Search results for "Reactive"

Can Be miR-126-3p a Biomarker of Premature Aging? An Ex Vivo and In Vitro Study in Fabry Disease

2021

Fabry disease (FD) is a lysosomal storage disorder (LSD) characterized by lysosomal accumulation of glycosphingolipids in a wide variety of cytotypes, including endothelial cells (ECs). FD patients experience a significantly reduced life expectancy compared to the general population

Chemical intervention in senescence-accelerated mice metabolism for modeling neurodegenerative diseases: an overview

2004

Abstract SAMP1 is a line of inbred mice with a pronounced misbalance between generation and neutralization of reactive oxygen species (ROS) in brain and other tissues. This results in accumulation of molecular defects in lipids, proteins and DNA moieties. The metabolic disorders appear at a very early stage of ontogenic development and induce morphological and behavioral defects manifesting from the fourth month after birth. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment of these mice induced specific changes that closely resembled parkinsonian syndrome. Neuropeptide carnosine prevented toxic effects of MPTP and protected the animals against experimental parkinsonism.

Age-associated telomere shortening in mouse oocytes

2013

Abstract Background Oocytes may undergo two types of aging. The first is induced by exposure to an aged ovarian microenvironment before being ovulated, known as ‘reproductive or maternal aging’, and the second by either a prolonged stay in the oviduct before fertilization or in vitro aging prior to insemination, known as ‘postovulatory aging’. However, the molecular mechanisms underlying these aging processes remain to be elucidated. As telomere shortening in cultured somatic cells triggers replicative senescence, telomere shortening in oocytes during reproductive and postovulatory aging may predict developmental competence. This study aimed to ascertain the mechanisms underlying altered te…

Pharmacological prevention of eNOS uncoupling.

2013

Under physiological conditions, nitric oxide (NO) is produced in the vasculature mainly by the endothelial NO synthase (eNOS). This endothelium-derived NO is a protective molecule with antihypertensive, antithrombotic and anti-atherosclerotic properties. Cardiovascular risk factors such as hypertension, hypercholesterolemia, cigarette smoking and diabetes mellitus induce oxidative stress mostly by stimulation of the NADPH oxidase. Overproduction of reactive oxygen species leads to oxidation of tetrahydrobiopterin (BH4), the essential cofactor of eNOS. In BH4 deficiency, oxygen reduction uncouples from NO synthesis, thereby converting eNOS to a superoxide- producing enzyme. Consequently, NO …

Effect of sodium dodecyl sulfate (SDS) on stress response in the Mediterranean mussel (Mytilus Galloprovincialis): Regulatory volumedecrease (Rvd) an…

2014

In this study the effects of an anionic surfactant, sodium dodecyl sulfate (SDS), are assessed on the Mediterranean mussel (. Mytilus galloprovincialis), exposed for 18 days at a concentration ranging from 0.1. mg/l to 1. mg/l. The effects are monitored using biomarkers related to stress response, such as regulatory volume decrease (RVD), and to oxidative stress, such as reactive oxygen species (ROS), endogenous antioxidant systems and Hsp70 levels. The results demonstrate that cells from the digestive gland of M. galloprovincialis, exposed to SDS were not able to perform the RVD owing to osmotic stress. Further, SDS causes oxidative stress in treated organisms, as demonstrated by the incre…

Influence of Operational Strategies for the Recovery of Magnesium Hydroxide from Brines at a Pilot Scale

2022

The continuous depletion of minerals caused by land mining and the increase in their demand have pushed the development of novel sustainable technological processes for mineral recovery from unconventional sources. In this context, magnesium (Mg) has gained considerable attention for its peculiar properties and high relevance of its compounds, such as magnesium hydroxide, Mg(OH)2. In the present work, the influence of several operating conditions on the Mg(OH)2 precipitation process was thoroughly investigated by adopting a novel multiple feed-plug flow reactor. The influence of (i) initial Mg2+ concentrations in the feed stream; (ii) brine and alkaline flow rates; and (iii) the product rec…

Reactive crystallisation process for magnesium recovery from concentrated brines

2014

Seawater brines, generated either by natural or anthropic processes, often cause significant environmental issues related to their disposal. A clear example is the case of brines from desalination plants, which can have severe environmental impacts on the receiving water body. On the other side, brines can represent a rich and appealing source of raw materials, especially when they are very concentrated, as it happens with bitterns (i.e. exhausted brines) produced in saltworks. In particular, magnesium concentration can reach values up to 30-40 kg/m3 of brine, which is 20-30 times that of typical seawater. An experimental campaign has been carried out in the present work for assessing the p…

Synthesis and characterization of magnesium compounds recovered from exhausted brines.

2023

Constrained Robust MultiObjective Optimization for Reactive Design in Distribution Systems

2006

This paper presents a new formulation including robustness of solution of constrained multiobjective design or reactive power compensation. The algorithm used for optimization is the NSGA-II (Non dominated Sorting Genetic Algorithm II) with a special crowded comparison operator for constraints handling. The need for including the issue of robustness of solutions derives from the simple observation that loads are uncertain in distribution systems and their estimation is often affected by errors. In design problems it is desirable to consider the loads with a certain range of variation. In this paper the NSGA-II algorithm is applied to efficiently solve the issue and the solutions attained co…

A Technical Approach to the Energy Blockchain in Microgrids

2018

The present paper considers some technical issues related to the “energy blockchain” paradigm applied to microgrids. In particular, what appears from the study is that the superposition of energy transactions in a microgrid creates a variation of the power losses in all the branches of the microgrid. Traditional power losses allocation in distribution systems takes into account only generators while, in this paper, a real-time attribution of power losses to each transaction involving one generator and one load node is done by defining some suitable indices. Besides, the presence of P–V nodes increases the level of reactive flows and provides a more complex technical perspective. For this re…