Search results for "Real-Time"
showing 10 items of 881 documents
Imiquimod-Induced Psoriasis in Mice Depends on the IL-17 Signaling of Keratinocytes
2018
The pathology of psoriasis strongly depends on IL-17A. Monoclonal antibodies blocking either the cytokine or its receptor are among the most efficient treatments for psoriatic patients. Keratinocytes can be activated upon exposure to IL-17A and tumor necrosis factor-α and secrete secondary cytokines and chemokines in the inflamed skin. In psoriasis and its imiquimod-induced mouse model, a strong skin infiltration of neutrophils and inflammatory monocytes can be observed. However, to date, it is not clear how exactly those cellular populations are attracted to the skin and how they contribute to the pathogenesis of the disease. To define the crucial cell type responding to IL-17 and initiati…
Exosomes released by keratinocytes modulate melanocyte pigmentation
2015
Cells secrete extracellular vesicles (EVs), exosomes and microvesicles, which transfer proteins, lipids and RNAs to regulate recipient cell functions. Skin pigmentation relies on a tight dialogue between keratinocytes and melanocytes in the epidermis. Here we report that exosomes secreted by keratinocytes enhance melanin synthesis by increasing both the expression and activity of melanosomal proteins. Furthermore, we show that the function of keratinocyte-derived exosomes is phototype-dependent and is modulated by ultraviolet B. In sum, this study uncovers an important physiological function for exosomes in human pigmentation and opens new avenues in our understanding of how pigmentation is…
Concurrent and Distributed Projection through Local Interference for Wireless Sensor Networks
2012
In this paper we use a gossip algorithm to obtain the projection of the observed signal into a subspace of lower dimension. Gossip algorithms allow distributed, fast and efficient computations on a Wireless Sensor Network and they can be properly modified to evaluate the sought projection. By combining computation coding with gossip algorithms we proposed a novel strategy that leads to important saving on convergence time as well as exponentially decreasing energy consumption, as the size of the network increases.
CiNetView - Graphic Interface for Wireless Sensor Network Deployment and Monitoring
2010
Reliable communication is crucial for successful deployment of a wireless sensor network. Many environmental factors can affect the performance of radio links, and the deployment of a network without real-time information about link qualities can be a demanding task. This paper describes the CiNetView application that is intended to support the deployment and monitoring of wireless sensor network. CiNetView is based on diagnostic information collected by sensor nodes, and it allows the user to see a graphical presentation of the network topology and to monitor the network diagnostic information in real time.
Hypothalamic CB1 cannabinoid receptors regulate energy balance in mice.
2012
Cannabinoid type 1 (CB(1)) receptor activation is generally considered a powerful orexigenic signal and inhibition of the endocannabinoid system is beneficial for the treatment of obesity and related metabolic diseases. The hypothalamus plays a critical role in regulating energy balance by modulating both food intake and energy expenditure. Although CB(1) receptor signaling has been implicated in the modulation of both these mechanisms, a complete understanding of its role in the hypothalamus is still lacking. Here we combined a genetic approach with the use of adeno-associated viral vectors to delete the CB(1) receptor gene in the adult mouse hypothalamus and assessed the impact of such ma…
The ATLAS Simulation Infrastructure
2010
52 páginas, 10 figuras, 18 tablas.-- This article is distributed under the terms of the Creative Commons Attribution Noncommercial License.-- et al. (The ATLAS Collaboration).
Development of a low-cost IoT system to detect and locate lightning strikes
2020
Lightnings are violent natural phenomena and can generate many expenditures, specially when they strike in urban areas. The identification of the concrete geographic area where they strike is of critical importance for emergency services in order to enhance their effectiveness by doing an intensive coverage of the affected area. To achieve this aim, this paper proposes a design, prototype and validation of a distributed network of Internet of Things (IoT) devices to enable detection and location of lightning strikes. The IoT devices are empowered with lightning detection capabilities and are synchronized with the other devices in the sensor network. All of them cooperate within a network th…
Connected and Autonomous Vehicles cooperate with the pedestrian in industrial sites based on trajectory optimization and vehicle signalization system
2020
Connected and autonomous vehicles (CAV) is the development trend in the field of transportation systems. Recent studies show that the resources sharing between pedestrians and CAV is a big challenge. Considering traffic safety and efficiency at that sharing point not only requires a collision avoidance system but also more communicative behaviors of the CAV. More precisely, pedestrian needs to understand the intention of the incoming CAV whether it will cross first or not according to its speed profile. This paper uses the optimal trajectory control to provide CAV with a communicative behavior. A scenario where CAV and pedestrian cooperate together to cross a conflict zone is studied. A com…
Upregulated transcription of phenoloxidase genes in the pharynx and endostyle of Ciona intestinalis in response to LPS
2015
We investigated the role of phenoloxidases (POs) in ascidians inflammatory reaction, a components of a copper-containing protein family involved in invertebrate immune system. In Ciona intestinalis two phenoloxidases (CinPO-1, CinPO-2) have been sequenced. In the present study, real time PCR analysis showed that both CinPO-1 and CinPO-2 genes were modulated by LPS inoculation suggesting that they are inducible and highly expressed in the inflamed pharynx. In situ hybridization disclosed CinPO-1 and CinPO-2 transcripts in pharynx hemocytes (granulocytes) and, mainly, in unilocular refractile granulocytes (URG) which mainly populated the inflamed tunic matrix. Interestingly, the genes are als…
Responses of retinal arterioles and ciliary arteries in pigs with acute respiratory distress syndrome (ARDS)
2019
Abstract Acute respiratory distress syndrome (ARDS) is a clinical syndrome of acute lung failure in critically sick patients, which severely compromises the function of multiple organs, including the brain. Although, the optic nerve and the retina are a part of the central nervous system, the effects of ARDS on these ocular structures are completely unknown. Thus, the major goal of this study was to test the hypothesis that ARDS affects vascular function in the eye. ARDS was induced in anesthetized pigs by intratracheal injection of lipopolysaccharide (LPS). Sham-treated animals served as controls. Pigs were monitored for 8 h and then sacrificed. Subsequently, retinal arterioles and short p…