Search results for "Recurrence"

Analysis of p53 and mdm2 proteins in malignant fibrous histiocytoma in absence of gene alteration: prognostic significance.

2000

TP53 and MDM2 genes and their protein expression were evaluated in frozen and paraffin-embedded tissue from 27 patients with malignant fibrous histiocytoma to elucidate the relationship between them, their implication in tumor progression mechanisms and their possible diagnostic-prognostic value in malignant fibrous histiocytoma. Single-strand conformation polymorphism analysis and direct sequencing of polymerase chain reaction-amplified DNA were used to establish two TP53 mutations (7.4%): a point mutation and a 63-bp duplication. Amplification of the MDM2 gene was observed in two tumors (7.4%) by means of Southern-blot analysis, one of them also carrying the TP53 point mutation. Immunohis…

Laparoscopic lymph node dissection should be performed before fertility preserving treatment of patients with cervical cancer

2012

Objective: The aim of this study is to assess our results of treatment of women with stage I cervical cancer > 2 cm in diameter seeking fertility preservation. Treatment consisted of Laparoscopic Pelvic and Paraaortic Lymphadenectomy (LPPLND), and when no nodal metastasis was detected, neoadjuvant chemotherapy (NACT) followed by radical vaginal trachelectomy (RVT). Patients with positive lymph nodes underwent primary chemoradiation. Methods: A cohort of women younger than 40 years of age with stage I disease > 2 cm who underwent LPPLND and either NACT and RVT or chemoradiation. Oncological outcome was evaluated prospectively. Results: Eighteen women were eligible for this study. Twelve (67%…

Mesh complications following prolapse surgery: management and outcome.

2011

Abstract Objective This is a description of complications following prolapse surgery with the use of alloplastic materials, the management and outcome. Study design 54 women have been referred to Mainz, urogynecology referral center due to complications following mesh-augmented prolapse surgery. Results The complaints who lead to the admission are expressed by the new terminology and standardized classification for complications arising directly from the insertion of prostheses and grafts in female pelvic floor surgery [1] . Pain (66.7%), mesh erosion (55.6%) and vaginal discharge (48.1%) were the most frequent complaints. Revision was performed after a median time of 27.2 months post mesh …

Annealed Invariance Principle for Random Walks on Random Graphs Generated by Point Processes in R-d

2016

International audience; We consider simple random walks on random graphs embedded in R-d and generated by point processes such as Delaunay triangulations, Gabriel graphs and the creek-crossing graphs. Under suitable assumptions on the point process, we show an annealed invariance principle for these random walks. These results hold for a large variety of point processes including Poisson point processes, Matern cluster and Matern hardcore processes which have respectively clustering and repulsiveness properties. The proof relies on the use the process of the environment seen from the particle. It allows to reconstruct the original process as an additive functional of a Markovian process und…

Possible strategy to prevent recurrence of actinic keratosis after treatment field-direct.

2020

Aperiodicity in finitely generated bi-ideals and bounded bi-ideals

2014

Disertācijā pētīts aperiodiskums divu vienpusēji bezgalīgu vārdu klašu – galīgi ģenerētu biideālu un ierobežotu bi-ideālu – kontekstā. Gan galīgi ģenerētus bi-ideālus, gan ierobežotus biideālus ir ērti uzdot, izmantojot bāzes virkni. Ierobežotu bi-ideālu gadījumā tiek nofiksēta galīga vārdu kopa, no kuras tiek uzģenerēta bāzes virkne. Savukārt galīgi ģenerētu bi-ideālu gadījumā bāzes virkne ir periodiska, līdz ar to var uzskatīt, ka ir dota galīga bāze. Efektīvā ģenerēšana un zināmie aperiodiskuma nosacījumi kalpo par motivāciju apskatīt galīgi ģenerētu bi-ideālu potenciālo pielietojumu kriptogrāfijā – aperiodisku gadījuma skaitļu ģenerēšanā. Savukārt, ierobežoti bi-ideāli ir galīgi ģenerēt…

Memory degradation induced by attention in recurrent neural architectures

2022

This paper studies the memory mechanisms in recurrent neural architectures when attention models are included. Pure-attention models like Transformers are more and more popular as they tend to outperform models with recurrent connections in many different tasks. Our conjecture is that attention prevents the recurrent connections from transferring information properly between consecutive next steps. This conjecture is empirically tested using five different models, namely, a model without attention, a standard Loung attention model, a standard Bahdanau attention model, and our proposal to add attention to the inputs in order to fill the gap between recurrent and parallel architectures (for b…

Relapse risk after autologous transplantation in patients with newly diagnosed myeloma is not related with infused tumor cell load and the outcome is…

2006

BACKGROUND AND OBJECTIVES: This European Group for Blood and Marrow Transplantation (EBMT) multicentre randomized phase III study was designed to assess the safety and efficacy of CD34+ selection in newly diagnosed myeloma patients undergoing autologous transplantation. DESIGN AND METHODS: One hundred and eleven patients responsive to initial chemotherapy were randomized to receive CD34+ selected (arm A) or unselected PBPC (arm B) after conditioning with high-dose melphalan and TBI. ASO-PCR was used to assess purging efficacy and reinfused tumor load. Tumor load could be assessed in 59 patients. RESULTS: CD34+ selection gave a median tumor cell depletion of 2.2 logs (0.77-5.96). No tumor ce…

Battered Women: Victims or Survivors?

2011

AbstractFrom 1970, research into women’s responses to marital violence became much more intense than ever before. Academic literature emphasizes two explanatory perspectives: of the woman as passive victim and of the woman who uses strategies to protect herself. The main goals of this study were to explore the effectiveness of personal strategies that women use to survive violence, the factors that influence the recurrence of violence, and the demand for shelter and the role of shelters in the process of recovery and healing. We interviewed eight battered women, from rural areas, all of whom had taken refuge in shelters, some of them several time. We identified a number of psychopathologica…

SMOKING STATUS, RECURRENCE RISK AND INTRAVESICAL CHEMOTHERAPY IN NONMUSCLE- INVASIVE BLADDER CANCER

2011

Background and Aim: The influence of smoking status on the diagnosis of carcinoma of the bladder, on recurrence risk Abstracts of the 21st Annual Meeting of the Italian Society of Uro-Oncology (SIUrO), 22-24 June, 2011, Naples, Italy and response to intravesical treatment has been scarcely studied. Available studies suggest a reduction in recurrence risk with cessation of smoking, however, most studies lack sufficient statistical power. The aim of the present analysis was to study the recurrence risk and the response to intravesical chemotherapy in terms of recurrence-free rate (RFR) and recurrence-free survival (RFS) in relation to smoking status at diagnosis in patients affected by interm…