6533b838fe1ef96bd12a3cfe
RESEARCH PRODUCT
Arthralgia as an early extraintestinal symptom of Whipple's disease. Report of five cases.
Volker KaufmannHenning E. AdamekJürgen F. RiemannMathias MaierDieter Schillingsubject
musculoskeletal diseasesMalemedicine.medical_specialtyBiopsyDiagnostico diferencialDiseasePolymerase Chain ReactionIntestinal malabsorptionDiagnosis DifferentialBiopsymedicineHumansWhipple's diseaseskin and connective tissue diseasesmedicine.diagnostic_testJoint destructionBacteriabusiness.industryWhipple DiseaseGastroenterologyvirus diseasesMiddle Agedmedicine.diseaseDermatologyArthralgiadigestive system diseasesSurgerybody regionsDifferential diagnosisbusinessWhipple Diseasedescription
Five patients with Whipple's disease all suffered from arthralgia for a long time (15 years in one case) before developing gastrointestinal or other symptoms. In all patients, arthralgia was seronegative, and there was no evidence of joint destruction. Arthralgias were symmetric and migrating. Whipple's disease is part of the differential diagnosis of enteropathic arthralgia. Thereby, the polymerase chain reaction can be a helpful tool to prove Whipple's disease in difficult differential diagnosis.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1997-01-01 | Journal of clinical gastroenterology |