Search results for "Recurrent"
showing 10 items of 256 documents
Endometrial Receptivity Analysis (ERA): data versus opinions
2021
Abstract This article summarises and contextualises the accumulated basic and clinical data on the ERA test and addresses specific comments and opinions presented by the opponent as part of an invited debate. Progress in medicine depends on new technologies and concepts that translate to practice to solve long-standing problems. In a key example, combining RNA sequencing data (transcriptomics) with artificial intelligence (AI) led to a clinical revolution in personalising disease diagnosis and fostered the concept of precision medicine. The reproductive field is no exception. Translation of endometrial transcriptomics to the clinic yielded an objective definition of the limited time period …
PSA and PSA Kinetics Thresholds for the Presence of 68Ga-PSMA-11 PET/CT-Detectable Lesions in Patients with Biochemical Recurrent Prostate Cancer
2020
68Ga-PSMA-11 positron-emission tomography/computed tomography (PET/CT) is commonly used for restaging recurrent prostate cancer (PC) in European clinical practice. The goal of this study is to determine the optimum time for performing these PET/CT scans in a large cohort of patients by identifying the prostate-specific-antigen (PSA) and PSA kinetics thresholds for detecting and localizing recurrent PC. This retrospective analysis includes 581 patients with biochemical recurrence (BC) by definition. The performance of 68Ga-PSMA-11 PET/CT in relation to the PSA value at the scan time as well as PSA kinetics was assessed by the receiver-operating-characteristic-curve (ROC) generated by plottin…
IL-1 BLOCKADE IN PAEDIATRIC RECURRENT PERICARDITIS: A MULTICENTRIC RETROSPECTIVE STUDY OF THE ITALIAN COHORT
2019
Introduction: Acute pericarditis is an inflammatory condition causing the occurrence of pericardial effusion. In a third of patients, the disease is recurrent. First line treatment of idiopathic pericarditis consists in non-steroidal anti-inflammatory drugs (NSAIDs) and colchicine; glucocorticoids represent the second line treatment in resistant or intolerant cases. A recent clinical trial has enlightened the effectiveness of anakinra in adults and paediatric patients with colchicine-resistant recurrent pericarditis. Objectives: To describe the clinical characteristics and response to treatment in a cohort of paediatric patients with recurrent pericarditis treated with IL inhibitors. Method…
Letter to the Editor regarding the paper by Aurilio et al., A meta-analysis of oestrogen receptor, progesterone receptor and human epidermal growth f…
2014
Sir,We have read with great interest the article in press ofAurilio et al., A meta-analysis of oestrogen receptor, pro-gesterone receptor and human epidermal growth factorreceptor 2 discordance between primary breast cancerand metastases (http://dx.doi.org/10.1016/j.ejca.2003.10.004), which will appear in Eur J Cancer. In the paper,the Authors have performed a meta-analysis of the stud-ies published in the literature concerning the discor-dance rate in oestrogen receptor (ER), progesteronereceptor (PgR) and HER2 status between primarytumour and corresponding relapse. It is well known thata considerable controversy concerns the issue of hor-mone receptors (HRs) expression as well as HER2 sta…
Forecasting Aquaponic Systems Behaviour With Recurrent Neural Networks Models
2022
Aquaponic systems provide a reliable solution to grow vegetables while cultivating fish (or other aquatic organisms) in a controlled environment. The main advantage of these systems compared with traditional soil-based agriculture and aquaculture installations is the ability to produce fish and vegetables with low water consumption. Aquaponics requires a robust control system capable of optimizing fish and plant growth while ensuring a safe operation. To support the control system, this work explores the design process of Deep Learning models based on Recurrent Neural Networks to forecast one hour of pH values in small-scale industrial Aquaponics. This implementation guides us through the m…
Dynamic instability in absence of dominated splittings.
2006
We want to understand the dynamics in absence of dominated splittings. A dominated splitting is a weak form of hyperbolicity where the tangent bundle splits into invariant subbundles, each of them is more contracted or less expanded by the dynamics than the next one. We first answer an old question from Hirsch, Pugh and Shub, and show the existence of adapted metrics for dominated splittings.Mañé found on surfaces a $C^1$-generic dichotomy between hyperbolicity and Newhouse phenomenons (infinitely many sinks/sources). For that purpose, he showed that without a strong enough dominated splitting along one periodic orbit, a $C^1$-perturbation creates a sink or a source. We generalise that last…
Comparative study of molecular processes and factors affecting endometrial function in subfertile patients with uterine disorders
2021
El endometrio humano es un tejido dinámico y complejo que solo es receptivo al embrión durante un corto periodo de tiempo. Por lo tanto, la identificación de trastornos y factores que impidan que el endometrio adquiera un fenotipo receptivo es crucial para poder prevenir fallos de implantación embrionaria y aumentar las tasas de embarazo. Los trastornos uterinos son complejos, multifactoriales y poligénicos y a menudo comprometen la fertilidad femenina, aunque se desconoce con exactitud cómo afectan a la adquisición de la receptividad endometrial. Además, estos trastornos carecen actualmente de un tratamiento efectivo, a menudo presentan comorbilidad entre ellos y su incidencia aumenta con …
Brief depression among patients in general practice
1994
Depression with substantial psychosocial impairment, but not qualifying as depressive disorder according to the standard diagnostic manuals, is frequent among primary care patients. Recurrent brief depression (RBD) is a diagnostic category intended to identify a major proportion of this group of patients. The WHO study on "Psychological Problems in Primary Health Care" was used as a vehicle to estimate the proportion of patients with this diagnosis and to evaluate the validity of this diagnosis as well as of alternative concepts of brief depression with multiple episodes. This study applies a two-stage sampling scheme; 300 patients also underwent an additional interview tailored for variant…
Sorafenib in advanced hepatocellular carcinoma
2008
none 25 BACKGROUND: No effective systemic therapy exists for patients with advanced hepatocellular carcinoma. A preliminary study suggested that sorafenib, an oral multikinase inhibitor of the vascular endothelial growth factor receptor, the platelet-derived growth factor receptor, and Raf may be effective in hepatocellular carcinoma. METHODS: In this multicenter, phase 3, double-blind, placebo-controlled trial, we randomly assigned 602 patients with advanced hepatocellular carcinoma who had not received previous systemic treatment to receive either sorafenib (at a dose of 400 mg twice daily) or placebo. Primary outcomes were overall survival and the time to symptomatic progression. Seconda…
Recurrent Meningitis Associated With Duane Syndrome Type 1
2012
We present the case of a 17-month-old male patient with a bilateral Duane syndrome type 1 associated to unilateral cochleovestibular dysplasia, perilymphatic fistula and recurrent meningitis. Diagnosis was carried out by MRI and CT scan. His management and treatment are described, as well as the postoperative evolution. We believe this is an exceptional case due to the low frequency of this syndrome, as well as to the otoneurological complications.