remodelling during tooth movement. Aim of this study was to investigate the osteogenic differentiation of human periodontal ligament fibroblasts (HPdLF) depending on the applied strength of mechanical strain compared to osteoblasts (HOB). Design HPdLF and HOB were loaded with different strengths (1%, 5% and 10%) of static mechanical strain (SMS) for 12 h in vitro. Viability was verified by MTT and apoptosis by TUNEL assay. Gene expression of cyclin D1, collagen type-1 (COL-I), alkaline phosphatase (ALP), osteocalcin, osteoprotegerin (OPG) and receptor activator of the NF-κB liga…
Arthralgia as an early extraintestinal symptom of Whipple's disease. Report of five cases.
1997
Five patients with Whipple's disease all suffered from arthralgia for a long time (15 years in one case) before developing gastrointestinal or other symptoms. In all patients, arthralgia was seronegative, and there was no evidence of joint destruction. Arthralgias were symmetric and migrating. Whipple's disease is part of the differential diagnosis of enteropathic arthralgia. Thereby, the polymerase chain reaction can be a helpful tool to prove Whipple's disease in difficult differential diagnosis.
Comparison between the directly measured achilles tendon force and the tendon force calculated from the ankle joint moment during vertical jumps.
1988
Summary The purpose of this study was to compare the relationship between the achilles tendon force and the tendon force estimated from the ankle joint moment (EATF) during vertical jump. A healthy male subject performed the following jumps on the force platform: (a) maximal vertical jump from a squat position without counter-movement; (b) maximal vertical jump from an erect standing position with a preliminary counter-movement; (c) repetitive submaximal hopping on the spot with preferred frequency. The achilles tendon force was measured directly with an implanted tendon transducer in all jumping conditions. In addition the joint moment obtained from the film and ground reaction force was u…
Consequences of Justifications of Assessments in French Expanded Audit Reports
2018
Since 2003, French auditors must disclose justifications of assessments (JOAs) in expanded audit reports. Like critical audit matters recently introduced in the US and key audit matters introduced by international standard setters, the purpose of JOAs is to enhance the informative value of audit reports. Based on French audit reports issued from 2002 to 2011, we analyze the impact of first-time implementation of JOAs, and the impact of new JOAs in subsequent years, on investors (measured by abnormal returns and abnormal trading volume) and on the audit (measured by audit report lag, abnormal accruals, and audit fees). For both first-time implementation of JOAs and new JOAs in subsequent yea…
Sequence analysis of the DRB1 promoter reveals limited polymorphism with no influence on gene expression.
2001
HLA-class II promoters contain a set of conserved regulatory regions necessary for constitutive and induced gene expression. For the HLA-DQB as well as for the DRB1 promoter sequence, polymorphisms with influence on gene expression have been reported. In contrast to these data we could show that there is very limited allele-specific polymorphism among the HLA-DRB1 promoter alleles. In a long range PCR we amplified a DNA sequence containing the promoter and the second exon of the DRB1 gene in one fragment. Nested PCR products of this PCR fragment for the promoter and for the second exon were analysed by DNA sequencing to allow the linkage of a promoter to its DR allele. Most investigated DRB…
Parathyroid hormone-related peptide and 8701-BC breast cancer cell growth and invasion in vitro: evidence for growth-inhibiting and invasion-promotin…
1995
It has been previously reported that 8701-BC cells, derived from a primary carcinoma of the breast, constitutively express parathyroid hormone-related peptide (PTHrP) gene and that N-terminal PTHrP immunoreactivity can be found in cell medium. Here we have firstly measured immunoreactive PTHrP in 8701-BC cell medium using antibodies raised against midregion and C-terminal fragments, and also demonstrated the expression of PTH/PTHrP receptor by 8701-BC cells. Secondly, we have examined the role, if any, elicited by diverse PTHrP domains on 8701-BC cell proliferation, and invasive behaviour in vitro related to production of extracellular proteolytic enzymes. Our data show that PTHrP [1-34], a…
Extracellular matrix regulation of PTHrP and PTH/PTHrP receptor in a human breast cancer cell line
1999
AbstractIt was previously reported that 8701-BC breast cancer cells express the gene for parathyroid hormone-related peptide (PTHrP) and its cognate receptor (PTHrP-R), and release immunoreactive PTHrP in the extracellular medium; it was also found that PTHrP, in turn, exerts a role on the proliferative and invasive behavior in vitro of the same cell line. On the other hand, evidence has been produced that adhesion of 8701-BC cells onto different collagen substrates influences in various ways a number of phenotypic expressions, such as cell growth, motility, invasion of reconstituted basement membrane and production of lytic enzymes of the extracellular matrix (ECM). In light of these previ…
Management of Statin Intolerance in 2018: Still More Questions Than Answers.
2018
Statin therapy is generally well tolerated and very effective in the prevention and treatment of cardiovascular disease, regardless of cholesterol levels; however, it can be associated with various adverse events (myalgia, myopathy, rhabdomyolysis, and diabetes mellitus, among others). Patients frequently discontinue statin therapy without medical advice because of perceived side effects and consequently increase their risk for cardiovascular events. In patients with statin intolerance, it may be advisable to change the dose, switch to a different statin, or try an alternate-day regimen. If intolerance is associated with all statins—even at the lowest dose—non-statin drugs and certain nutra…
Solar neutrino spectroscopy in Borexino
2018
International audience; In more than ten years of operation, Borexino has performed a precision measurement of the solar neutrino spectrum, resolving almost all spectral components originating from the proton-proton fusion chain. The presentation will review the results recently released for the second data taking phase 2012–2016 during which the detector excelled by its unprecedentedly low background levels. New results on the rate of pp, 7Be, pep and 8B neutrinos as well as their implications for solar neutrino oscillations and metallicity are discussed.
Activation of Stainless Steel 316L Anode for Anion Exchange Membrane Water Electrolysis
2023
The increased emphasis on renewable energy has resulted in a surge of R&D efforts into hydrogen and battery research. The intensive electrochemical environment surrounding the anodic oxygen evolution reaction (OER) has plagued both the activity and stability of the catalytic layer, substrate and porous transport layer, ultimately affecting both these industries. Herein, we report the benefits of potential cycling (PC) a 316L stainless steel felt porous transport layer (PTL) for use in anion exchange membrane water electrolysis. The PC increased surface roughness and created a CrFe5Ni2-OxHy layer through the oxidation of iron as shown by SEM, EDS, XPS, XRD and Raman spectroscopy. Post-PC tes…